PMC:7600245 / 71493-73243
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T307 | 309-313 | Body_part | denotes | back | http://purl.org/sig/ont/fma/fma25056 |
| T308 | 538-543 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T309 | 571-577 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T310 | 672-675 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T311 | 683-688 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
| T312 | 842-848 | Body_part | denotes | plasma | http://purl.org/sig/ont/fma/fma62970 |
| T313 | 856-864 | Body_part | denotes | platelet | http://purl.org/sig/ont/fma/fma62851 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T38 | 538-543 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
| T39 | 683-688 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T336 | 169-186 | Disease | denotes | methemoglobinemia | http://purl.obolibrary.org/obo/MONDO_0001117 |
| T337 | 523-531 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T338 | 656-664 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T339 | 889-897 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T340 | 909-914 | Disease | denotes | Ebola | http://purl.obolibrary.org/obo/MONDO_0005737 |
| T341 | 922-953 | Disease | denotes | Crimean-Congo hemorrhagic fever | http://purl.obolibrary.org/obo/MONDO_0020501 |
| T342 | 1621-1629 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T732 | 263-264 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T733 | 361-364 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T734 | 375-383 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T735 | 411-412 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T736 | 538-543 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T737 | 538-543 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T738 | 571-577 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T739 | 683-688 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
| T740 | 683-688 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
| T741 | 830-837 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T742 | 842-848 | http://purl.obolibrary.org/obo/UBERON_0001969 | denotes | plasma |
| T743 | 915-920 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T744 | 954-959 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T745 | 971-976 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T746 | 988-989 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T747 | 1102-1107 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | Virus |
| T748 | 1195-1196 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T749 | 1262-1270 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T750 | 1262-1270 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T751 | 1379-1387 | http://purl.obolibrary.org/obo/UBERON_0001637 | denotes | arterial |
| T752 | 1379-1387 | http://www.ebi.ac.uk/efo/EFO_0000814 | denotes | arterial |
| T753 | 1550-1560 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T754 | 1596-1602 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T755 | 1633-1634 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T265 | 34-48 | Chemical | denotes | Methylene blue | http://purl.obolibrary.org/obo/CHEBI_6872 |
| T96808 | 66-79 | Chemical | denotes | phenothiazine | http://purl.obolibrary.org/obo/CHEBI_37931|http://purl.obolibrary.org/obo/CHEBI_37932 |
| T89685 | 265-279 | Chemical | denotes | reducing agent | http://purl.obolibrary.org/obo/CHEBI_63247 |
| T48085 | 305-308 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T270 | 329-332 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T271 | 346-360 | Chemical | denotes | Methylene blue | http://purl.obolibrary.org/obo/CHEBI_6872 |
| T6002 | 365-374 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T9440 | 482-496 | Chemical | denotes | methylene blue | http://purl.obolibrary.org/obo/CHEBI_6872 |
| T72350 | 482-491 | Chemical | denotes | methylene | http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728 |
| T87870 | 593-607 | Chemical | denotes | Methylene blue | http://purl.obolibrary.org/obo/CHEBI_6872 |
| T43682 | 746-760 | Chemical | denotes | Methylene blue | http://purl.obolibrary.org/obo/CHEBI_6872 |
| T49062 | 1040-1054 | Chemical | denotes | methylene blue | http://purl.obolibrary.org/obo/CHEBI_6872 |
| T21560 | 1040-1049 | Chemical | denotes | methylene | http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728 |
| T42688 | 1177-1191 | Chemical | denotes | methylene blue | http://purl.obolibrary.org/obo/CHEBI_6872 |
| T27137 | 1177-1186 | Chemical | denotes | methylene | http://purl.obolibrary.org/obo/CHEBI_29357|http://purl.obolibrary.org/obo/CHEBI_29358|http://purl.obolibrary.org/obo/CHEBI_50728 |
| T64293 | 1204-1213 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T82162 | 1572-1576 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T7126 | 1697-1706 | Chemical | denotes | vitamin C | http://purl.obolibrary.org/obo/CHEBI_21241 |
| T88414 | 1697-1704 | Chemical | denotes | vitamin | http://purl.obolibrary.org/obo/CHEBI_33229 |
| T2973 | 1711-1727 | Chemical | denotes | N-acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_28939 |
| T15455 | 1713-1727 | Chemical | denotes | acetylcysteine | http://purl.obolibrary.org/obo/CHEBI_22198 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T141 | 1523-1560 | http://purl.obolibrary.org/obo/GO_1900226 | denotes | inhibit NLRP3 inflammasome activation |
| T142 | 1531-1560 | http://purl.obolibrary.org/obo/GO_0044546 | denotes | NLRP3 inflammasome activation |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T91 | 169-186 | Phenotype | denotes | methemoglobinemia | http://purl.obolibrary.org/obo/HP_0012119 |
| T92 | 948-953 | Phenotype | denotes | fever | http://purl.obolibrary.org/obo/HP_0001945 |
| T93 | 1151-1156 | Phenotype | denotes | shock | http://purl.obolibrary.org/obo/HP_0031273 |
| T94 | 1311-1316 | Phenotype | denotes | shock | http://purl.obolibrary.org/obo/HP_0031273 |
| T95 | 1448-1453 | Phenotype | denotes | shock | http://purl.obolibrary.org/obo/HP_0031273 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T556 | 0-5 | Sentence | denotes | 4.19. |
| T557 | 6-33 | Sentence | denotes | Methylene Blue (ProvayBlue) |
| T558 | 34-132 | Sentence | denotes | Methylene blue is disubstituted phenothiazine derivative (Figure S6) that was approved by the U.S. |
| T559 | 133-187 | Sentence | denotes | FDA for the parenteral treatment of methemoglobinemia. |
| T560 | 188-247 | Sentence | denotes | It acts by forming leukomethylene blue complex within RBCs. |
| T561 | 248-345 | Sentence | denotes | The product is a reducing agent that converts the ferric ion back to the ferrous ion state [256]. |
| T562 | 346-410 | Sentence | denotes | Methylene blue has antiviral activity [257,258,259,260,261,262]. |
| T563 | 411-592 | Sentence | denotes | A recent study showed that photochemical treatment in conjunction with methylene blue can be used to inactivate SARS-CoV-2 for blood safety and in convalescent plasma therapy [257]. |
| T564 | 593-745 | Sentence | denotes | Methylene blue is also known to kill coronavirus (specifically SARS-CoV-2) and HIV in the blood supply when combined with photo-biomodulation [258,259]. |
| T565 | 746-987 | Sentence | denotes | Methylene blue and UV/visible light have also been reported to inactivate different viruses, in plasma and in platelet concentrates, including SARS-CoV, MERS-CoV, Ebola virus, Crimean-Congo hemorrhagic fever virus, and Nipah virus [260,261]. |
| T566 | 988-1114 | Sentence | denotes | A mice model study also demonstrated the ability of methylene blue plus fluorescent light to inactivate West Nile Virus [262]. |
| T567 | 1115-1163 | Sentence | denotes | It is also effective against septic shock [263]. |
| T568 | 1164-1323 | Sentence | denotes | Furthermore, methylene blue is a potent inhibitor of guanylate cyclase, and thus, it improves the arterial pressure and cardiac function in septic shock [264]. |
| T569 | 1324-1460 | Sentence | denotes | It also improves systemic vascular resistance and mean arterial pressure while decreases vasopressor requirements in septic shock [265]. |
| T570 | 1461-1567 | Sentence | denotes | It also demonstrates anti-inflammatory effects because it can inhibit NLRP3 inflammasome activation [266]. |
| T571 | 1568-1750 | Sentence | denotes | The drug is currently being tested in the context of COVID-19 in a few trials alone (NCT04376788; n = 15) or in combination with vitamin C and N-acetylcysteine (NCT04370288; n = 20). |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2206 | 6-20 | Chemical | denotes | Methylene Blue | MESH:D008751 |
| 2207 | 22-32 | Chemical | denotes | ProvayBlue | MESH:D008751 |
| 2237 | 1531-1536 | Gene | denotes | NLRP3 | Gene:114548 |
| 2238 | 523-533 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2239 | 630-641 | Species | denotes | coronavirus | Tax:11118 |
| 2240 | 656-666 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 2241 | 889-897 | Species | denotes | SARS-CoV | Tax:694009 |
| 2242 | 899-907 | Species | denotes | MERS-CoV | Tax:1335626 |
| 2243 | 909-920 | Species | denotes | Ebola virus | Tax:1570291 |
| 2244 | 922-959 | Species | denotes | Crimean-Congo hemorrhagic fever virus | Tax:11593 |
| 2245 | 965-976 | Species | denotes | Nipah virus | Tax:121791 |
| 2246 | 990-994 | Species | denotes | mice | Tax:10090 |
| 2247 | 1092-1107 | Species | denotes | West Nile Virus | Tax:11082 |
| 2248 | 34-48 | Chemical | denotes | Methylene blue | MESH:D008751 |
| 2249 | 66-79 | Chemical | denotes | phenothiazine | MESH:C031637 |
| 2250 | 207-226 | Chemical | denotes | leukomethylene blue | MESH:C011010 |
| 2251 | 298-308 | Chemical | denotes | ferric ion | MESH:D007501 |
| 2252 | 321-332 | Chemical | denotes | ferrous ion | |
| 2253 | 346-360 | Chemical | denotes | Methylene blue | MESH:D008751 |
| 2254 | 482-496 | Chemical | denotes | methylene blue | MESH:D008751 |
| 2255 | 593-607 | Chemical | denotes | Methylene blue | MESH:D008751 |
| 2256 | 746-760 | Chemical | denotes | Methylene blue | MESH:D008751 |
| 2257 | 1040-1054 | Chemical | denotes | methylene blue | MESH:D008751 |
| 2258 | 1177-1191 | Chemical | denotes | methylene blue | MESH:D008751 |
| 2259 | 1697-1706 | Chemical | denotes | vitamin C | MESH:D001205 |
| 2260 | 1711-1727 | Chemical | denotes | N-acetylcysteine | |
| 2261 | 169-186 | Disease | denotes | methemoglobinemia | MESH:D008708 |
| 2262 | 1144-1156 | Disease | denotes | septic shock | MESH:D012772 |
| 2263 | 1304-1316 | Disease | denotes | septic shock | MESH:D012772 |
| 2264 | 1441-1453 | Disease | denotes | septic shock | MESH:D012772 |
| 2265 | 1621-1629 | Disease | denotes | COVID-19 | MESH:C000657245 |