PMC:7600245 / 64583-65549
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T279 | 663-667 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T280 | 668-678 | Body_part | denotes | lymphocyte | http://purl.org/sig/ont/fma/fma62863 |
| T281 | 692-702 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
| T282 | 784-794 | Body_part | denotes | neutrophil | http://purl.org/sig/ont/fma/fma62860 |
| T283 | 819-833 | Body_part | denotes | dendritic cell | http://purl.org/sig/ont/fma/fma273565 |
| T284 | 829-833 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T285 | 891-910 | Body_part | denotes | alveolar macrophage | http://purl.org/sig/ont/fma/fma83023 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T308 | 478-486 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T652 | 0-1 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T653 | 32-35 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T654 | 124-125 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T655 | 266-271 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T656 | 311-314 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T657 | 538-541 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T658 | 661-667 | http://purl.obolibrary.org/obo/CL_0000084 | denotes | T-cell |
| T659 | 718-721 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T660 | 819-833 | http://purl.obolibrary.org/obo/CL_0000451 | denotes | dendritic cell |
| T661 | 938-943 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T38126 | 51-61 | Chemical | denotes | levamisole | http://purl.obolibrary.org/obo/CHEBI_6432 |
| T19308 | 370-380 | Chemical | denotes | levamisole | http://purl.obolibrary.org/obo/CHEBI_6432 |
| T72066 | 427-437 | Chemical | denotes | budesonide | http://purl.obolibrary.org/obo/CHEBI_3207 |
| T64107 | 438-448 | Chemical | denotes | formoterol | http://purl.obolibrary.org/obo/CHEBI_5147 |
| T70057 | 869-879 | Chemical | denotes | levamisole | http://purl.obolibrary.org/obo/CHEBI_6432 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T128 | 692-713 | http://purl.obolibrary.org/obo/GO_0048246 | denotes | macrophage chemotaxis |
| T129 | 703-713 | http://purl.obolibrary.org/obo/GO_0006935 | denotes | chemotaxis |
| T130 | 784-805 | http://purl.obolibrary.org/obo/GO_0030593 | denotes | neutrophil chemotaxis |
| T131 | 795-805 | http://purl.obolibrary.org/obo/GO_0006935 | denotes | chemotaxis |
| T132 | 829-844 | http://purl.obolibrary.org/obo/GO_0048469 | denotes | cell maturation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T499 | 0-278 | Sentence | denotes | A recent computational exercise has suggested that levamisole potentially binds to the catalytic domain of the viral PLpro, a viral enzyme that processes the newly biosynthesized viral polyproteins and eventually contributes to the maturation and infectivity of the virus [228]. |
| T500 | 279-338 | Sentence | denotes | Yet, no experimental validation has been reported thus far. |
| T501 | 339-510 | Sentence | denotes | As of now, orally administered levamisole is being studied alone or in combination with budesonide/formoterol inhaler for the treatment of COVID-19 in few clinical trials. |
| T502 | 511-587 | Sentence | denotes | The rationale for this use has been because of its immunomodulatory effects. |
| T503 | 588-714 | Sentence | denotes | Levamisole acts as an immune-modulator and immune-enhancer by increasing T-cell lymphocyte function and macrophage chemotaxis. |
| T504 | 715-855 | Sentence | denotes | It has also been shown to up-regulate toll-like receptors, stimulate neutrophil chemotaxis, and enhance dendritic cell maturation [229,230]. |
| T505 | 856-966 | Sentence | denotes | Furthermore, levamisole attenuated alveolar macrophage dysfunction in respiratory virus-infected calves [231]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 2035 | 117-122 | Gene | denotes | PLpro | Gene:43740578 |
| 2036 | 953-959 | Species | denotes | calves | Tax:9913 |
| 2037 | 51-61 | Chemical | denotes | levamisole | MESH:D007978 |
| 2038 | 370-380 | Chemical | denotes | levamisole | MESH:D007978 |
| 2039 | 427-437 | Chemical | denotes | budesonide | MESH:D019819 |
| 2040 | 438-448 | Chemical | denotes | formoterol | MESH:D000068759 |
| 2041 | 588-598 | Chemical | denotes | Levamisole | MESH:D007978 |
| 2042 | 869-879 | Chemical | denotes | levamisole | MESH:D007978 |
| 2043 | 478-486 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 2044 | 880-922 | Disease | denotes | attenuated alveolar macrophage dysfunction | MESH:C538265 |
| 2045 | 926-952 | Disease | denotes | respiratory virus-infected |