PMC:7600245 / 54169-55109
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T237 | 78-89 | Body_part | denotes | microtubule | http://purl.org/sig/ont/fma/fma63849 |
| T238 | 156-163 | Body_part | denotes | tubulin | http://purl.org/sig/ont/fma/fma67116 |
| T239 | 247-259 | Body_part | denotes | microtubules | http://purl.org/sig/ont/fma/fma63849 |
| T240 | 379-391 | Body_part | denotes | microtubules | http://purl.org/sig/ont/fma/fma63849 |
| T241 | 443-454 | Body_part | denotes | Microtubule | http://purl.org/sig/ont/fma/fma63849 |
| T242 | 563-571 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T234 | 217-223 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T235 | 361-365 | Disease | denotes | SARS | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T236 | 432-441 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T237 | 589-597 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T238 | 600-609 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T239 | 726-734 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T240 | 769-804 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T241 | 775-804 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T242 | 916-924 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T546 | 177-180 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T547 | 281-289 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T548 | 342-349 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T549 | 415-422 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T550 | 658-659 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T551 | 888-891 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T25991 | 44-50 | Chemical | denotes | indole | http://purl.obolibrary.org/obo/CHEBI_16881|http://purl.obolibrary.org/obo/CHEBI_35581 |
| T52649 | 129-139 | Chemical | denotes | colchicine | http://purl.obolibrary.org/obo/CHEBI_23359 |
| T63794 | 271-280 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T63616 | 621-625 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T46440 | 870-880 | Chemical | denotes | colchicine | http://purl.obolibrary.org/obo/CHEBI_23359 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T87 | 78-106 | http://purl.obolibrary.org/obo/GO_0007019 | denotes | microtubule depolymerization |
| T88 | 315-349 | http://purl.obolibrary.org/obo/GO_0075733 | denotes | intracellular transport of viruses |
| T89 | 315-338 | http://purl.obolibrary.org/obo/GO_0046907 | denotes | intracellular transport |
| T90 | 329-338 | http://purl.obolibrary.org/obo/GO_0006810 | denotes | transport |
| T91 | 443-471 | http://purl.obolibrary.org/obo/GO_0007019 | denotes | Microtubule depolymerization |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T54 | 217-223 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T55 | 563-577 | Phenotype | denotes | cytokine storm | http://purl.obolibrary.org/obo/HP_0033041 |
| T56 | 775-795 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T403 | 0-173 | Sentence | denotes | It is an orally bioavailable, 3-substituted indole derivative (Figure 8A) and microtubule depolymerization agent that recognizes colchicine-binding site on tubulin subunits. |
| T404 | 174-230 | Sentence | denotes | It has been under clinical development for cancer [170]. |
| T405 | 231-442 | Sentence | denotes | Drugs targeting microtubules have broad antiviral activity because they disrupt the intracellular transport of viruses, including SARS CoV-2, along microtubules, which is critical for viruses to cause infection. |
| T406 | 443-616 | Sentence | denotes | Microtubule depolymerization agents also have strong anti-inflammatory effects that can be beneficial in mitigating the cytokine storm induced by SARS-CoV-2 infection [171]. |
| T407 | 617-827 | Sentence | denotes | The drug is currently being evaluated in a phase 2 randomized, placebo-controlled study for the treatment of SARS-CoV-2 in patients at elevated risk of acute respiratory distress syndrome (NCT04388826; n = 40). |
| T408 | 828-940 | Sentence | denotes | Of note, it is mechanistically similar to colchicine, which has also been considered in COVID-19 patients [172]. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1686 | 361-371 | Species | denotes | SARS CoV-2 | Tax:2697049 |
| 1687 | 726-736 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1688 | 740-748 | Species | denotes | patients | Tax:9606 |
| 1689 | 925-933 | Species | denotes | patients | Tax:9606 |
| 1690 | 31-50 | Chemical | denotes | -substituted indole | |
| 1691 | 129-139 | Chemical | denotes | colchicine | MESH:D003078 |
| 1692 | 870-880 | Chemical | denotes | colchicine | MESH:D003078 |
| 1693 | 217-223 | Disease | denotes | cancer | MESH:D009369 |
| 1694 | 432-441 | Disease | denotes | infection | MESH:D007239 |
| 1695 | 589-609 | Disease | denotes | SARS-CoV-2 infection | MESH:C000657245 |
| 1696 | 769-804 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 1697 | 916-924 | Disease | denotes | COVID-19 | MESH:C000657245 |