PMC:7600245 / 97003-97620 JSONTXT

{"project":"LitCovid_Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":81,"end":88},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T2","span":{"begin":81,"end":88},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"},{"id":"T3","span":{"begin":113,"end":121},"obj":"https://glytoucan.org/Structures/Glycans/G00021MO"},{"id":"T4","span":{"begin":113,"end":121},"obj":"https://glytoucan.org/Structures/Glycans/G54161DR"}],"text":"Therapy Type Mechanism No. of Interventional Clinical Trials b\nUnfractionated heparin or Low molecular weight heparins (Enoxaparin, Dalteparin, Tinzaparin, and others) Sulfated glycosaminoglycans Activation of antithrombin to inhibit thrombin and factor Xa ~23\nAspirin (Acetylsalicylic acid) Small molecule Cyclo-oxygenase inhibitor ~8\nRivaroxaban(Xarelto) Small molecule Direct factor Xa inhibitor ~5\nDipyridamole(Aggrenox) Small molecule Nucleoside transport inhibitor and a phosphodiesterase 3 inhibitor ~3\nClopidogrel(Plavix) Small molecule Irreversible adenosine diphosphate receptor blocker ~3"}

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T449","span":{"begin":81,"end":88},"obj":"Body_part"},{"id":"T450","span":{"begin":113,"end":121},"obj":"Body_part"},{"id":"T451","span":{"begin":181,"end":199},"obj":"Body_part"}],"attributes":[{"id":"A449","pred":"fma_id","subj":"T449","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A450","pred":"fma_id","subj":"T450","obj":"http://purl.org/sig/ont/fma/fma82839"},{"id":"A451","pred":"fma_id","subj":"T451","obj":"http://purl.org/sig/ont/fma/fma63011"}],"text":"Therapy Type Mechanism No. of Interventional Clinical Trials b\nUnfractionated heparin or Low molecular weight heparins (Enoxaparin, Dalteparin, Tinzaparin, and others) Sulfated glycosaminoglycans Activation of antithrombin to inhibit thrombin and factor Xa ~23\nAspirin (Acetylsalicylic acid) Small molecule Cyclo-oxygenase inhibitor ~8\nRivaroxaban(Xarelto) Small molecule Direct factor Xa inhibitor ~5\nDipyridamole(Aggrenox) Small molecule Nucleoside transport inhibitor and a phosphodiesterase 3 inhibitor ~3\nClopidogrel(Plavix) Small molecule Irreversible adenosine diphosphate receptor blocker ~3"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T965","span":{"begin":64,"end":65},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T966","span":{"begin":201,"end":211},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T967","span":{"begin":489,"end":490},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Therapy Type Mechanism No. of Interventional Clinical Trials b\nUnfractionated heparin or Low molecular weight heparins (Enoxaparin, Dalteparin, Tinzaparin, and others) Sulfated glycosaminoglycans Activation of antithrombin to inhibit thrombin and factor Xa ~23\nAspirin (Acetylsalicylic acid) Small molecule Cyclo-oxygenase inhibitor ~8\nRivaroxaban(Xarelto) Small molecule Direct factor Xa inhibitor ~5\nDipyridamole(Aggrenox) Small molecule Nucleoside transport inhibitor and a phosphodiesterase 3 inhibitor ~3\nClopidogrel(Plavix) Small molecule Irreversible adenosine diphosphate receptor blocker ~3"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T734","span":{"begin":81,"end":88},"obj":"Chemical"},{"id":"T735","span":{"begin":113,"end":121},"obj":"Chemical"},{"id":"T736","span":{"begin":123,"end":133},"obj":"Chemical"},{"id":"T737","span":{"begin":172,"end":199},"obj":"Chemical"},{"id":"T738","span":{"begin":181,"end":199},"obj":"Chemical"},{"id":"T739","span":{"begin":267,"end":274},"obj":"Chemical"},{"id":"T740","span":{"begin":276,"end":296},"obj":"Chemical"},{"id":"T741","span":{"begin":292,"end":296},"obj":"Chemical"},{"id":"T742","span":{"begin":305,"end":313},"obj":"Chemical"},{"id":"T743","span":{"begin":331,"end":340},"obj":"Chemical"},{"id":"T744","span":{"begin":357,"end":364},"obj":"Chemical"},{"id":"T745","span":{"begin":373,"end":381},"obj":"Chemical"},{"id":"T746","span":{"begin":390,"end":409},"obj":"Chemical"},{"id":"T747","span":{"begin":400,"end":409},"obj":"Chemical"},{"id":"T748","span":{"begin":444,"end":452},"obj":"Chemical"},{"id":"T749","span":{"begin":454,"end":464},"obj":"Chemical"},{"id":"T750","span":{"begin":475,"end":484},"obj":"Chemical"},{"id":"T751","span":{"begin":511,"end":520},"obj":"Chemical"},{"id":"T90414","span":{"begin":537,"end":543},"obj":"Chemical"},{"id":"T753","span":{"begin":552,"end":560},"obj":"Chemical"},{"id":"T754","span":{"begin":575,"end":584},"obj":"Chemical"},{"id":"T755","span":{"begin":585,"end":596},"obj":"Chemical"}],"attributes":[{"id":"A734","pred":"chebi_id","subj":"T734","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A735","pred":"chebi_id","subj":"T735","obj":"http://purl.obolibrary.org/obo/CHEBI_24505"},{"id":"A736","pred":"chebi_id","subj":"T736","obj":"http://purl.obolibrary.org/obo/CHEBI_28304"},{"id":"A737","pred":"chebi_id","subj":"T737","obj":"http://purl.obolibrary.org/obo/CHEBI_35722"},{"id":"A738","pred":"chebi_id","subj":"T738","obj":"http://purl.obolibrary.org/obo/CHEBI_18085"},{"id":"A739","pred":"chebi_id","subj":"T739","obj":"http://purl.obolibrary.org/obo/CHEBI_15365"},{"id":"A740","pred":"chebi_id","subj":"T740","obj":"http://purl.obolibrary.org/obo/CHEBI_15365"},{"id":"A741","pred":"chebi_id","subj":"T741","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A742","pred":"chebi_id","subj":"T742","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A743","pred":"chebi_id","subj":"T743","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A744","pred":"chebi_id","subj":"T744","obj":"http://purl.obolibrary.org/obo/CHEBI_68579"},{"id":"A745","pred":"chebi_id","subj":"T745","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A746","pred":"chebi_id","subj":"T746","obj":"http://purl.obolibrary.org/obo/CHEBI_68581"},{"id":"A747","pred":"chebi_id","subj":"T747","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A748","pred":"chebi_id","subj":"T748","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A749","pred":"chebi_id","subj":"T749","obj":"http://purl.obolibrary.org/obo/CHEBI_33838"},{"id":"A750","pred":"chebi_id","subj":"T750","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A751","pred":"chebi_id","subj":"T751","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A752","pred":"chebi_id","subj":"T90414","obj":"http://purl.obolibrary.org/obo/CHEBI_3759"},{"id":"A753","pred":"chebi_id","subj":"T753","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A754","pred":"chebi_id","subj":"T754","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A755","pred":"chebi_id","subj":"T755","obj":"http://purl.obolibrary.org/obo/CHEBI_18361"},{"id":"A756","pred":"chebi_id","subj":"T755","obj":"http://purl.obolibrary.org/obo/CHEBI_33019"}],"text":"Therapy Type Mechanism No. of Interventional Clinical Trials b\nUnfractionated heparin or Low molecular weight heparins (Enoxaparin, Dalteparin, Tinzaparin, and others) Sulfated glycosaminoglycans Activation of antithrombin to inhibit thrombin and factor Xa ~23\nAspirin (Acetylsalicylic acid) Small molecule Cyclo-oxygenase inhibitor ~8\nRivaroxaban(Xarelto) Small molecule Direct factor Xa inhibitor ~5\nDipyridamole(Aggrenox) Small molecule Nucleoside transport inhibitor and a phosphodiesterase 3 inhibitor ~3\nClopidogrel(Plavix) Small molecule Irreversible adenosine diphosphate receptor blocker ~3"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T194","span":{"begin":454,"end":474},"obj":"http://purl.obolibrary.org/obo/GO_0015858"},{"id":"T195","span":{"begin":465,"end":474},"obj":"http://purl.obolibrary.org/obo/GO_0006810"}],"text":"Therapy Type Mechanism No. of Interventional Clinical Trials b\nUnfractionated heparin or Low molecular weight heparins (Enoxaparin, Dalteparin, Tinzaparin, and others) Sulfated glycosaminoglycans Activation of antithrombin to inhibit thrombin and factor Xa ~23\nAspirin (Acetylsalicylic acid) Small molecule Cyclo-oxygenase inhibitor ~8\nRivaroxaban(Xarelto) Small molecule Direct factor Xa inhibitor ~5\nDipyridamole(Aggrenox) Small molecule Nucleoside transport inhibitor and a phosphodiesterase 3 inhibitor ~3\nClopidogrel(Plavix) Small molecule Irreversible adenosine diphosphate receptor blocker ~3"}

{"project":"LitCovid-sentences","denotations":[{"id":"T805","span":{"begin":0,"end":65},"obj":"Sentence"},{"id":"T806","span":{"begin":66,"end":266},"obj":"Sentence"},{"id":"T807","span":{"begin":267,"end":344},"obj":"Sentence"},{"id":"T808","span":{"begin":345,"end":413},"obj":"Sentence"},{"id":"T809","span":{"begin":414,"end":524},"obj":"Sentence"},{"id":"T810","span":{"begin":525,"end":617},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Therapy Type Mechanism No. of Interventional Clinical Trials b\nUnfractionated heparin or Low molecular weight heparins (Enoxaparin, Dalteparin, Tinzaparin, and others) Sulfated glycosaminoglycans Activation of antithrombin to inhibit thrombin and factor Xa ~23\nAspirin (Acetylsalicylic acid) Small molecule Cyclo-oxygenase inhibitor ~8\nRivaroxaban(Xarelto) Small molecule Direct factor Xa inhibitor ~5\nDipyridamole(Aggrenox) Small molecule Nucleoside transport inhibitor and a phosphodiesterase 3 inhibitor ~3\nClopidogrel(Plavix) Small molecule Irreversible adenosine diphosphate receptor blocker ~3"}

{"project":"LitCovid-PubTator","denotations":[{"id":"4100","span":{"begin":215,"end":227},"obj":"Gene"},{"id":"4101","span":{"begin":239,"end":247},"obj":"Gene"},{"id":"4102","span":{"begin":81,"end":88},"obj":"Chemical"},{"id":"4103","span":{"begin":575,"end":584},"obj":"Chemical"}],"attributes":[{"id":"A4100","pred":"tao:has_database_id","subj":"4100","obj":"Gene:462"},{"id":"A4101","pred":"tao:has_database_id","subj":"4101","obj":"Gene:2147"},{"id":"A4102","pred":"tao:has_database_id","subj":"4102","obj":"MESH:D006493"},{"id":"A4103","pred":"tao:has_database_id","subj":"4103","obj":"MESH:D000241"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Therapy Type Mechanism No. of Interventional Clinical Trials b\nUnfractionated heparin or Low molecular weight heparins (Enoxaparin, Dalteparin, Tinzaparin, and others) Sulfated glycosaminoglycans Activation of antithrombin to inhibit thrombin and factor Xa ~23\nAspirin (Acetylsalicylic acid) Small molecule Cyclo-oxygenase inhibitor ~8\nRivaroxaban(Xarelto) Small molecule Direct factor Xa inhibitor ~5\nDipyridamole(Aggrenox) Small molecule Nucleoside transport inhibitor and a phosphodiesterase 3 inhibitor ~3\nClopidogrel(Plavix) Small molecule Irreversible adenosine diphosphate receptor blocker ~3"}