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PMC:7600245 / 75952-78492 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T325 58-62 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T326 479-501 Body_part denotes cell adhesion molecule http://purl.org/sig/ont/fma/fma67214
T327 479-483 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T328 517-544 Body_part denotes vascular smooth muscle cell http://purl.org/sig/ont/fma/fma284560
T329 540-544 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T330 635-643 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T331 660-663 Body_part denotes LDL http://purl.org/sig/ont/fma/fma63170
T332 883-886 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T333 1207-1211 Body_part denotes hand http://purl.org/sig/ont/fma/fma9712
T334 1426-1434 Body_part denotes platelet http://purl.org/sig/ont/fma/fma62851
T335 1451-1456 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T336 1601-1604 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T337 1609-1612 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T338 1695-1700 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T41 58-62 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398
T42 1207-1211 Body_part denotes hand http://purl.obolibrary.org/obo/UBERON_0002398

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T364 737-745 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T365 746-755 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T366 956-965 Disease denotes enteritis http://purl.obolibrary.org/obo/MONDO_0043579
T367 982-994 Disease denotes pseudorabies http://purl.obolibrary.org/obo/MONDO_0005932
T368 1063-1071 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T369 1880-1885 Disease denotes polio http://purl.obolibrary.org/obo/MONDO_0017373
T370 1893-1907 Disease denotes herpes simplex http://purl.obolibrary.org/obo/MONDO_0004609
T371 2049-2055 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502
T372 2421-2429 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T777 79-80 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T778 174-184 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T779 272-282 http://purl.obolibrary.org/obo/CLO_0001658 denotes activities
T780 317-327 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T781 335-336 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T782 340-341 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T783 479-483 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T784 526-544 http://purl.obolibrary.org/obo/CL_0000192 denotes smooth muscle cell
T785 613-621 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T786 951-955 http://purl.obolibrary.org/obo/NCBITaxon_8839 denotes duck
T787 966-971 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T788 995-1000 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T789 1091-1097 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T790 1101-1102 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T791 1226-1227 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T792 1558-1559 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T793 1584-1592 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T794 1613-1620 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T795 1675-1682 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T796 1686-1700 http://purl.obolibrary.org/obo/CL_0000010 denotes cultured cells
T797 1886-1891 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T798 1908-1913 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T799 1939-1944 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T800 1964-1969 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T801 2056-2061 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T802 2153-2158 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T803 2369-2370 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T804 2390-2391 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T805 2411-2417 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T806 2475-2481 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T85105 21-32 Chemical denotes Resveratrol http://purl.obolibrary.org/obo/CHEBI_27881|http://purl.obolibrary.org/obo/CHEBI_45713
T59578 37-46 Chemical denotes Quercetin http://purl.obolibrary.org/obo/CHEBI_16243
T43721 64-75 Chemical denotes resveratrol http://purl.obolibrary.org/obo/CHEBI_27881
T50650 102-110 Chemical denotes stilbene http://purl.obolibrary.org/obo/CHEBI_26775
T79675 134-145 Chemical denotes Resveratrol http://purl.obolibrary.org/obo/CHEBI_27881|http://purl.obolibrary.org/obo/CHEBI_45713
T74290 196-207 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T73538 239-245 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T78854 262-271 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T96300 284-295 Chemical denotes Resveratrol http://purl.obolibrary.org/obo/CHEBI_27881|http://purl.obolibrary.org/obo/CHEBI_45713
T51760 331-333 Chemical denotes NF http://purl.obolibrary.org/obo/CHEBI_141424|http://purl.obolibrary.org/obo/CHEBI_25573|http://purl.obolibrary.org/obo/CHEBI_1224
T90646 493-501 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T395 591-603 Chemical denotes nitric oxide http://purl.obolibrary.org/obo/CHEBI_16480
T396 598-603 Chemical denotes oxide http://purl.obolibrary.org/obo/CHEBI_25741|http://purl.obolibrary.org/obo/CHEBI_29356
T29796 660-663 Chemical denotes LDL http://purl.obolibrary.org/obo/CHEBI_39026
T46687 792-803 Chemical denotes resveratrol http://purl.obolibrary.org/obo/CHEBI_27881
T70346 905-916 Chemical denotes Resveratrol http://purl.obolibrary.org/obo/CHEBI_27881|http://purl.obolibrary.org/obo/CHEBI_45713
T47574 1048-1059 Chemical denotes resveratrol http://purl.obolibrary.org/obo/CHEBI_27881
T403 1213-1222 Chemical denotes quercetin http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694
T87746 1255-1264 Chemical denotes flavonoid http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544
T18882 1288-1299 Chemical denotes resveratrol http://purl.obolibrary.org/obo/CHEBI_27881
T90539 1301-1310 Chemical denotes quercetin http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694
T82583 1321-1332 Chemical denotes antioxidant http://purl.obolibrary.org/obo/CHEBI_22586
T48441 1334-1340 Chemical denotes oxygen http://purl.obolibrary.org/obo/CHEBI_25805
T87394 1402-1411 Chemical denotes Quercetin http://purl.obolibrary.org/obo/CHEBI_16243
T68803 1451-1456 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059
T25270 1534-1543 Chemical denotes quercetin http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694
T84764 1574-1583 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T35973 1601-1604 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T17050 1635-1644 Chemical denotes quercetin http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694
T91467 1823-1832 Chemical denotes Quercetin http://purl.obolibrary.org/obo/CHEBI_16243
T69520 1990-1999 Chemical denotes quercetin http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694
T53088 2075-2084 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T15100 2096-2105 Chemical denotes quercetin http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694
T76164 2245-2255 Chemical denotes flavonoids http://purl.obolibrary.org/obo/CHEBI_47916|http://purl.obolibrary.org/obo/CHEBI_72544
T89668 2297-2307 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T24478 2350-2359 Chemical denotes quercetin http://purl.obolibrary.org/obo/CHEBI_16243|http://purl.obolibrary.org/obo/CHEBI_57694
T431 2487-2491 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T64235 2508-2517 Chemical denotes vitamin C http://purl.obolibrary.org/obo/CHEBI_21241
T434 2508-2515 Chemical denotes vitamin http://purl.obolibrary.org/obo/CHEBI_33229

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T150 479-501 http://purl.obolibrary.org/obo/GO_0098631 denotes cell adhesion molecule
T151 479-492 http://purl.obolibrary.org/obo/GO_0007155 denotes cell adhesion
T152 517-558 http://purl.obolibrary.org/obo/GO_1990874 denotes vascular smooth muscle cell proliferation
T153 526-558 http://purl.obolibrary.org/obo/GO_0048659 denotes smooth muscle cell proliferation
T154 533-558 http://purl.obolibrary.org/obo/GO_0033002 denotes muscle cell proliferation
T155 540-558 http://purl.obolibrary.org/obo/GO_0008283 denotes cell proliferation
T156 591-621 http://purl.obolibrary.org/obo/GO_0051000 denotes nitric oxide synthase activity
T157 635-655 http://purl.obolibrary.org/obo/GO_0070527 denotes platelet aggregation
T158 1426-1446 http://purl.obolibrary.org/obo/GO_0070527 denotes platelet aggregation
T159 1867-1876 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T160 2168-2198 http://purl.obolibrary.org/obo/GO_1903901 denotes inhibits the viral replication
T161 2181-2198 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T162 2181-2198 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T593 0-5 Sentence denotes 4.21.
T594 6-20 Sentence denotes Poly-Alcohols:
T595 21-46 Sentence denotes Resveratrol and Quercetin
T596 47-133 Sentence denotes On the one hand, resveratrol is a natural polyphenolic stilbene derivative (Figure 9).
T597 134-283 Sentence denotes Resveratrol exhibits several biological activities, including antioxidant, antitumor, anti-inflammatory, oxygen scavenging, and antiviral activities.
T598 284-364 Sentence denotes Resveratrol inhibits TNF-induced activation of NF-κB in a dose-dependent manner.
T599 365-434 Sentence denotes Furthermore, it inhibits cyclooxygenase and hydro-peroxidase enzymes.
T600 435-559 Sentence denotes Not only that but it also inhibits vascular cell adhesion molecule expression and vascular smooth muscle cell proliferation.
T601 560-691 Sentence denotes It also stimulates endothelial nitric oxide synthase activity and inhibits platelet aggregation and LDL peroxidation [276,277,278].
T602 692-778 Sentence denotes All these effects are expected to help fight COVID-19 infection and its complications.
T603 779-904 Sentence denotes Importantly, resveratrol significantly inhibited MERS-CoV replication in vitro mainly by inhibiting the RNA production [279].
T604 905-1007 Sentence denotes Resveratrol also inhibited the replication of duck enteritis virus [280] and pseudorabies virus [281].
T605 1008-1193 Sentence denotes Accordingly, the safety and efficacy of resveratrol in COVID-19 patients are being tested in a randomized double-blind, placebo-controlled proof-of-concept trial (NCT04400890; n = 200).
T606 1194-1276 Sentence denotes On the other hand, quercetin is a natural penta-hydroxylated flavonoid (Figure 9).
T607 1277-1401 Sentence denotes Similar to resveratrol, quercetin possesses antioxidant, oxygen scavenging, anti-inflammatory, and cardioprotective effects.
T608 1402-1520 Sentence denotes Quercetin also inhibits platelet aggregation and lipid peroxidation and affects the function of several kinases [282].
T609 1521-1621 Sentence denotes Importantly, quercetin also exhibits a wide spectrum antiviral activity against DNA and RNA viruses.
T610 1622-1701 Sentence denotes For example, quercetin inhibited several respiratory viruses in cultured cells.
T611 1702-1822 Sentence denotes It also inhibited the cytopathic effects of rhinoviruses, echoviruses, coxsackieviruses, and polioviruses [283,284,285].
T612 1823-1976 Sentence denotes Quercetin also significantly reduced plaque formation by polio virus, herpes simplex virus 1, respiratory syncytial virus, and parainfluenza virus [286].
T613 1977-2070 Sentence denotes Furthermore, quercetin inhibited the replication of cytomegalovirus and dengue virus 2 [287].
T614 2071-2238 Sentence denotes The antiviral effects of quercetin are thought to be because it either blocks the virus entry or inhibits the viral replication enzymes, i.e., viral polymerases [288].
T615 2239-2322 Sentence denotes Other flavonoids have recently been reported as potential inhibitors of Mpro [289].
T616 2323-2457 Sentence denotes Accordingly, the effect of quercetin alone as a prophylactic or as a treatment is being tested in COVID-19 patients (NCT04377789; 50).
T617 2458-2540 Sentence denotes It is also being tested with zinc, bromelain, and vitamin C (NCT04468139; n = 60).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2371 6-19 Chemical denotes Poly-Alcohols
2372 21-32 Chemical denotes Resveratrol MESH:D000077185
2373 37-46 Chemical denotes Quercetin MESH:D011794
2392 305-308 Gene denotes TNF Gene:7124
2393 331-336 Gene denotes NF-κB Gene:4790
2394 828-836 Species denotes MERS-CoV Tax:1335626
2395 951-971 Species denotes duck enteritis virus Tax:104388
2396 982-1000 Species denotes pseudorabies virus Tax:10345
2397 1072-1080 Species denotes patients Tax:9606
2398 64-75 Chemical denotes resveratrol MESH:D000077185
2399 89-110 Chemical denotes polyphenolic stilbene
2400 134-145 Chemical denotes Resveratrol MESH:D000077185
2401 239-245 Chemical denotes oxygen MESH:D010100
2402 284-295 Chemical denotes Resveratrol MESH:D000077185
2403 792-803 Chemical denotes resveratrol MESH:D000077185
2404 905-916 Chemical denotes Resveratrol MESH:D000077185
2405 1048-1059 Chemical denotes resveratrol MESH:D000077185
2406 635-655 Disease denotes platelet aggregation MESH:D001791
2407 737-745 Disease denotes COVID-19 MESH:C000657245
2408 746-755 Disease denotes infection MESH:D007239
2409 1063-1071 Disease denotes COVID-19 MESH:C000657245
2433 2311-2315 Gene denotes Mpro Gene:8673700
2434 1893-1915 Species denotes herpes simplex virus 1 Tax:10298
2435 1917-1944 Species denotes respiratory syncytial virus Tax:12814
2436 2430-2438 Species denotes patients Tax:9606
2437 1663-1674 Species denotes respiratory Tax:12814
2438 1213-1222 Chemical denotes quercetin MESH:D011794
2439 1236-1254 Chemical denotes penta-hydroxylated
2440 1255-1264 Chemical denotes flavonoid MESH:D005419
2441 1288-1299 Chemical denotes resveratrol MESH:D000077185
2442 1301-1310 Chemical denotes quercetin MESH:D011794
2443 1334-1340 Chemical denotes oxygen MESH:D010100
2444 1402-1411 Chemical denotes Quercetin MESH:D011794
2445 1451-1456 Chemical denotes lipid MESH:D008055
2446 1534-1543 Chemical denotes quercetin MESH:D011794
2447 1635-1644 Chemical denotes quercetin MESH:D011794
2448 1823-1832 Chemical denotes Quercetin MESH:D011794
2449 1990-1999 Chemical denotes quercetin MESH:D011794
2450 2096-2105 Chemical denotes quercetin MESH:D011794
2451 2245-2255 Chemical denotes flavonoids MESH:D005419
2452 2350-2359 Chemical denotes quercetin MESH:D011794
2453 2508-2517 Chemical denotes vitamin C MESH:D001205
2454 1426-1446 Disease denotes platelet aggregation MESH:D001791
2455 2421-2429 Disease denotes COVID-19 MESH:C000657245