PMC:7600245 / 49662-50215
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7600245","sourcedb":"PMC","sourceid":"7600245","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7600245","text":"Vidofludimus is a synthetic small molecule that is under investigation for treating inflammatory bowel disease, multiple sclerosis, and other inflammatory and autoimmune diseases [154,155,156]. It is a biphenyl-carbamoyl-cyclopentene derivative (Figure 7) that is being developed as oral formulation for therapeutic use. Currently, a prospective, randomized, multi-center, double-blinded, and placebo-controlled study is ongoing to evaluate the safety and efficacy of vidofludimus as an adjunct therapy in COVID-19 patients (NCT04379271; n = 230) [157].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T219","span":{"begin":97,"end":102},"obj":"Body_part"}],"attributes":[{"id":"A219","pred":"fma_id","subj":"T219","obj":"http://purl.org/sig/ont/fma/fma7199"},{"subj":"T219","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T213","span":{"begin":84,"end":110},"obj":"Disease"},{"id":"T214","span":{"begin":112,"end":130},"obj":"Disease"},{"id":"T215","span":{"begin":159,"end":178},"obj":"Disease"},{"id":"T216","span":{"begin":506,"end":514},"obj":"Disease"}],"attributes":[{"id":"A213","pred":"mondo_id","subj":"T213","obj":"http://purl.obolibrary.org/obo/MONDO_0005265"},{"id":"A214","pred":"mondo_id","subj":"T214","obj":"http://purl.obolibrary.org/obo/MONDO_0005301"},{"id":"A215","pred":"mondo_id","subj":"T215","obj":"http://purl.obolibrary.org/obo/MONDO_0007179"},{"id":"A216","pred":"mondo_id","subj":"T216","obj":"http://purl.obolibrary.org/obo/MONDO_0100096"},{"subj":"T213","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T214","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T215","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T216","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T493","span":{"begin":16,"end":17},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T494","span":{"begin":200,"end":201},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T495","span":{"begin":332,"end":333},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T493","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T494","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T495","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T25593","span":{"begin":34,"end":42},"obj":"Chemical"},{"id":"T7933","span":{"begin":202,"end":210},"obj":"Chemical"},{"id":"T40831","span":{"begin":211,"end":220},"obj":"Chemical"},{"id":"T2210","span":{"begin":221,"end":233},"obj":"Chemical"}],"attributes":[{"id":"A60863","pred":"chebi_id","subj":"T25593","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A57907","pred":"chebi_id","subj":"T7933","obj":"http://purl.obolibrary.org/obo/CHEBI_17097"},{"id":"A50953","pred":"chebi_id","subj":"T40831","obj":"http://purl.obolibrary.org/obo/CHEBI_23004"},{"id":"A12304","pred":"chebi_id","subj":"T40831","obj":"http://purl.obolibrary.org/obo/CHEBI_33100"},{"id":"A83721","pred":"chebi_id","subj":"T2210","obj":"http://purl.obolibrary.org/obo/CHEBI_49155"},{"subj":"T25593","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T7933","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T40831","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T2210","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T48","span":{"begin":84,"end":110},"obj":"Phenotype"},{"id":"T49","span":{"begin":159,"end":178},"obj":"Phenotype"}],"attributes":[{"id":"A48","pred":"hp_id","subj":"T48","obj":"http://purl.obolibrary.org/obo/HP_0002037"},{"id":"A49","pred":"hp_id","subj":"T49","obj":"http://purl.obolibrary.org/obo/HP_0002960"},{"subj":"T48","pred":"source","obj":"LitCovid-PD-HP"},{"subj":"T49","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T371","span":{"begin":0,"end":193},"obj":"Sentence"},{"id":"T372","span":{"begin":194,"end":320},"obj":"Sentence"},{"id":"T373","span":{"begin":321,"end":553},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T371","pred":"source","obj":"LitCovid-sentences"},{"subj":"T372","pred":"source","obj":"LitCovid-sentences"},{"subj":"T373","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"1566","span":{"begin":515,"end":523},"obj":"Species"},{"id":"1567","span":{"begin":0,"end":12},"obj":"Chemical"},{"id":"1568","span":{"begin":202,"end":233},"obj":"Chemical"},{"id":"1569","span":{"begin":468,"end":480},"obj":"Chemical"},{"id":"1570","span":{"begin":84,"end":110},"obj":"Disease"},{"id":"1571","span":{"begin":112,"end":130},"obj":"Disease"},{"id":"1572","span":{"begin":159,"end":178},"obj":"Disease"},{"id":"1573","span":{"begin":506,"end":514},"obj":"Disease"}],"attributes":[{"id":"A1566","pred":"tao:has_database_id","subj":"1566","obj":"Tax:9606"},{"id":"A1567","pred":"tao:has_database_id","subj":"1567","obj":"MESH:C553728"},{"id":"A1569","pred":"tao:has_database_id","subj":"1569","obj":"MESH:C553728"},{"id":"A1570","pred":"tao:has_database_id","subj":"1570","obj":"MESH:D015212"},{"id":"A1571","pred":"tao:has_database_id","subj":"1571","obj":"MESH:D009103"},{"id":"A1572","pred":"tao:has_database_id","subj":"1572","obj":"MESH:D001327"},{"id":"A1573","pred":"tao:has_database_id","subj":"1573","obj":"MESH:C000657245"},{"subj":"1566","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1567","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1568","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1569","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1570","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1571","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1572","pred":"source","obj":"LitCovid-PubTator"},{"subj":"1573","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#94ec93","default":true},{"id":"LitCovid-PD-MONDO","color":"#ec93ae"},{"id":"LitCovid-PD-CLO","color":"#93c8ec"},{"id":"LitCovid-PD-CHEBI","color":"#e2ec93"},{"id":"LitCovid-PD-HP","color":"#db93ec"},{"id":"LitCovid-sentences","color":"#93ecc1"},{"id":"LitCovid-PubTator","color":"#eca793"}]}]}}