PMC:7600245 / 93501-94060 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T430","span":{"begin":192,"end":204},"obj":"Body_part"}],"attributes":[{"id":"A430","pred":"fma_id","subj":"T430","obj":"http://purl.org/sig/ont/fma/fma63849"}],"text":"(A) The chemical structure of investigational drug VERU-111. The drug exhibits broad antiviral activity because it disrupts the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. It also promotes strong anti-inflammatory effects. (B) The chemical structures of leflunomide and its active metabolite teriflunomide. Their potential therapeutic values in COVID-19 patients are attributed to antiviral effects by dihydroorotate dehydrogenase inhibition and to anti-inflammatory effects."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T428","span":{"begin":174,"end":178},"obj":"Disease"},{"id":"T429","span":{"begin":245,"end":254},"obj":"Disease"},{"id":"T430","span":{"begin":429,"end":437},"obj":"Disease"}],"attributes":[{"id":"A428","pred":"mondo_id","subj":"T428","obj":"http://purl.obolibrary.org/obo/MONDO_0005091"},{"id":"A429","pred":"mondo_id","subj":"T429","obj":"http://purl.obolibrary.org/obo/MONDO_0005550"},{"id":"A430","pred":"mondo_id","subj":"T430","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"}],"text":"(A) The chemical structure of investigational drug VERU-111. The drug exhibits broad antiviral activity because it disrupts the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. It also promotes strong anti-inflammatory effects. (B) The chemical structures of leflunomide and its active metabolite teriflunomide. Their potential therapeutic values in COVID-19 patients are attributed to antiviral effects by dihydroorotate dehydrogenase inhibition and to anti-inflammatory effects."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T939","span":{"begin":1,"end":2},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T940","span":{"begin":95,"end":103},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T941","span":{"begin":155,"end":162},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T942","span":{"begin":228,"end":235},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T943","span":{"begin":308,"end":309},"obj":"http://purl.obolibrary.org/obo/CLO_0001021"},{"id":"T944","span":{"begin":358,"end":364},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"(A) The chemical structure of investigational drug VERU-111. The drug exhibits broad antiviral activity because it disrupts the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. It also promotes strong anti-inflammatory effects. (B) The chemical structures of leflunomide and its active metabolite teriflunomide. Their potential therapeutic values in COVID-19 patients are attributed to antiviral effects by dihydroorotate dehydrogenase inhibition and to anti-inflammatory effects."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T37436","span":{"begin":46,"end":50},"obj":"Chemical"},{"id":"T639","span":{"begin":65,"end":69},"obj":"Chemical"},{"id":"T66168","span":{"begin":85,"end":94},"obj":"Chemical"},{"id":"T32746","span":{"begin":338,"end":349},"obj":"Chemical"},{"id":"T99028","span":{"begin":365,"end":375},"obj":"Chemical"},{"id":"T12250","span":{"begin":376,"end":389},"obj":"Chemical"},{"id":"T644","span":{"begin":465,"end":474},"obj":"Chemical"},{"id":"T13026","span":{"begin":486,"end":500},"obj":"Chemical"}],"attributes":[{"id":"A18056","pred":"chebi_id","subj":"T37436","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A89406","pred":"chebi_id","subj":"T639","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A86622","pred":"chebi_id","subj":"T66168","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A30392","pred":"chebi_id","subj":"T32746","obj":"http://purl.obolibrary.org/obo/CHEBI_6402"},{"id":"A58483","pred":"chebi_id","subj":"T99028","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A46538","pred":"chebi_id","subj":"T12250","obj":"http://purl.obolibrary.org/obo/CHEBI_68540"},{"id":"A6536","pred":"chebi_id","subj":"T644","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A61717","pred":"chebi_id","subj":"T13026","obj":"http://purl.obolibrary.org/obo/CHEBI_30867"}],"text":"(A) The chemical structure of investigational drug VERU-111. The drug exhibits broad antiviral activity because it disrupts the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. It also promotes strong anti-inflammatory effects. (B) The chemical structures of leflunomide and its active metabolite teriflunomide. Their potential therapeutic values in COVID-19 patients are attributed to antiviral effects by dihydroorotate dehydrogenase inhibition and to anti-inflammatory effects."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T187","span":{"begin":128,"end":162},"obj":"http://purl.obolibrary.org/obo/GO_0075733"},{"id":"T188","span":{"begin":128,"end":151},"obj":"http://purl.obolibrary.org/obo/GO_0046907"},{"id":"T189","span":{"begin":142,"end":151},"obj":"http://purl.obolibrary.org/obo/GO_0006810"}],"text":"(A) The chemical structure of investigational drug VERU-111. The drug exhibits broad antiviral activity because it disrupts the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. It also promotes strong anti-inflammatory effects. (B) The chemical structures of leflunomide and its active metabolite teriflunomide. Their potential therapeutic values in COVID-19 patients are attributed to antiviral effects by dihydroorotate dehydrogenase inhibition and to anti-inflammatory effects."}

{"project":"LitCovid-sentences","denotations":[{"id":"T755","span":{"begin":61,"end":255},"obj":"Sentence"},{"id":"T756","span":{"begin":256,"end":390},"obj":"Sentence"},{"id":"T757","span":{"begin":391,"end":559},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"(A) The chemical structure of investigational drug VERU-111. The drug exhibits broad antiviral activity because it disrupts the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. It also promotes strong anti-inflammatory effects. (B) The chemical structures of leflunomide and its active metabolite teriflunomide. Their potential therapeutic values in COVID-19 patients are attributed to antiviral effects by dihydroorotate dehydrogenase inhibition and to anti-inflammatory effects."}

{"project":"LitCovid-PubTator","denotations":[{"id":"4030","span":{"begin":486,"end":514},"obj":"Gene"},{"id":"4031","span":{"begin":174,"end":184},"obj":"Species"},{"id":"4032","span":{"begin":438,"end":446},"obj":"Species"},{"id":"4033","span":{"begin":51,"end":59},"obj":"Chemical"},{"id":"4034","span":{"begin":338,"end":349},"obj":"Chemical"},{"id":"4035","span":{"begin":376,"end":389},"obj":"Chemical"},{"id":"4036","span":{"begin":245,"end":254},"obj":"Disease"},{"id":"4037","span":{"begin":429,"end":437},"obj":"Disease"}],"attributes":[{"id":"A4030","pred":"tao:has_database_id","subj":"4030","obj":"Gene:1723"},{"id":"A4031","pred":"tao:has_database_id","subj":"4031","obj":"Tax:2697049"},{"id":"A4032","pred":"tao:has_database_id","subj":"4032","obj":"Tax:9606"},{"id":"A4034","pred":"tao:has_database_id","subj":"4034","obj":"MESH:D000077339"},{"id":"A4035","pred":"tao:has_database_id","subj":"4035","obj":"MESH:C527525"},{"id":"A4036","pred":"tao:has_database_id","subj":"4036","obj":"MESH:D007239"},{"id":"A4037","pred":"tao:has_database_id","subj":"4037","obj":"MESH:C000657245"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"(A) The chemical structure of investigational drug VERU-111. The drug exhibits broad antiviral activity because it disrupts the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. It also promotes strong anti-inflammatory effects. (B) The chemical structures of leflunomide and its active metabolite teriflunomide. Their potential therapeutic values in COVID-19 patients are attributed to antiviral effects by dihydroorotate dehydrogenase inhibition and to anti-inflammatory effects."}