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PMC:7601109 / 26671-29851 JSONTXT

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LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T19 626-630 Body_part denotes head http://purl.obolibrary.org/obo/UBERON_0000033
T20 1617-1631 Body_part denotes adipose tissue http://purl.obolibrary.org/obo/UBERON_0001013
T21 1625-1631 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T22 1929-1942 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T23 2027-2036 Body_part denotes plantaris http://purl.obolibrary.org/obo/UBERON_0011905
T24 2041-2054 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T25 2108-2121 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T26 2751-2755 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T27 2880-2893 Body_part denotes gastrocnemius http://purl.obolibrary.org/obo/UBERON_0001388
T28 2926-2930 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913
T29 2935-2939 Body_part denotes milk http://purl.obolibrary.org/obo/UBERON_0001913

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T77157 511-520 Body_part denotes galactose http://purl.org/sig/ont/fma/fma82794
T81617 626-630 Body_part denotes head http://purl.org/sig/ont/fma/fma7154
T98175 1054-1059 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T98501 1085-1091 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T80318 1131-1144 Body_part denotes muscle fibers http://purl.org/sig/ont/fma/fma67328
T95214 1188-1194 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T62514 1274-1280 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T15725 1291-1295 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T95609 1343-1349 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T64407 1440-1446 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T56094 1490-1500 Body_part denotes fatty acid http://purl.org/sig/ont/fma/fma82738
T62805 1617-1631 Body_part denotes adipose tissue http://purl.org/sig/ont/fma/fma20110
T76859 1697-1703 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T67627 1815-1821 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T10711 1869-1873 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T85060 1929-1949 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T86696 2027-2036 Body_part denotes plantaris http://purl.org/sig/ont/fma/fma22543
T24345 2041-2054 Body_part denotes gastrocnemius http://purl.org/sig/ont/fma/fma22541
T13279 2055-2062 Body_part denotes muscles http://purl.org/sig/ont/fma/fma32558
T35031 2108-2128 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T96042 2304-2310 Body_part denotes muscle http://purl.org/sig/ont/fma/fma32558
T51154 2425-2429 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T80466 2430-2437 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T33356 2453-2457 Body_part denotes body http://purl.org/sig/ont/fma/fma256135
T49009 2751-2755 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100
T23113 2807-2818 Body_part denotes fatty acids http://purl.org/sig/ont/fma/fma82738
T68001 2880-2900 Body_part denotes gastrocnemius muscle http://purl.org/sig/ont/fma/fma22541
T88335 2926-2930 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100
T53575 2935-2939 Body_part denotes milk http://purl.org/sig/ont/fma/fma62100

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T61 20-30 Disease denotes Sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T62 169-179 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T63 349-359 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T64 1400-1410 Disease denotes sarcopenia http://purl.obolibrary.org/obo/MONDO_0006516
T65 2066-2078 Disease denotes malnourished http://purl.obolibrary.org/obo/MONDO_0006873
T66 2182-2190 Disease denotes ischemia http://purl.obolibrary.org/obo/MONDO_0005053

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T225 104-110 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T226 529-534 http://purl.obolibrary.org/obo/CLO_0007836 denotes mouse
T227 626-630 http://purl.obolibrary.org/obo/UBERON_0000033 denotes head
T228 626-630 http://www.ebi.ac.uk/efo/EFO_0000964 denotes head
T229 810-815 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tests
T230 1076-1091 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T231 1076-1091 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T232 1076-1091 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T233 1131-1137 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T234 1131-1137 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T235 1131-1137 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T236 1131-1137 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T237 1179-1194 http://purl.obolibrary.org/obo/UBERON_0001134 denotes skeletal muscle
T238 1179-1194 http://purl.obolibrary.org/obo/UBERON_0014892 denotes skeletal muscle
T239 1179-1194 http://www.ebi.ac.uk/efo/EFO_0000888 denotes skeletal muscle
T240 1274-1280 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T241 1274-1280 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T242 1274-1280 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T243 1274-1280 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T244 1281-1295 http://purl.obolibrary.org/obo/CL_0000514 denotes satellite cell
T245 1343-1349 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T246 1343-1349 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T247 1343-1349 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T248 1343-1349 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T249 1376-1381 http://purl.obolibrary.org/obo/OGG_0000000002 denotes genes
T250 1440-1446 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T251 1440-1446 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T252 1440-1446 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T253 1440-1446 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T254 1484-1485 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T255 1541-1545 http://purl.obolibrary.org/obo/UBERON_0003101 denotes male
T256 1541-1545 http://www.ebi.ac.uk/efo/EFO_0000970 denotes male
T257 1546-1553 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animals
T258 1562-1569 http://purl.obolibrary.org/obo/UBERON_0003100 denotes females
T259 1617-1631 http://purl.obolibrary.org/obo/UBERON_0001013 denotes adipose tissue
T260 1635-1641 http://purl.obolibrary.org/obo/UBERON_0003100 denotes female
T261 1697-1703 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T262 1697-1703 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T263 1697-1703 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T264 1697-1703 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T265 1741-1747 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes humans
T266 1815-1821 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T267 1815-1821 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T268 1815-1821 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T269 1815-1821 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T270 1943-1949 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T271 1943-1949 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T272 1943-1949 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T273 1943-1949 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T274 2055-2062 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscles
T275 2089-2091 http://purl.obolibrary.org/obo/CLO_0001313 denotes 36
T276 2122-2128 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T277 2122-2128 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T278 2122-2128 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T279 2122-2128 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T280 2218-2219 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T281 2304-2310 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T282 2304-2310 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T283 2304-2310 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T284 2304-2310 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle
T285 2563-2569 http://purl.obolibrary.org/obo/UBERON_0002548 denotes larvae
T286 2677-2681 http://purl.obolibrary.org/obo/NCBITaxon_117565 denotes fish
T287 2731-2734 http://purl.obolibrary.org/obo/UBERON_0001013 denotes fat
T288 2894-2900 http://purl.obolibrary.org/obo/UBERON_0001630 denotes muscle
T289 2894-2900 http://purl.obolibrary.org/obo/UBERON_0005090 denotes muscle
T290 2894-2900 http://www.ebi.ac.uk/efo/EFO_0000801 denotes muscle
T291 2894-2900 http://www.ebi.ac.uk/efo/EFO_0001949 denotes muscle

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T414 204-215 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T415 424-435 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T416 511-520 Chemical denotes galactose http://purl.obolibrary.org/obo/CHEBI_28260
T417 833-844 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T418 996-1001 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T419 1032-1043 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T420 1054-1059 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T421 1479-1482 Chemical denotes HDA http://purl.obolibrary.org/obo/CHEBI_17314
T422 1490-1500 Chemical denotes fatty acid http://purl.obolibrary.org/obo/CHEBI_35366
T423 1496-1500 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T424 1504-1515 Chemical denotes royal jelly http://purl.obolibrary.org/obo/CHEBI_78665
T425 1541-1545 Chemical denotes male http://purl.obolibrary.org/obo/CHEBI_30780
T426 1583-1586 Chemical denotes HDA http://purl.obolibrary.org/obo/CHEBI_17314
T427 2094-2098 Chemical denotes CAPE http://purl.obolibrary.org/obo/CHEBI_8062
T428 2430-2437 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T429 2791-2818 Chemical denotes polyunsaturated fatty acids http://purl.obolibrary.org/obo/CHEBI_26208
T430 2807-2818 Chemical denotes fatty acids http://purl.obolibrary.org/obo/CHEBI_35366
T431 2813-2818 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T432 2820-2824 Chemical denotes PUFA http://purl.obolibrary.org/obo/CHEBI_26208|http://purl.obolibrary.org/obo/CHEBI_76567
T434 2830-2841 Chemical denotes polyphenols http://purl.obolibrary.org/obo/CHEBI_26195
T435 2954-2958 Chemical denotes PUFA http://purl.obolibrary.org/obo/CHEBI_26208|http://purl.obolibrary.org/obo/CHEBI_76567

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T35 544-549 http://purl.obolibrary.org/obo/GO_0007568 denotes aging
T36 946-954 http://purl.obolibrary.org/obo/GO_0036268 denotes swimming
T37 975-983 http://purl.obolibrary.org/obo/GO_0036268 denotes swimming
T38 2497-2503 http://purl.obolibrary.org/obo/GO_0040007 denotes growth

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T30 661-683 Phenotype denotes vestibular dysfunction http://purl.obolibrary.org/obo/HP_0001751
T31 1054-1091 Phenotype denotes lipid accumulation in skeletal muscle http://purl.obolibrary.org/obo/HP_0009058

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T174 0-2 Sentence denotes 3.
T175 3-92 Sentence denotes Evidence of Anti-Sarcopenia Effects of Bee Products from Preclinical and Clinical Studies
T176 93-391 Sentence denotes Though few animal models were used to examine the effect of bee products on sarcopenia, findings indicate that royal jelly, propolis, and bee pollen can induce both structural and symptomatic improvements and reduce behavioral dysfunctions associated with sarcopenia in rodents (Figure 1, Panel C).
T177 392-821 Sentence denotes Both crude and protease-treated royal jelly (pRJ) significantly delayed age-related impairment of motor functions in d-galactose induced mouse model of aging [95], naturally aged sarcopenic mice [96], and in genetically heterogeneous head tilt (HET) mice—which exhibit vestibular dysfunction, imbalanced position, and inability to swim—by improving performance on grip strength, wire hang, horizontal bar, and rotarod tests [97].
T178 822-1018 Sentence denotes Similarly, royal jelly improved physical performance in aged rodents—it significantly increased the number of crossings and swimming speed and prolonged swimming distance in water maze [96,98,99].
T179 1019-1435 Sentence denotes In addition, royal jelly decreased lipid accumulation in skeletal muscle [100], positively improved the size of muscle fibers, lowered age-related reduction of skeletal muscle weight [95,96,97,100], increased the differentiation and proliferation rate of muscle satellite cell, improved the regenerative capacity of injured muscle, and suppressed catabolic genes in aged mice with sarcopenia and in HET mice [96,97].
T180 1436-1570 Sentence denotes The muscle mass-accelerating effects of 10-HDA, a key fatty acid in royal jelly, were more pronounced in male animals than in females.
T181 1571-1652 Sentence denotes However, 10-HDA mitigated the accumulation of adipose tissue in female mice [54].
T182 1653-1777 Sentence denotes It is note-worthy that pRJ had no effect on muscle strength and physical performance in humans aged 70 years and above [59].
T183 1778-1848 Sentence denotes The effects of other bee products on muscle mass were mostly positive.
T184 1849-1984 Sentence denotes Bee pollen promoted body weight regain and increased the relative weight of the gastrocnemius muscle in eccentric exercising rats [90].
T185 1985-2093 Sentence denotes It also increased the absolute weights of plantaris and gastrocnemius muscles in malnourished old rats [36].
T186 2094-2217 Sentence denotes CAPE restored gastrocnemius muscle mass in rats on exhaustive exercise and in rats with ischemia reperfusion [101,102,103].
T187 2218-2355 Sentence denotes A study reported no effect of propolis ethanolic extracts (4% of diet) on the size of muscle or their level of myostatin in Nile tilapia.
T188 2356-2628 Sentence denotes However, another interesting study reported significant increases in body protein deposition and body condition factor—an estimate of future growth, survival, and reproductive potential—in Nile tilapia post-larvae and fingerlings receiving 2.6 g propolis/kg of feed [104].
T189 2629-2682 Sentence denotes Nonetheless, these findings seem to be bound to fish.
T190 2683-2970 Sentence denotes Interestingly, supplementing obese rats on high fat diet (HFD) with milk naturally enriched with long-chain polyunsaturated fatty acids (PUFA) and polyphenols from propolis significantly increased gastrocnemius muscle mass compared with whole milk and milk enriched with PUFA only [105].
T191 2971-3032 Sentence denotes Several molecular changes were associated with these effects.
T192 3033-3076 Sentence denotes We elaborate on these changes in Section 4.
T193 3077-3180 Sentence denotes Table 1 presents more details on treatments with bee products and key findings of the relevant studies.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
513 20-30 Disease denotes Sarcopenia MESH:D055948
538 626-635 Gene denotes head tilt Gene:224480
539 1154-1157 Gene denotes age Gene:19703
540 464-467 Gene denotes age Gene:19703
541 529-534 Species denotes mouse Tax:10090
542 582-586 Species denotes mice Tax:10090
543 642-646 Species denotes mice Tax:10090
544 1390-1394 Species denotes mice Tax:10090
545 1422-1426 Species denotes mice Tax:10090
546 1642-1646 Species denotes mice Tax:10090
547 1741-1747 Species denotes humans Tax:9606
548 509-520 Chemical denotes d-galactose MESH:D005690
549 833-844 Chemical denotes royal jelly MESH:C058787
550 996-1001 Chemical denotes water MESH:D014867
551 1032-1043 Chemical denotes royal jelly MESH:C058787
552 1054-1059 Chemical denotes lipid MESH:D008055
553 1476-1482 Chemical denotes 10-HDA
554 1490-1500 Chemical denotes fatty acid MESH:D005227
555 1580-1586 Chemical denotes 10-HDA
556 169-179 Disease denotes sarcopenia MESH:D055948
557 309-332 Disease denotes behavioral dysfunctions MESH:D001523
558 349-359 Disease denotes sarcopenia MESH:D055948
559 661-683 Disease denotes vestibular dysfunction MESH:D015837
560 710-719 Disease denotes inability MESH:D007319
561 1400-1410 Disease denotes sarcopenia MESH:D055948
577 2731-2734 Gene denotes fat Gene:83720
578 2329-2338 Gene denotes myostatin Gene:17700
579 1974-1978 Species denotes rats Tax:10116
580 2083-2087 Species denotes rats Tax:10116
581 2137-2141 Species denotes rats Tax:10116
582 2172-2176 Species denotes rats Tax:10116
583 2342-2354 Species denotes Nile tilapia Tax:8128
584 2545-2557 Species denotes Nile tilapia Tax:8128
585 2718-2722 Species denotes rats Tax:10116
586 2094-2098 Chemical denotes CAPE MESH:C055494
587 2780-2818 Chemical denotes long-chain polyunsaturated fatty acids
588 2820-2824 Chemical denotes PUFA MESH:D005231
589 2830-2841 Chemical denotes polyphenols MESH:D059808
590 2182-2190 Disease denotes ischemia MESH:D007511
591 2712-2717 Disease denotes obese MESH:D009765