PMC:7601109 / 47224-51462
Annnotations
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T73 | 3620-3625 | Body_part | denotes | larva | http://purl.obolibrary.org/obo/UBERON_0002548 |
| T74 | 3656-3660 | Body_part | denotes | milk | http://purl.obolibrary.org/obo/UBERON_0001913 |
| T75 | 3759-3772 | Body_part | denotes | gastrocnemius | http://purl.obolibrary.org/obo/UBERON_0001388 |
| T76 | 3814-3818 | Body_part | denotes | milk | http://purl.obolibrary.org/obo/UBERON_0001913 |
| T77 | 3823-3827 | Body_part | denotes | milk | http://purl.obolibrary.org/obo/UBERON_0001913 |
| T78 | 4014-4018 | Body_part | denotes | milk | http://purl.obolibrary.org/obo/UBERON_0001913 |
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T336 | 20-26 | Body_part | denotes | Muscle | http://purl.org/sig/ont/fma/fma32558 |
| T337 | 27-34 | Body_part | denotes | Protein | http://purl.org/sig/ont/fma/fma67257 |
| T338 | 63-69 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T339 | 70-77 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T340 | 127-134 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T341 | 217-223 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T342 | 279-287 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T343 | 320-326 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T344 | 348-370 | Body_part | denotes | transmembrane proteins | http://purl.org/sig/ont/fma/fma67858 |
| T345 | 481-489 | Body_part | denotes | myoblast | http://purl.org/sig/ont/fma/fma70335 |
| T346 | 569-584 | Body_part | denotes | plasma membrane | http://purl.org/sig/ont/fma/fma63841 |
| T347 | 588-597 | Body_part | denotes | myoblasts | http://purl.org/sig/ont/fma/fma70335 |
| T348 | 659-667 | Body_part | denotes | cysteine | http://purl.org/sig/ont/fma/fma82751 |
| T349 | 692-699 | Body_part | denotes | leucine | http://purl.org/sig/ont/fma/fma82757 |
| T350 | 706-716 | Body_part | denotes | Amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T351 | 736-743 | Body_part | denotes | leucine | http://purl.org/sig/ont/fma/fma82757 |
| T352 | 775-781 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T353 | 782-789 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T354 | 877-884 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T355 | 917-925 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T356 | 940-946 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T357 | 1084-1090 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T358 | 1091-1098 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T359 | 1226-1237 | Body_part | denotes | fatty acids | http://purl.org/sig/ont/fma/fma82738 |
| T360 | 1354-1360 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T361 | 1414-1425 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T362 | 1438-1444 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T363 | 1548-1558 | Body_part | denotes | amino acid | http://purl.org/sig/ont/fma/fma82739 |
| T364 | 1650-1656 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T365 | 1719-1730 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T366 | 1743-1749 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T367 | 1825-1832 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T368 | 1866-1873 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T369 | 1905-1916 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T370 | 1998-2005 | Body_part | denotes | insulin | http://purl.org/sig/ont/fma/fma83365 |
| T371 | 2087-2098 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T372 | 2174-2185 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T373 | 2318-2329 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T374 | 2392-2398 | Body_part | denotes | valine | http://purl.org/sig/ont/fma/fma82766 |
| T375 | 2438-2449 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T376 | 2617-2624 | Body_part | denotes | cytosol | http://purl.org/sig/ont/fma/fma66836 |
| T377 | 2643-2652 | Body_part | denotes | lysosomes | http://purl.org/sig/ont/fma/fma63836 |
| T378 | 2750-2756 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T379 | 2798-2807 | Body_part | denotes | ribosomal | http://purl.org/sig/ont/fma/fma66867 |
| T380 | 2808-2816 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T381 | 2882-2889 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T382 | 3004-3010 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T383 | 3183-3189 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T384 | 3190-3197 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T385 | 3221-3227 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T386 | 3322-3329 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T387 | 3449-3455 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T388 | 3490-3496 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T389 | 3586-3592 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T390 | 3593-3600 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T391 | 3656-3660 | Body_part | denotes | milk | http://purl.org/sig/ont/fma/fma62100 |
| T392 | 3759-3779 | Body_part | denotes | gastrocnemius muscle | http://purl.org/sig/ont/fma/fma22541 |
| T393 | 3814-3818 | Body_part | denotes | milk | http://purl.org/sig/ont/fma/fma62100 |
| T394 | 3823-3827 | Body_part | denotes | milk | http://purl.org/sig/ont/fma/fma62100 |
| T395 | 3893-3899 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T396 | 3989-4000 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
| T397 | 4014-4018 | Body_part | denotes | milk | http://purl.org/sig/ont/fma/fma62100 |
| T398 | 4031-4037 | Body_part | denotes | muscle | http://purl.org/sig/ont/fma/fma32558 |
| T399 | 4193-4201 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T400 | 4206-4217 | Body_part | denotes | amino acids | http://purl.org/sig/ont/fma/fma82739 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T95 | 973-983 | Disease | denotes | sarcopenia | http://purl.obolibrary.org/obo/MONDO_0006516 |
| T96 | 1354-1368 | Disease | denotes | muscle wasting | http://purl.obolibrary.org/obo/MONDO_0004323 |
| T97 | 3386-3398 | Disease | denotes | malnourished | http://purl.obolibrary.org/obo/MONDO_0006873 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T669 | 20-26 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | Muscle |
| T670 | 20-26 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | Muscle |
| T671 | 20-26 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | Muscle |
| T672 | 20-26 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | Muscle |
| T673 | 63-69 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T674 | 63-69 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T675 | 63-69 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T676 | 63-69 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T677 | 172-180 | http://purl.obolibrary.org/obo/UBERON_0005409 | denotes | GI tract |
| T678 | 208-223 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T679 | 208-223 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T680 | 208-223 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T681 | 320-326 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T682 | 320-326 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T683 | 320-326 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T684 | 320-326 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T685 | 381-389 | http://purl.obolibrary.org/obo/PR_000018263 | denotes | peptides |
| T686 | 501-502 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T687 | 569-575 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T688 | 576-584 | http://purl.obolibrary.org/obo/UBERON_0000158 | denotes | membrane |
| T689 | 745-746 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T690 | 775-781 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T691 | 775-781 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T692 | 775-781 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T693 | 775-781 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T694 | 940-946 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T695 | 940-946 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T696 | 940-946 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T697 | 940-946 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T698 | 1084-1090 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T699 | 1084-1090 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T700 | 1084-1090 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T701 | 1084-1090 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T702 | 1345-1360 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T703 | 1345-1360 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T704 | 1345-1360 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T705 | 1429-1444 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T706 | 1429-1444 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T707 | 1429-1444 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T708 | 1474-1482 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T709 | 1498-1508 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activating |
| T710 | 1641-1656 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T711 | 1641-1656 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T712 | 1641-1656 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T713 | 1734-1749 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T714 | 1734-1749 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T715 | 1734-1749 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T716 | 1806-1807 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T717 | 1846-1847 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T718 | 1998-2005 | http://purl.obolibrary.org/obo/PR_000009054 | denotes | insulin |
| T719 | 2035-2044 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T720 | 2146-2154 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T721 | 2214-2222 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activate |
| T722 | 2267-2272 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T723 | 2476-2486 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T724 | 2643-2652 | http://purl.obolibrary.org/obo/GO_0005764 | denotes | lysosomes |
| T725 | 2741-2756 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T726 | 2741-2756 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T727 | 2741-2756 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T728 | 2764-2774 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T729 | 2837-2847 | http://purl.obolibrary.org/obo/NCBITaxon_2759 | denotes | eukaryotic |
| T730 | 2914-2919 | http://purl.obolibrary.org/obo/CLO_0053406 | denotes | 4eBP1 |
| T731 | 3004-3010 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T732 | 3004-3010 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T733 | 3004-3010 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T734 | 3004-3010 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T735 | 3183-3189 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T736 | 3183-3189 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T737 | 3183-3189 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T738 | 3183-3189 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T739 | 3221-3227 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T740 | 3221-3227 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T741 | 3221-3227 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T742 | 3221-3227 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T743 | 3354-3359 | http://purl.obolibrary.org/obo/CLO_0053406 | denotes | 4eBP1 |
| T744 | 3409-3411 | http://purl.obolibrary.org/obo/CLO_0001313 | denotes | 36 |
| T745 | 3449-3455 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T746 | 3449-3455 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T747 | 3449-3455 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T748 | 3449-3455 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T749 | 3490-3496 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T750 | 3490-3496 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T751 | 3490-3496 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T752 | 3490-3496 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T753 | 3586-3592 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T754 | 3586-3592 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T755 | 3586-3592 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T756 | 3586-3592 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T757 | 3620-3625 | http://purl.obolibrary.org/obo/UBERON_0002548 | denotes | larva |
| T758 | 3773-3779 | http://purl.obolibrary.org/obo/UBERON_0001630 | denotes | muscle |
| T759 | 3773-3779 | http://purl.obolibrary.org/obo/UBERON_0005090 | denotes | muscle |
| T760 | 3773-3779 | http://www.ebi.ac.uk/efo/EFO_0000801 | denotes | muscle |
| T761 | 3773-3779 | http://www.ebi.ac.uk/efo/EFO_0001949 | denotes | muscle |
| T762 | 3884-3899 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T763 | 3884-3899 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T764 | 3884-3899 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
| T765 | 4022-4037 | http://purl.obolibrary.org/obo/UBERON_0001134 | denotes | skeletal muscle |
| T766 | 4022-4037 | http://purl.obolibrary.org/obo/UBERON_0014892 | denotes | skeletal muscle |
| T767 | 4022-4037 | http://www.ebi.ac.uk/efo/EFO_0000888 | denotes | skeletal muscle |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T709 | 27-34 | Chemical | denotes | Protein | http://purl.obolibrary.org/obo/CHEBI_16541 |
| T710 | 70-77 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T711 | 127-134 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T712 | 172-174 | Chemical | denotes | GI | http://purl.obolibrary.org/obo/CHEBI_73907 |
| T713 | 279-287 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T714 | 362-370 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T715 | 381-389 | Chemical | denotes | peptides | http://purl.obolibrary.org/obo/CHEBI_16670 |
| T716 | 659-667 | Chemical | denotes | cysteine | http://purl.obolibrary.org/obo/CHEBI_15356 |
| T717 | 692-699 | Chemical | denotes | leucine | http://purl.obolibrary.org/obo/CHEBI_25017 |
| T718 | 706-716 | Chemical | denotes | Amino acid | http://purl.obolibrary.org/obo/CHEBI_33704 |
| T719 | 712-716 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T720 | 736-743 | Chemical | denotes | leucine | http://purl.obolibrary.org/obo/CHEBI_25017 |
| T721 | 782-789 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T722 | 808-818 | Chemical | denotes | metabolite | http://purl.obolibrary.org/obo/CHEBI_25212 |
| T723 | 821-828 | Chemical | denotes | hydroxy | http://purl.obolibrary.org/obo/CHEBI_43176 |
| T724 | 877-884 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T725 | 917-925 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T726 | 1091-1098 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T727 | 1190-1199 | Chemical | denotes | nutrients | http://purl.obolibrary.org/obo/CHEBI_33284 |
| T728 | 1205-1214 | Chemical | denotes | vitamin D | http://purl.obolibrary.org/obo/CHEBI_27300 |
| T729 | 1205-1212 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T730 | 1226-1237 | Chemical | denotes | fatty acids | http://purl.obolibrary.org/obo/CHEBI_35366 |
| T731 | 1232-1237 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T28371 | 1414-1425 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T5751 | 1414-1419 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T11752 | 1420-1425 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T4 | 1548-1558 | Chemical | denotes | amino acid | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T45057 | 1548-1553 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T61372 | 1554-1558 | Chemical | denotes | acid | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T55344 | 1719-1730 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T27259 | 1719-1724 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T13669 | 1725-1730 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T64550 | 1808-1816 | Chemical | denotes | nutrient | http://purl.obolibrary.org/obo/CHEBI_33284 |
| T23687 | 1825-1832 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T46508 | 1866-1873 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T21569 | 1905-1916 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T62121 | 1905-1910 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T73912 | 1911-1916 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T74297 | 1933-1936 | Chemical | denotes | ATP | http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616 |
| T27922 | 1998-2005 | Chemical | denotes | insulin | http://purl.obolibrary.org/obo/CHEBI_145810 |
| T59193 | 2087-2098 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T94290 | 2087-2092 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T58757 | 2093-2098 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T30204 | 2174-2185 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T8531 | 2174-2179 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T19387 | 2180-2185 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T6863 | 2318-2329 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T39885 | 2318-2323 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T30308 | 2324-2329 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T76570 | 2357-2368 | Chemical | denotes | royal jelly | http://purl.obolibrary.org/obo/CHEBI_78665 |
| T62196 | 2392-2398 | Chemical | denotes | valine | http://purl.obolibrary.org/obo/CHEBI_27266 |
| T30 | 2438-2449 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T25391 | 2438-2443 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T36795 | 2444-2449 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T93939 | 2506-2518 | Chemical | denotes | nitric oxide | http://purl.obolibrary.org/obo/CHEBI_16480 |
| T31798 | 2513-2518 | Chemical | denotes | oxide | http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356 |
| T98156 | 2808-2816 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T92500 | 2882-2889 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T32115 | 2957-2968 | Chemical | denotes | royal jelly | http://purl.obolibrary.org/obo/CHEBI_78665 |
| T78412 | 2976-2979 | Chemical | denotes | HDA | http://purl.obolibrary.org/obo/CHEBI_17314 |
| T92634 | 3190-3197 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T24247 | 3322-3329 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T65848 | 3537-3548 | Chemical | denotes | royal jelly | http://purl.obolibrary.org/obo/CHEBI_78665 |
| T50086 | 3593-3600 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T15920 | 3685-3689 | Chemical | denotes | PUFA | http://purl.obolibrary.org/obo/CHEBI_26208|http://purl.obolibrary.org/obo/CHEBI_76567 |
| T4802 | 3694-3705 | Chemical | denotes | polyphenols | http://purl.obolibrary.org/obo/CHEBI_26195 |
| T1628 | 3842-3846 | Chemical | denotes | PUFA | http://purl.obolibrary.org/obo/CHEBI_26208|http://purl.obolibrary.org/obo/CHEBI_76567 |
| T89207 | 3989-4000 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T56473 | 3989-3994 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T78828 | 3995-4000 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
| T65208 | 4124-4135 | Chemical | denotes | royal jelly | http://purl.obolibrary.org/obo/CHEBI_78665 |
| T51740 | 4193-4201 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T73091 | 4206-4217 | Chemical | denotes | amino acids | http://purl.obolibrary.org/obo/CHEBI_33709 |
| T27119 | 4206-4211 | Chemical | denotes | amino | http://purl.obolibrary.org/obo/CHEBI_46882 |
| T34014 | 4212-4217 | Chemical | denotes | acids | http://purl.obolibrary.org/obo/CHEBI_37527 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T197 | 27-44 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | Protein Synthesis |
| T198 | 35-44 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | Synthesis |
| T199 | 70-87 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein synthesis |
| T200 | 78-87 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T201 | 92-103 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
| T202 | 445-454 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T203 | 481-496 | http://purl.obolibrary.org/obo/GO_0007520 | denotes | myoblast fusion |
| T204 | 539-551 | http://purl.obolibrary.org/obo/GO_0051179 | denotes | localization |
| T205 | 1509-1529 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factor |
| T206 | 1509-1522 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T207 | 1808-1824 | http://purl.obolibrary.org/obo/GO_0009594 | denotes | nutrient sensing |
| T208 | 1853-1884 | http://purl.obolibrary.org/obo/GO_0051246 | denotes | regulator of protein metabolism |
| T209 | 1866-1884 | http://purl.obolibrary.org/obo/GO_0019538 | denotes | protein metabolism |
| T210 | 1874-1884 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
| T211 | 1976-1982 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T212 | 2035-2044 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T213 | 2116-2122 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
| T214 | 2848-2870 | http://purl.obolibrary.org/obo/GO_0006413 | denotes | translation initiation |
| T215 | 2848-2859 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | translation |
| T216 | 3190-3207 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein synthesis |
| T217 | 3198-3207 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T218 | 3322-3341 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein translation |
| T219 | 4053-4059 | http://purl.obolibrary.org/obo/GO_0040007 | denotes | growth |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T46 | 1113-1133 | Phenotype | denotes | immune dysregulation | http://purl.obolibrary.org/obo/HP_0002958 |
| T47 | 1354-1368 | Phenotype | denotes | muscle wasting | http://purl.obolibrary.org/obo/HP_0003202 |
| T48 | 1953-1969 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T286 | 0-4 | Sentence | denotes | 4.4. |
| T287 | 5-44 | Sentence | denotes | Enhancement of Muscle Protein Synthesis |
| T288 | 45-337 | Sentence | denotes | Imbalance between muscle protein synthesis and degradation is associated with low protein intake and altered efficiency of the GI tract in old age, which triggers skeletal muscle loss and poor physical performance [36,40], given that proteins are the main building blocks of muscle myofibers. |
| T289 | 338-705 | Sentence | denotes | Moreover, transmembrane proteins and micro-peptides (e.g., myomixer and myomaker/Tmem8c) contribute to the formation of myofibers by promoting myoblast fusion via a mechanism that involves appropriate localization of Tmem8c at the plasma membrane of myoblasts allowing trafficking related to palmitoylation of C-terminal cysteine residues and C-terminal leucine [17]. |
| T290 | 706-1308 | Sentence | denotes | Amino acid supplements (e.g., leucine, a master dietary regulator of muscle protein turnover, and its metabolite β-hydroxy β-methylbutyrate) and early refeeding with high protein diet (especially fast digestive proteins) can preserve muscle mass and function, revert sarcopenia, and enhance mobility and quality of life (QoL) by correcting age-related nutritional deficiencies, muscle protein turnover, and immune dysregulation—these effects are even greater when combined with other nutrients like vitamin D or omega 3 fatty acids as well as with physical exercise [6,131,132,133,134,135,136,137,138]. |
| T291 | 1309-1576 | Sentence | denotes | Research indicates that age-related skeletal muscle wasting results mainly from insufficient delivery of amino acids to skeletal muscle due to dysregulations in the activity of mTORC1- and activating transcription factor-4 (ATF4)-mediated amino acid sensing pathways. |
| T292 | 1577-1885 | Sentence | denotes | Meanwhile, interventions that ameliorate age-related damages in skeletal muscle operate primarily by reversing alterations in the delivery of amino acids to skeletal muscle via upregulation of mTORC1 and/or ATF4 [139]. mTORC1 is a nutrient sensing protein that acts as a core regulator of protein metabolism. |
| T293 | 1886-2053 | Sentence | denotes | It is sensitive to amino acids, energy status (ATP), stress (e.g., oxidative stress), and growth factors (e.g., insulin), which all can regulate its signaling [2,136]. |
| T294 | 2054-2162 | Sentence | denotes | Nevertheless, bioavailability of amino acids is necessary for growth factors to effectively activate mTORC1. |
| T295 | 2163-2236 | Sentence | denotes | Even more, amino acids on their own can adequately activate mTORC1 [136]. |
| T296 | 2237-2583 | Sentence | denotes | Evidence from preclinical and human studies confirms that ingestion of essential amino acids (similar to those found in royal jelly and bee pollen such as valine) increases cellular bioavailability of amino acids, which is associated with activation of the endothelial nitric oxide synthase (eNOs) pathway. eNOs further upregulates mTORC1 kinase. |
| T297 | 2584-2935 | Sentence | denotes | Translocation of mTORC1 from the cytosol to the surface of lysosomes is associated with improved mitochondrial biogenesis and cellular oxidative capacity in skeletal muscle due to activation of its substrates: P70 ribosomal proteins S6 kinase (S6K) and eukaryotic translation initiation 4E-binding protein 1 (eIF4E, also known as 4eBP1) [120,135,136]. |
| T298 | 2936-3083 | Sentence | denotes | As shown in Table 1, royal jelly and 10-HDA significantly increased muscle mass [54,96,100] and improved motor performance in aged rats [95,98,99]. |
| T299 | 3084-3413 | Sentence | denotes | In addition, dietary supplementation with monofloral bee pollen significantly improved the rate of muscle protein synthesis and restored muscle mass in emaciated old rats via upregulation of mTOR and two related downstream controllers of protein translation: p70S6k and 4eBP1, which were suppressed in malnourished old rats [36]. |
| T300 | 3414-3564 | Sentence | denotes | Although propolis improved various muscle-related parameters, its effect on muscle mass in rodents was limited—relative to royal jelly and bee pollen. |
| T301 | 3565-3645 | Sentence | denotes | However, it fostered muscle protein deposition in post-larva Nile tilapia [104]. |
| T302 | 3646-3906 | Sentence | denotes | Moreover, milk naturally enriched with PUFA and polyphenols from propolis remarkably increased the weight of the gastrocnemius muscle of growing obese rats while whole milk and milk enriched with PUFA only could not express any effect on skeletal muscle [105]. |
| T303 | 3907-4060 | Sentence | denotes | Therefore, this finding denotes that propolis could have enhanced the delivery of amino acids available in milk to skeletal muscle leading to its growth. |
| T304 | 4061-4238 | Sentence | denotes | Altogether, it is likely that the observed anabolic effects of royal jelly and bee pollen are associated with their high content of proteins and amino acids [32,36,83,84,85,86]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1135 | 419-425 | Gene | denotes | Tmem8c | Gene:296601 |
| 1136 | 555-561 | Gene | denotes | Tmem8c | Gene:296601 |
| 1137 | 1046-1049 | Gene | denotes | age | Gene:81759 |
| 1138 | 188-191 | Gene | denotes | age | Gene:81759 |
| 1139 | 659-667 | Chemical | denotes | cysteine | MESH:D003545 |
| 1140 | 692-699 | Chemical | denotes | leucine | MESH:D007930 |
| 1141 | 736-743 | Chemical | denotes | leucine | MESH:D007930 |
| 1142 | 819-845 | Chemical | denotes | β-hydroxy β-methylbutyrate | MESH:C004961 |
| 1143 | 1205-1214 | Chemical | denotes | vitamin D | MESH:D014807 |
| 1144 | 1218-1237 | Chemical | denotes | omega 3 fatty acids | MESH:D015525 |
| 1145 | 208-228 | Disease | denotes | skeletal muscle loss | MESH:D005207 |
| 1146 | 775-798 | Disease | denotes | muscle protein turnover | MESH:D063806 |
| 1147 | 973-983 | Disease | denotes | sarcopenia | MESH:D055948 |
| 1148 | 1058-1082 | Disease | denotes | nutritional deficiencies | MESH:D044342 |
| 1149 | 1084-1107 | Disease | denotes | muscle protein turnover | MESH:D063806 |
| 1174 | 1486-1492 | Gene | denotes | mTORC1 | Gene:382056 |
| 1175 | 1498-1531 | Gene | denotes | activating transcription factor-4 | Gene:79255 |
| 1176 | 1533-1537 | Gene | denotes | ATF4 | Gene:79255 |
| 1177 | 1770-1776 | Gene | denotes | mTORC1 | Gene:382056 |
| 1178 | 1784-1788 | Gene | denotes | ATF4 | Gene:79255 |
| 1179 | 1796-1802 | Gene | denotes | mTORC1 | Gene:382056 |
| 1180 | 1998-2005 | Gene | denotes | insulin | Gene:3630 |
| 1181 | 2155-2161 | Gene | denotes | mTORC1 | Gene:382056 |
| 1182 | 2223-2229 | Gene | denotes | mTORC1 | Gene:382056 |
| 1183 | 2494-2527 | Gene | denotes | endothelial nitric oxide synthase | Gene:4846 |
| 1184 | 2529-2533 | Gene | denotes | eNOs | Gene:4846 |
| 1185 | 2569-2575 | Gene | denotes | mTORC1 | Gene:382056 |
| 1186 | 2601-2607 | Gene | denotes | mTORC1 | Gene:382056 |
| 1187 | 2817-2826 | Gene | denotes | S6 kinase | Gene:83840 |
| 1188 | 2828-2831 | Gene | denotes | S6K | Gene:83840 |
| 1189 | 2893-2898 | Gene | denotes | eIF4E | Gene:117045 |
| 1190 | 2914-2919 | Gene | denotes | 4eBP1 | Gene:116636 |
| 1191 | 2544-2548 | Gene | denotes | eNOs | Gene:4846 |
| 1192 | 1618-1621 | Gene | denotes | age | Gene:81759 |
| 1193 | 1333-1336 | Gene | denotes | age | Gene:81759 |
| 1194 | 2267-2272 | Species | denotes | human | Tax:9606 |
| 1195 | 2308-2329 | Chemical | denotes | essential amino acids | MESH:D000601 |
| 1196 | 2392-2398 | Chemical | denotes | valine | MESH:D014633 |
| 1197 | 1354-1368 | Disease | denotes | muscle wasting | MESH:D009133 |
| 1208 | 3275-3279 | Gene | denotes | mTOR | Gene:56718 |
| 1209 | 3343-3349 | Gene | denotes | p70S6k | Gene:83840 |
| 1210 | 3354-3359 | Gene | denotes | 4eBP1 | Gene:116636 |
| 1211 | 3067-3071 | Species | denotes | rats | Tax:10116 |
| 1212 | 3250-3254 | Species | denotes | rats | Tax:10116 |
| 1213 | 3403-3407 | Species | denotes | rats | Tax:10116 |
| 1214 | 3626-3638 | Species | denotes | Nile tilapia | Tax:8128 |
| 1215 | 3797-3801 | Species | denotes | rats | Tax:10116 |
| 1216 | 3694-3705 | Chemical | denotes | polyphenols | MESH:D059808 |
| 1217 | 3791-3796 | Disease | denotes | obese | MESH:D009765 |