PMC:7600245 / 59620-60944
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T261 | 174-178 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T262 | 226-230 | Body_part | denotes | gene | http://purl.org/sig/ont/fma/fma74402 |
| T263 | 322-325 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T264 | 330-337 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T265 | 648-651 | Body_part | denotes | HIV | http://purl.org/sig/ont/fma/fma278683 |
| T266 | 846-854 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T267 | 884-887 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T268 | 964-968 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T24 | 964-968 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T263 | 111-119 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T264 | 155-164 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T265 | 313-321 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T266 | 435-450 | Disease | denotes | gastroenteritis | http://purl.obolibrary.org/obo/MONDO_0002269 |
| T267 | 481-489 | Disease | denotes | diarrhea | http://purl.obolibrary.org/obo/MONDO_0001673 |
| T268 | 706-710 | Disease | denotes | Zika | http://purl.obolibrary.org/obo/MONDO_0018661 |
| T269 | 735-752 | Disease | denotes | Rift Valley fever | http://purl.obolibrary.org/obo/MONDO_0017880 |
| T270 | 740-752 | Disease | denotes | Valley fever | http://purl.obolibrary.org/obo/MONDO_0005706 |
| T271 | 764-773 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T272 | 958-975 | Disease | denotes | acute lung injury | http://purl.obolibrary.org/obo/MONDO_0006502|http://purl.obolibrary.org/obo/MONDO_0015796 |
| T274 | 969-975 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T275 | 1061-1069 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T276 | 1106-1114 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T277 | 1192-1200 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T278 | 1221-1241 | Disease | denotes | keratoconjunctivitis | http://purl.obolibrary.org/obo/MONDO_0004768 |
| T279 | 1300-1308 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T605 | 58-59 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T606 | 62-64 | http://purl.obolibrary.org/obo/CLO_0001000 | denotes | 35 |
| T607 | 121-126 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T608 | 149-154 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T609 | 165-170 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T610 | 174-178 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T611 | 200-201 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T612 | 226-230 | http://purl.obolibrary.org/obo/OGG_0000000002 | denotes | gene |
| T613 | 282-283 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T614 | 368-369 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T615 | 490-495 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T616 | 549-550 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T617 | 551-554 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T618 | 711-716 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T619 | 728-733 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T620 | 753-758 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T621 | 774-775 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T622 | 776-781 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T623 | 964-968 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T624 | 964-968 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T625 | 1017-1018 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
| T626 | 1028-1034 | http://purl.obolibrary.org/obo/UBERON_0000473 | denotes | tested |
| T627 | 1268-1271 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T18965 | 46-59 | Chemical | denotes | cyclosporin A | http://purl.obolibrary.org/obo/CHEBI_4031 |
| T74294 | 188-201 | Chemical | denotes | Cyclosporin A | http://purl.obolibrary.org/obo/CHEBI_4031 |
| T29939 | 270-283 | Chemical | denotes | Cyclosporin A | http://purl.obolibrary.org/obo/CHEBI_4031 |
| T23807 | 330-337 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T54744 | 355-367 | Chemical | denotes | Cyclosporine | http://purl.obolibrary.org/obo/CHEBI_4031 |
| T56147 | 583-592 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T13437 | 659-671 | Chemical | denotes | Cyclosporine | http://purl.obolibrary.org/obo/CHEBI_4031 |
| T2870 | 846-854 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T60058 | 936-940 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T24343 | 1005-1018 | Chemical | denotes | cyclosporin A | http://purl.obolibrary.org/obo/CHEBI_4031 |
| T39022 | 1174-1188 | Chemical | denotes | corticosteroid | http://purl.obolibrary.org/obo/CHEBI_50858 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T109 | 226-241 | http://purl.obolibrary.org/obo/GO_0010467 | denotes | gene expression |
| T110 | 330-347 | http://purl.obolibrary.org/obo/GO_0006412 | denotes | protein synthesis |
| T111 | 338-347 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T112 | 869-897 | http://purl.obolibrary.org/obo/GO_1902679 | denotes | inhibiting the RNA synthesis |
| T113 | 884-897 | http://purl.obolibrary.org/obo/GO_0032774 | denotes | RNA synthesis |
| T114 | 888-897 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T66 | 155-164 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T67 | 481-489 | Phenotype | denotes | diarrhea | http://purl.obolibrary.org/obo/HP_0002014 |
| T68 | 740-752 | Phenotype | denotes | Valley fever | http://purl.obolibrary.org/obo/HP_0032249 |
| T69 | 958-975 | Phenotype | denotes | acute lung injury | http://www.orpha.net/ORDO/Orphanet_178320 |
| T70 | 1221-1241 | Phenotype | denotes | keratoconjunctivitis | http://purl.obolibrary.org/obo/HP_0001096 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T452 | 0-187 | Sentence | denotes | Importantly, low micromolar concentrations of cyclosporin A (<35 µM) substantially impacted the replication of SARS-CoV, human coronavirus 229E, and mouse hepatitis virus in cell culture. |
| T453 | 188-269 | Sentence | denotes | Cyclosporin A significantly inhibited gene expression and reduced progeny titers. |
| T454 | 270-354 | Sentence | denotes | Cyclosporin A treatment completely blocked SARS-CoV RNA and protein synthesis [196]. |
| T455 | 355-526 | Sentence | denotes | Cyclosporine A also in vitro reduced the replication of MERS-CoV, transmissible gastroenteritis coronavirus, porcine epidemic diarrhea virus, and feline coronavirus [196]. |
| T456 | 527-601 | Sentence | denotes | In fact, cyclosporine A has demonstrated broad-spectrum antiviral effects. |
| T457 | 602-658 | Sentence | denotes | It inhibited the replication of HBV, HCV, and HIV [197]. |
| T458 | 659-904 | Sentence | denotes | Cyclosporine also inhibited the replication of Zika virus, West Nile virus, Rift Valley fever virus, and influenza A virus by blocking the interaction of cellular cyclophilins with viral proteins as well as by inhibiting the RNA synthesis [198]. |
| T459 | 905-982 | Sentence | denotes | By targeting cyclophilins, the drug can also prevent acute lung injury [199]. |
| T460 | 983-1264 | Sentence | denotes | Currently, the use of cyclosporin A is being tested in patients with moderate COVID-19 (NCT04412785; n = 20), hospitalized COVID-19 patients (NCT04392531; n = 120), and combined with topical corticosteroid in COVID-19 patients with acute keratoconjunctivitis (NCT04451239; n = 12). |
| T461 | 1265-1324 | Sentence | denotes | It has also been used in psoriatic COVID-19 patients [200]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1861 | 111-119 | Species | denotes | SARS-CoV | Tax:694009 |
| 1862 | 121-143 | Species | denotes | human coronavirus 229E | Tax:11137 |
| 1863 | 149-170 | Species | denotes | mouse hepatitis virus | Tax:11138 |
| 1864 | 313-321 | Species | denotes | SARS-CoV | Tax:694009 |
| 1865 | 411-419 | Species | denotes | MERS-CoV | Tax:1335626 |
| 1866 | 421-462 | Species | denotes | transmissible gastroenteritis coronavirus | Tax:11149 |
| 1867 | 464-495 | Species | denotes | porcine epidemic diarrhea virus | Tax:28295 |
| 1868 | 501-519 | Species | denotes | feline coronavirus | Tax:12663 |
| 1869 | 706-716 | Species | denotes | Zika virus | Tax:64320 |
| 1870 | 718-733 | Species | denotes | West Nile virus | Tax:11082 |
| 1871 | 735-758 | Species | denotes | Rift Valley fever virus | Tax:11588 |
| 1872 | 764-781 | Species | denotes | influenza A virus | Tax:11320 |
| 1873 | 1038-1046 | Species | denotes | patients | Tax:9606 |
| 1874 | 1115-1123 | Species | denotes | patients | Tax:9606 |
| 1875 | 1201-1209 | Species | denotes | patients | Tax:9606 |
| 1876 | 1309-1317 | Species | denotes | patients | Tax:9606 |
| 1877 | 634-637 | Species | denotes | HBV | Tax:10407 |
| 1878 | 46-59 | Chemical | denotes | cyclosporin A | MESH:D016572 |
| 1879 | 270-283 | Chemical | denotes | Cyclosporin A | MESH:D016572 |
| 1880 | 355-369 | Chemical | denotes | Cyclosporine A | MESH:D016572 |
| 1881 | 536-550 | Chemical | denotes | cyclosporine A | MESH:D016572 |
| 1882 | 659-671 | Chemical | denotes | Cyclosporine | MESH:D016572 |
| 1883 | 1005-1018 | Chemical | denotes | cyclosporin A | MESH:D016572 |
| 1884 | 964-975 | Disease | denotes | lung injury | MESH:D055370 |
| 1885 | 1061-1069 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1886 | 1106-1114 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1887 | 1192-1200 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1888 | 1215-1241 | Disease | denotes | acute keratoconjunctivitis | MESH:D007637 |
| 1889 | 1300-1308 | Disease | denotes | COVID-19 | MESH:C000657245 |