PMC:7601109 / 42316-43404 JSONTXT

{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T56","span":{"begin":579,"end":584},"obj":"Body_part"},{"id":"T57","span":{"begin":904,"end":918},"obj":"Body_part"},{"id":"T58","span":{"begin":912,"end":918},"obj":"Body_part"},{"id":"T59","span":{"begin":1050,"end":1055},"obj":"Body_part"}],"attributes":[{"id":"A56","pred":"uberon_id","subj":"T56","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"A57","pred":"uberon_id","subj":"T57","obj":"http://purl.obolibrary.org/obo/UBERON_0001013"},{"id":"A58","pred":"uberon_id","subj":"T58","obj":"http://purl.obolibrary.org/obo/UBERON_0000479"},{"id":"A59","pred":"uberon_id","subj":"T59","obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"The molecular events involved in the effect of bee products on catabolic genes and anabolic resistance in skeletal muscle could be much related to their hypoglycemic effects, which positively affect the quality of skeletal muscle. Evidence signifies a positive effect of royal jelly acid (10-HDA) on inflammation and autophagy via upregulation of AMPK, which subsequently alters NF-κB and NLRP3 inflammasome-IL1β signaling [129]. Positive effects of whole royal jelly on skeletal muscle are associated with improved insulin signaling [96,100]. In one study, royal jelly improved serum IGF-1 levels in aged rats and increased AKT signaling in satellite cells extracted from aged rats in a separate in vitro investigation [96]. In another study, royal jelly decreased fat mass and improved anabolic resistance in the skeletal muscle of old obese rats on HFD via downregulation of inflammatory responses in adipose tissue as indicated by downregulation of TNFR1. This effect was associated with enhanced sensitivity to insulin—portrayed by reduction of serum insulin level and HOMA-IR [100]."}

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{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T627","span":{"begin":271,"end":282},"obj":"Chemical"},{"id":"T628","span":{"begin":283,"end":287},"obj":"Chemical"},{"id":"T629","span":{"begin":292,"end":295},"obj":"Chemical"},{"id":"T630","span":{"begin":379,"end":381},"obj":"Chemical"},{"id":"T633","span":{"begin":456,"end":467},"obj":"Chemical"},{"id":"T634","span":{"begin":516,"end":523},"obj":"Chemical"},{"id":"T635","span":{"begin":558,"end":569},"obj":"Chemical"},{"id":"T636","span":{"begin":744,"end":755},"obj":"Chemical"},{"id":"T637","span":{"begin":1016,"end":1023},"obj":"Chemical"},{"id":"T638","span":{"begin":1056,"end":1063},"obj":"Chemical"},{"id":"T639","span":{"begin":1079,"end":1081},"obj":"Chemical"}],"attributes":[{"id":"A627","pred":"chebi_id","subj":"T627","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A628","pred":"chebi_id","subj":"T628","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A629","pred":"chebi_id","subj":"T629","obj":"http://purl.obolibrary.org/obo/CHEBI_17314"},{"id":"A630","pred":"chebi_id","subj":"T630","obj":"http://purl.obolibrary.org/obo/CHEBI_141424"},{"id":"A631","pred":"chebi_id","subj":"T630","obj":"http://purl.obolibrary.org/obo/CHEBI_25573"},{"id":"A632","pred":"chebi_id","subj":"T630","obj":"http://purl.obolibrary.org/obo/CHEBI_1224"},{"id":"A633","pred":"chebi_id","subj":"T633","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A634","pred":"chebi_id","subj":"T634","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A635","pred":"chebi_id","subj":"T635","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A636","pred":"chebi_id","subj":"T636","obj":"http://purl.obolibrary.org/obo/CHEBI_78665"},{"id":"A637","pred":"chebi_id","subj":"T637","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A638","pred":"chebi_id","subj":"T638","obj":"http://purl.obolibrary.org/obo/CHEBI_145810"},{"id":"A639","pred":"chebi_id","subj":"T639","obj":"http://purl.obolibrary.org/obo/CHEBI_74061"}],"text":"The molecular events involved in the effect of bee products on catabolic genes and anabolic resistance in skeletal muscle could be much related to their hypoglycemic effects, which positively affect the quality of skeletal muscle. Evidence signifies a positive effect of royal jelly acid (10-HDA) on inflammation and autophagy via upregulation of AMPK, which subsequently alters NF-κB and NLRP3 inflammasome-IL1β signaling [129]. Positive effects of whole royal jelly on skeletal muscle are associated with improved insulin signaling [96,100]. In one study, royal jelly improved serum IGF-1 levels in aged rats and increased AKT signaling in satellite cells extracted from aged rats in a separate in vitro investigation [96]. In another study, royal jelly decreased fat mass and improved anabolic resistance in the skeletal muscle of old obese rats on HFD via downregulation of inflammatory responses in adipose tissue as indicated by downregulation of TNFR1. This effect was associated with enhanced sensitivity to insulin—portrayed by reduction of serum insulin level and HOMA-IR [100]."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T138","span":{"begin":300,"end":312},"obj":"http://purl.obolibrary.org/obo/GO_0006954"},{"id":"T139","span":{"begin":317,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0016236"},{"id":"T140","span":{"begin":317,"end":326},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T141","span":{"begin":347,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_0050405"},{"id":"T142","span":{"begin":347,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_0047322"},{"id":"T143","span":{"begin":347,"end":351},"obj":"http://purl.obolibrary.org/obo/GO_0004691"},{"id":"T144","span":{"begin":413,"end":422},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T145","span":{"begin":524,"end":533},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T146","span":{"begin":625,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0043491"},{"id":"T147","span":{"begin":629,"end":638},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T148","span":{"begin":860,"end":900},"obj":"http://purl.obolibrary.org/obo/GO_0050728"}],"text":"The molecular events involved in the effect of bee products on catabolic genes and anabolic resistance in skeletal muscle could be much related to their hypoglycemic effects, which positively affect the quality of skeletal muscle. Evidence signifies a positive effect of royal jelly acid (10-HDA) on inflammation and autophagy via upregulation of AMPK, which subsequently alters NF-κB and NLRP3 inflammasome-IL1β signaling [129]. Positive effects of whole royal jelly on skeletal muscle are associated with improved insulin signaling [96,100]. In one study, royal jelly improved serum IGF-1 levels in aged rats and increased AKT signaling in satellite cells extracted from aged rats in a separate in vitro investigation [96]. In another study, royal jelly decreased fat mass and improved anabolic resistance in the skeletal muscle of old obese rats on HFD via downregulation of inflammatory responses in adipose tissue as indicated by downregulation of TNFR1. This effect was associated with enhanced sensitivity to insulin—portrayed by reduction of serum insulin level and HOMA-IR [100]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T261","span":{"begin":0,"end":230},"obj":"Sentence"},{"id":"T262","span":{"begin":231,"end":429},"obj":"Sentence"},{"id":"T263","span":{"begin":430,"end":543},"obj":"Sentence"},{"id":"T264","span":{"begin":544,"end":725},"obj":"Sentence"},{"id":"T265","span":{"begin":726,"end":959},"obj":"Sentence"},{"id":"T266","span":{"begin":960,"end":1088},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The molecular events involved in the effect of bee products on catabolic genes and anabolic resistance in skeletal muscle could be much related to their hypoglycemic effects, which positively affect the quality of skeletal muscle. Evidence signifies a positive effect of royal jelly acid (10-HDA) on inflammation and autophagy via upregulation of AMPK, which subsequently alters NF-κB and NLRP3 inflammasome-IL1β signaling [129]. Positive effects of whole royal jelly on skeletal muscle are associated with improved insulin signaling [96,100]. In one study, royal jelly improved serum IGF-1 levels in aged rats and increased AKT signaling in satellite cells extracted from aged rats in a separate in vitro investigation [96]. In another study, royal jelly decreased fat mass and improved anabolic resistance in the skeletal muscle of old obese rats on HFD via downregulation of inflammatory responses in adipose tissue as indicated by downregulation of TNFR1. This effect was associated with enhanced sensitivity to insulin—portrayed by reduction of serum insulin level and HOMA-IR [100]."}

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