PMC:7600245 / 51819-52161 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T230","span":{"begin":72,"end":82},"obj":"Body_part"},{"id":"T231","span":{"begin":89,"end":100},"obj":"Body_part"}],"attributes":[{"id":"A230","pred":"fma_id","subj":"T230","obj":"http://purl.org/sig/ont/fma/fma82773"},{"id":"A231","pred":"fma_id","subj":"T231","obj":"http://purl.org/sig/ont/fma/fma82740"}],"text":"orotate dehydrogenase. It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159]. Accordingly, brequinar possesses immunosuppressive effects. Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160]. Alternative"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T518","span":{"begin":284,"end":292},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"orotate dehydrogenase. It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159]. Accordingly, brequinar possesses immunosuppressive effects. Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160]. Alternative"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T19589","span":{"begin":72,"end":82},"obj":"Chemical"},{"id":"T32360","span":{"begin":89,"end":100},"obj":"Chemical"},{"id":"T11825","span":{"begin":203,"end":217},"obj":"Chemical"},{"id":"T78103","span":{"begin":302,"end":323},"obj":"Chemical"}],"attributes":[{"id":"A42377","pred":"chebi_id","subj":"T19589","obj":"http://purl.obolibrary.org/obo/CHEBI_16898"},{"id":"A71535","pred":"chebi_id","subj":"T32360","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A52718","pred":"chebi_id","subj":"T11825","obj":"http://purl.obolibrary.org/obo/CHEBI_35610"},{"id":"A36856","pred":"chebi_id","subj":"T78103","obj":"http://purl.obolibrary.org/obo/CHEBI_35610"}],"text":"orotate dehydrogenase. It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159]. Accordingly, brequinar possesses immunosuppressive effects. Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160]. Alternative"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T86","span":{"begin":56,"end":68},"obj":"http://purl.obolibrary.org/obo/GO_0009058"}],"text":"orotate dehydrogenase. It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159]. Accordingly, brequinar possesses immunosuppressive effects. Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160]. Alternative"}

{"project":"LitCovid-sentences","denotations":[{"id":"T384","span":{"begin":23,"end":111},"obj":"Sentence"},{"id":"T385","span":{"begin":112,"end":171},"obj":"Sentence"},{"id":"T386","span":{"begin":172,"end":330},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"orotate dehydrogenase. It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159]. Accordingly, brequinar possesses immunosuppressive effects. Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160]. Alternative"}

{"project":"LitCovid-PubTator","denotations":[{"id":"1632","span":{"begin":72,"end":100},"obj":"Chemical"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"orotate dehydrogenase. It eventually blocks the de novo biosynthesis of pyrimidine-based nucleotides [158,159]. Accordingly, brequinar possesses immunosuppressive effects. Furthermore, it also possesses antineoplastic properties that can be exploited to enhance the in vivo antitumor activity of other antineoplastic agents [160]. Alternative"}