PMC:7600245 / 60946-62893
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T269 | 351-356 | Body_part | denotes | urine | http://purl.org/sig/ont/fma/fma12274 |
| T270 | 407-412 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T271 | 521-526 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T272 | 617-622 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
| T273 | 1185-1188 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T274 | 1210-1213 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T275 | 1509-1513 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T276 | 1551-1559 | Body_part | denotes | antibody | http://purl.org/sig/ont/fma/fma62871 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T25 | 351-356 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
| T26 | 407-412 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T27 | 521-526 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
| T28 | 617-622 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T280 | 425-433 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T281 | 539-547 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T282 | 576-584 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T283 | 778-794 | Disease | denotes | viral infections | http://purl.obolibrary.org/obo/MONDO_0005108 |
| T284 | 843-861 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T285 | 866-901 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T286 | 872-901 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T287 | 1009-1017 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T288 | 1639-1651 | Disease | denotes | inflammation | http://purl.obolibrary.org/obo/MONDO_0021166 |
| T289 | 1663-1672 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T290 | 1675-1684 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T291 | 1836-1854 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
| T292 | 1909-1927 | Disease | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/MONDO_0002771 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T628 | 51-53 | http://purl.obolibrary.org/obo/CLO_0008933 | denotes | S5 |
| T629 | 58-59 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T630 | 161-164 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T631 | 444-447 | http://purl.obolibrary.org/obo/CLO_0001180 | denotes | 203 |
| T632 | 450-451 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T633 | 1018-1021 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T634 | 1124-1127 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T635 | 1147-1148 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T636 | 1189-1196 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T637 | 1229-1234 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T638 | 1507-1513 | http://purl.obolibrary.org/obo/CL_0000236 | denotes | B cell |
| T639 | 1586-1589 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T640 | 1673-1674 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T641 | 1928-1934 | http://purl.obolibrary.org/obo/NCBITaxon_33208 | denotes | animal |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T77814 | 20-28 | Chemical | denotes | Desferal | http://purl.obolibrary.org/obo/CHEBI_31460 |
| T4002 | 51-53 | Chemical | denotes | S5 | http://purl.obolibrary.org/obo/CHEBI_29386 |
| T55903 | 197-201 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T47918 | 216-220 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T67695 | 247-250 | Chemical | denotes | ion | http://purl.obolibrary.org/obo/CHEBI_24870 |
| T88245 | 293-305 | Chemical | denotes | ferrioxamine | http://purl.obolibrary.org/obo/CHEBI_26672 |
| T72674 | 655-659 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T50966 | 743-747 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T9205 | 945-959 | Chemical | denotes | iron chelators | http://purl.obolibrary.org/obo/CHEBI_38157 |
| T89780 | 945-949 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T68757 | 950-959 | Chemical | denotes | chelators | http://purl.obolibrary.org/obo/CHEBI_38161 |
| T62283 | 974-986 | Chemical | denotes | deferoxamine | http://purl.obolibrary.org/obo/CHEBI_4356 |
| T69571 | 1069-1078 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T27751 | 1099-1103 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T37926 | 1287-1291 | Chemical | denotes | iron | http://purl.obolibrary.org/obo/CHEBI_18248 |
| T16477 | 1299-1311 | Chemical | denotes | deferoxamine | http://purl.obolibrary.org/obo/CHEBI_4356 |
| T72794 | 1384-1396 | Chemical | denotes | deferoxamine | http://purl.obolibrary.org/obo/CHEBI_4356 |
| T91637 | 1699-1701 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T161 | 1799-1811 | Chemical | denotes | deferoxamine | http://purl.obolibrary.org/obo/CHEBI_4356 |
| T89529 | 1891-1900 | Chemical | denotes | bleomycin | http://purl.obolibrary.org/obo/CHEBI_22907 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T115 | 655-671 | http://purl.obolibrary.org/obo/GO_0055072 | denotes | iron homeostasis |
| T116 | 655-671 | http://purl.obolibrary.org/obo/GO_0006879 | denotes | iron homeostasis |
| T117 | 660-671 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T118 | 707-728 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory response |
| T119 | 743-759 | http://purl.obolibrary.org/obo/GO_0055072 | denotes | iron homeostasis |
| T120 | 743-759 | http://purl.obolibrary.org/obo/GO_0006879 | denotes | iron homeostasis |
| T121 | 748-759 | http://purl.obolibrary.org/obo/GO_0042592 | denotes | homeostasis |
| T122 | 778-794 | http://purl.obolibrary.org/obo/GO_0016032 | denotes | viral infections |
| T123 | 1639-1651 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammation |
| T124 | 1704-1713 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T71 | 605-631 | Phenotype | denotes | increase in serum ferritin | http://purl.obolibrary.org/obo/HP_0003281 |
| T72 | 686-702 | Phenotype | denotes | oxidative stress | http://purl.obolibrary.org/obo/HP_0025464 |
| T73 | 813-834 | Phenotype | denotes | respiratory illnesses | http://purl.obolibrary.org/obo/HP_0002086 |
| T74 | 843-861 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T75 | 872-892 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
| T76 | 1836-1854 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
| T77 | 1909-1927 | Phenotype | denotes | pulmonary fibrosis | http://purl.obolibrary.org/obo/HP_0002206 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T462 | 0-5 | Sentence | denotes | 4.11. |
| T463 | 6-29 | Sentence | denotes | Deferoxamine (Desferal) |
| T464 | 30-110 | Sentence | denotes | Deferoxamine (Figure S5) is a natural chelating agent from Streptomyces pilosus. |
| T465 | 111-144 | Sentence | denotes | It was first approved by the U.S. |
| T466 | 145-211 | Sentence | denotes | FDA in 1968 and has been parenterally used to treat iron toxicity. |
| T467 | 212-367 | Sentence | denotes | The drug complexes with the ferric ion, primarily in the vascular space, to form ferrioxamine complex that gets subsequently eliminated in urine [201,202]. |
| T468 | 368-449 | Sentence | denotes | There are reports about unusually high serum ferritin in COVID-19 patients [203]. |
| T469 | 450-600 | Sentence | denotes | A retrospective, multicenter cohort study reported increased levels of serum ferritin in COVID-19 non-survivors compared with COVID-19 survivors [99]. |
| T470 | 601-729 | Sentence | denotes | The increase in serum ferritin indicates dysregulated iron homeostasis pertaining to oxidative stress and inflammatory response. |
| T471 | 730-920 | Sentence | denotes | Dysregulated iron homeostasis may propagate the viral infections leading to severe respiratory illnesses such as pulmonary fibrosis and acute respiratory distress syndrome [204,205,206,207]. |
| T472 | 921-1042 | Sentence | denotes | Accordingly, the use of iron chelators, particularly deferoxamine, in managing/treating COVID-19 has been proposed [208]. |
| T473 | 1043-1257 | Sentence | denotes | Deferoxamine may exert an antiviral effect by depleting iron availability, which has been shown to play a critical role in the replication of RNA viruses such as HCV, HIV, and West Nile virus [209,210,211,212,213]. |
| T474 | 1258-1364 | Sentence | denotes | In addition to its effect on iron level, deferoxamine also appears to have immunomodulatory effects [209]. |
| T475 | 1365-1482 | Sentence | denotes | Along these lines, deferoxamine mitigated the symptoms of Enterovirus-infected mice and decreased the mortality rate. |
| T476 | 1483-1572 | Sentence | denotes | It also upregulated the B cell levels and improved the neutralizing antibody titer [209]. |
| T477 | 1573-1720 | Sentence | denotes | Deferoxamine has also been reported to in vitro block endothelial inflammation induced by influenza A infection by inhibiting IL-6 synthesis [214]. |
| T478 | 1721-1769 | Sentence | denotes | Deferoxamine may also have antifibrotic effects. |
| T479 | 1770-1947 | Sentence | denotes | An intranasal treatment with deferoxamine was reported to prevent pulmonary fibrosis and pulmonary functional decline in bleomycin-induced pulmonary fibrosis animal model [206]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1892 | 6-18 | Chemical | denotes | Deferoxamine | MESH:D003676 |
| 1893 | 20-28 | Chemical | denotes | Desferal | MESH:D003676 |
| 1900 | 89-109 | Species | denotes | Streptomyces pilosus | Tax:28893 |
| 1901 | 30-42 | Chemical | denotes | Deferoxamine | MESH:D003676 |
| 1902 | 197-201 | Chemical | denotes | iron | MESH:D007501 |
| 1903 | 240-250 | Chemical | denotes | ferric ion | MESH:D007501 |
| 1904 | 293-305 | Chemical | denotes | ferrioxamine | MESH:C002577 |
| 1905 | 202-210 | Disease | denotes | toxicity | MESH:D064420 |
| 1939 | 1699-1703 | Gene | denotes | IL-6 | Gene:3569 |
| 1940 | 434-442 | Species | denotes | patients | Tax:9606 |
| 1941 | 1219-1234 | Species | denotes | West Nile virus | Tax:11082 |
| 1942 | 1444-1448 | Species | denotes | mice | Tax:10090 |
| 1943 | 1663-1672 | Species | denotes | influenza | Tax:11520 |
| 1944 | 655-659 | Chemical | denotes | iron | MESH:D007501 |
| 1945 | 743-747 | Chemical | denotes | iron | MESH:D007501 |
| 1946 | 945-949 | Chemical | denotes | iron | MESH:D007501 |
| 1947 | 974-986 | Chemical | denotes | deferoxamine | MESH:D003676 |
| 1948 | 1043-1055 | Chemical | denotes | Deferoxamine | MESH:D003676 |
| 1949 | 1099-1103 | Chemical | denotes | iron | MESH:D007501 |
| 1950 | 1287-1291 | Chemical | denotes | iron | MESH:D007501 |
| 1951 | 1299-1311 | Chemical | denotes | deferoxamine | MESH:D003676 |
| 1952 | 1384-1396 | Chemical | denotes | deferoxamine | MESH:D003676 |
| 1953 | 1573-1585 | Chemical | denotes | Deferoxamine | MESH:D003676 |
| 1954 | 1721-1733 | Chemical | denotes | Deferoxamine | MESH:D003676 |
| 1955 | 1799-1811 | Chemical | denotes | deferoxamine | MESH:D003676 |
| 1956 | 1891-1900 | Chemical | denotes | bleomycin | MESH:D001761 |
| 1957 | 425-433 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1958 | 539-547 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1959 | 576-584 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1960 | 778-794 | Disease | denotes | viral infections | MESH:D001102 |
| 1961 | 813-834 | Disease | denotes | respiratory illnesses | MESH:D012140 |
| 1962 | 843-861 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 1963 | 866-901 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 1964 | 1009-1017 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1965 | 1423-1443 | Disease | denotes | Enterovirus-infected | MESH:D004769 |
| 1966 | 1467-1476 | Disease | denotes | mortality | MESH:D003643 |
| 1967 | 1639-1651 | Disease | denotes | inflammation | MESH:D007249 |
| 1968 | 1673-1684 | Disease | denotes | A infection | MESH:D007239 |
| 1969 | 1836-1854 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |
| 1970 | 1859-1887 | Disease | denotes | pulmonary functional decline | MESH:D003072 |
| 1971 | 1909-1927 | Disease | denotes | pulmonary fibrosis | MESH:D011658 |