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PMC:7601109 / 4650-6142 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T97716 715-722 Body_part denotes hormone http://purl.org/sig/ont/fma/fma12278
T78890 912-919 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18548 1133-1138 Body_part denotes teeth http://purl.org/sig/ont/fma/fma314001
T75563 1219-1225 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T29941 1254-1261 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T5314 1477-1483 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T27 146-156 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T28 396-404 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T29 864-874 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T30 1385-1395 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T38921 171-172 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T82771 406-408 http://purl.obolibrary.org/obo/CLO_0050510 denotes 18
T7480 411-412 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T18967 462-468 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T49570 629-634 http://purl.obolibrary.org/obo/CLO_0001195 denotes 2 [19
T85988 1003-1011 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T56401 1074-1084 http://purl.obolibrary.org/obo/UBERON_0005409 denotes (GI) tract
T13108 1219-1225 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T28523 1219-1225 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T6036 1219-1225 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T62249 1219-1225 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T59129 1468-1483 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T93231 1468-1483 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T55365 1468-1483 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T15 694-706 Chemical denotes testosterone http://purl.obolibrary.org/obo/CHEBI_17347
T16 708-722 Chemical denotes growth hormone http://purl.obolibrary.org/obo/CHEBI_37845
T17 715-722 Chemical denotes hormone http://purl.obolibrary.org/obo/CHEBI_24621
T18 737-745 Chemical denotes steroids http://purl.obolibrary.org/obo/CHEBI_35341
T19 912-919 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T20 1075-1077 Chemical denotes GI http://purl.obolibrary.org/obo/CHEBI_73907
T21 1254-1261 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T22 1280-1285 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T76041 708-714 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T45761 1140-1145 http://purl.obolibrary.org/obo/GO_0050909 denotes taste
T38870 1454-1459 http://purl.obolibrary.org/obo/GO_0007568 denotes aging

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T9 303-308 Phenotype denotes falls http://purl.obolibrary.org/obo/HP_0002527
T10 1125-1138 Phenotype denotes loss of teeth http://purl.obolibrary.org/obo/HP_0006480

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T29 0-202 Sentence denotes Given its high prevalence in the general population, which ranges between 5 and 40% in western countries and increases up to 50% in advanced age, sarcopenia is considered a public health problem [4,15].
T30 203-410 Sentence denotes It causes progressive decline of functional capacity, contributes to frailty, increases the risk of falls and hospitalization in old people [16,17], and leads to poor outcomes in patients with COVID-19 [18].
T31 411-592 Sentence denotes A large number of pharmacological agents are being tested as anti-sarcopenic agents such as bimagrumab (BYM338), enobasarm (GTx-024), trevogrumab (REGN1033), and sarconeos (BIO101).
T32 593-636 Sentence denotes Most trials are in phase 1 or phase 2 [19].
T33 637-792 Sentence denotes In addition, outcomes of commonly used treatments (e.g., testosterone, growth hormone, and anabolic steroids) have been rather unsatisfactory [4,20,21,22].
T34 793-937 Sentence denotes Therefore, the most appropriate strategies for preventing and treating sarcopenia are limited to physical exercise and protein-rich diet [6,21].
T35 938-1029 Sentence denotes Nevertheless, old people tend to be less compliant with physical activity programs [23,24].
T36 1030-1294 Sentence denotes Meanwhile, problems of the gastrointestinal (GI) tract that develop during advanced age (e.g., loss of teeth, taste, smell, and decreased absorption) as well as anabolic resistance of aged muscle limit potential benefits of protein-rich food in this group [25,26].
T37 1295-1492 Sentence denotes Therefore, it is of importance to search for novel preventive and curative strategies for sarcopenia, which can take into account the multifactorial nature of aging-related skeletal muscle failure.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
106 708-722 Gene denotes growth hormone Gene:81668
107 1114-1117 Gene denotes age Gene:81759
108 141-144 Gene denotes age Gene:81759
109 336-342 Species denotes people Tax:9606
110 382-390 Species denotes patients Tax:9606
111 956-962 Species denotes people Tax:9606
112 503-513 Chemical denotes bimagrumab MESH:C000596367
113 515-521 Chemical denotes BYM338 MESH:C000596367
114 524-533 Chemical denotes enobasarm
115 535-542 Chemical denotes GTx-024 MESH:C547106
116 545-556 Chemical denotes trevogrumab
117 558-566 Chemical denotes REGN1033
118 694-706 Chemical denotes testosterone MESH:D013739
119 737-745 Chemical denotes steroids MESH:D013256
120 146-156 Disease denotes sarcopenia MESH:D055948
121 396-404 Disease denotes COVID-19 MESH:C000657245
122 864-874 Disease denotes sarcopenia MESH:D055948
123 1125-1138 Disease denotes loss of teeth MESH:D018677
124 1385-1395 Disease denotes sarcopenia MESH:D055948
125 1468-1491 Disease denotes skeletal muscle failure MESH:D017093