PMC:7600245 / 52738-54153
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T236 | 1110-1113 | Body_part | denotes | arm | http://purl.org/sig/ont/fma/fma24890 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T20 | 1110-1113 | Body_part | denotes | arm | http://purl.obolibrary.org/obo/UBERON_0001460 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T229 | 251-282 | Disease | denotes | gastroesophageal reflux disease | http://purl.obolibrary.org/obo/MONDO_0007186 |
| T230 | 299-311 | Disease | denotes | peptic ulcer | http://purl.obolibrary.org/obo/MONDO_0004247 |
| T231 | 306-311 | Disease | denotes | ulcer | http://purl.obolibrary.org/obo/MONDO_0043839 |
| T232 | 555-563 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T233 | 631-639 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T534 | 14-15 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T535 | 79-80 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T536 | 329-330 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T537 | 602-603 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T538 | 691-692 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T539 | 772-773 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T540 | 784-786 | http://purl.obolibrary.org/obo/CLO_0053733 | denotes | 11 |
| T541 | 996-999 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T542 | 1064-1065 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T543 | 1110-1113 | http://www.ebi.ac.uk/efo/EFO_0001410 | denotes | arm |
| T544 | 1235-1238 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T545 | 1325-1326 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T2013 | 35-43 | Chemical | denotes | thiazole | http://purl.obolibrary.org/obo/CHEBI_43732|http://purl.obolibrary.org/obo/CHEBI_48901 |
| T78712 | 104-106 | Chemical | denotes | H2 | http://purl.obolibrary.org/obo/CHEBI_18276 |
| T92725 | 198-202 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T27956 | 455-465 | Chemical | denotes | famotidine | http://purl.obolibrary.org/obo/CHEBI_4975 |
| T55138 | 475-497 | Chemical | denotes | proton pump inhibitors | http://purl.obolibrary.org/obo/CHEBI_49200 |
| T68332 | 475-481 | Chemical | denotes | proton | http://purl.obolibrary.org/obo/CHEBI_24636 |
| T72811 | 487-497 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T96455 | 711-721 | Chemical | denotes | famotidine | http://purl.obolibrary.org/obo/CHEBI_4975 |
| T73357 | 863-873 | Chemical | denotes | famotidine | http://purl.obolibrary.org/obo/CHEBI_4975 |
| T69341 | 919-929 | Chemical | denotes | famotidine | http://purl.obolibrary.org/obo/CHEBI_4975 |
| T6716 | 973-991 | Chemical | denotes | hydroxychloroquine | http://purl.obolibrary.org/obo/CHEBI_5801 |
| T50648 | 1022-1032 | Chemical | denotes | remdesivir | http://purl.obolibrary.org/obo/CHEBI_145994 |
| T31143 | 1337-1346 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T51 | 251-282 | Phenotype | denotes | gastroesophageal reflux disease | http://purl.obolibrary.org/obo/HP_0002020 |
| T52 | 284-293 | Phenotype | denotes | heartburn | http://purl.obolibrary.org/obo/HP_0002020 |
| T53 | 299-311 | Phenotype | denotes | peptic ulcer | http://purl.obolibrary.org/obo/HP_0004398 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T393 | 0-115 | Sentence | denotes | Famotidine is a synthetic guandino-thiazole derivative (Figure 7) that acts as a potent and competitive H2-blocker. |
| T394 | 116-149 | Sentence | denotes | It was first approved by the U.S. |
| T395 | 150-203 | Sentence | denotes | FDA in 1986 and now is used as over-the-counter drug. |
| T396 | 204-318 | Sentence | denotes | It can be used orally or parenterally to treat gastroesophageal reflux disease, heartburn, and peptic ulcer [166]. |
| T397 | 319-588 | Sentence | denotes | Recently, a retrospective non-randomized study by Columbia University, Northwell Health, and Massachusetts General Hospital showed that famotidine, and not proton pump inhibitors, reduced the risk of intubation or death in hospitalized COVID-19 patients (n = 84) [167]. |
| T398 | 589-880 | Sentence | denotes | Furthermore, a case series indicated that COVID-19 patients (n = 10) who frequently self-administered a high-dose of oral famotidine (most frequent dose was 80 mg three times/day for a median of 11 days) reported significant symptoms improvement within 24 hours of starting famotidine [168]. |
| T399 | 881-1223 | Sentence | denotes | Therefore, intravenously administered famotidine with standard of care (orally administered hydroxychloroquine and has progressed to include remdesivir) is currently being studied in a multi-site, randomized, double-blind, multi-arm historical control, comparative trial that is sponsored by Northwell Health, New York (NCT04370262; n = 942). |
| T400 | 1224-1415 | Sentence | denotes | Famotidine has been identified via virtual screening and molecular modeling, docking, and scoring as a potential inhibitor of Mpro [169], yet this potential is to be experimentally confirmed. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1656 | 1350-1354 | Gene | denotes | Mpro | Gene:8673700 |
| 1657 | 564-572 | Species | denotes | patients | Tax:9606 |
| 1658 | 640-648 | Species | denotes | patients | Tax:9606 |
| 1659 | 0-10 | Chemical | denotes | Famotidine | MESH:D015738 |
| 1660 | 26-43 | Chemical | denotes | guandino-thiazole | |
| 1661 | 104-106 | Chemical | denotes | H2 | MESH:D003903 |
| 1662 | 455-465 | Chemical | denotes | famotidine | MESH:D015738 |
| 1663 | 711-721 | Chemical | denotes | famotidine | MESH:D015738 |
| 1664 | 863-873 | Chemical | denotes | famotidine | MESH:D015738 |
| 1665 | 919-929 | Chemical | denotes | famotidine | MESH:D015738 |
| 1666 | 973-991 | Chemical | denotes | hydroxychloroquine | MESH:D006886 |
| 1667 | 1022-1032 | Chemical | denotes | remdesivir | MESH:C000606551 |
| 1668 | 1224-1234 | Chemical | denotes | Famotidine | MESH:D015738 |
| 1669 | 251-282 | Disease | denotes | gastroesophageal reflux disease | MESH:D005764 |
| 1670 | 299-311 | Disease | denotes | peptic ulcer | MESH:D010437 |
| 1671 | 533-538 | Disease | denotes | death | MESH:D003643 |
| 1672 | 555-563 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1673 | 631-639 | Disease | denotes | COVID-19 | MESH:C000657245 |