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PMC:7600245 / 48414-49588 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T213 205-213 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T214 798-805 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T215 896-901 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T216 936-945 Body_part denotes epithelia http://purl.org/sig/ont/fma/fma9639
T217 1147-1155 Body_part denotes cytokine http://purl.org/sig/ont/fma/fma84050

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T17 936-945 Body_part denotes epithelia http://purl.obolibrary.org/obo/UBERON_0000483

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T202 65-74 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T203 217-226 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T204 312-321 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T205 371-380 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T206 539-543 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661
T207 607-611 Disease denotes Zika http://purl.obolibrary.org/obo/MONDO_0018661
T208 663-671 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T209 864-872 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T210 875-884 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T211 996-1005 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T212 1165-1173 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T474 9-12 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T475 48-56 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T476 75-76 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T477 81-82 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T478 83-90 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T479 227-228 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T480 233-234 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T481 235-242 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T482 322-323 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T483 324-329 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T484 544-549 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T485 612-617 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T486 646-654 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T487 674-677 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T488 700-701 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T489 732-735 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T490 888-901 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T491 923-928 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T492 929-935 http://purl.obolibrary.org/obo/UBERON_0001005 denotes airway

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T696 4-8 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T697 38-47 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T698 152-160 Chemical denotes naproxen http://purl.obolibrary.org/obo/CHEBI_59527|http://purl.obolibrary.org/obo/CHEBI_7476
T700 205-213 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T701 244-252 Chemical denotes Naproxen http://purl.obolibrary.org/obo/CHEBI_7476
T702 407-421 Chemical denotes clarithromycin http://purl.obolibrary.org/obo/CHEBI_3732
T703 426-434 Chemical denotes naproxen http://purl.obolibrary.org/obo/CHEBI_59527|http://purl.obolibrary.org/obo/CHEBI_7476
T705 438-449 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T706 496-504 Chemical denotes Naproxen http://purl.obolibrary.org/obo/CHEBI_7476
T707 595-603 Chemical denotes cofactor http://purl.obolibrary.org/obo/CHEBI_23357
T708 636-645 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T709 798-805 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T710 846-854 Chemical denotes naproxen http://purl.obolibrary.org/obo/CHEBI_59527|http://purl.obolibrary.org/obo/CHEBI_7476
T712 1079-1087 Chemical denotes naproxen http://purl.obolibrary.org/obo/CHEBI_59527|http://purl.obolibrary.org/obo/CHEBI_7476

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T83 187-201 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T47 1147-1161 Phenotype denotes cytokine storm http://purl.obolibrary.org/obo/HP_0033041

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T361 0-136 Sentence denotes The drug has been reported to exhibit antiviral activity against influenza A and B viruses with IC50 values in the low micromolar range.
T362 137-243 Sentence denotes In this arena, naproxen antagonized CRM1-mediated nuclear export of proteins of influenza A and B viruses.
T363 244-340 Sentence denotes Naproxen also provided therapeutic protection to mice infected with influenza B virus [150,151].
T364 341-495 Sentence denotes In hospitalized patients with influenza, it was found that adding clarithromycin and naproxen to oseltamivir shortened the hospitalization time [150,151].
T365 496-624 Sentence denotes Naproxen also inhibited the replication of Zika virus by reducing the expression of AXL, the entry cofactor of Zika virus [152].
T366 625-806 Sentence denotes Naproxen’s antiviral activity against SARS-CoV-2 has also been proposed by a recent computational work and has been attributed its ability to bind to the viral nucleocapsid protein.
T367 807-1012 Sentence denotes In fact, it was recently reported that naproxen inhibits SARS-CoV-2 infection in Vero E6 cells and in reconstituted human airway epithelia with IC50 values comparable to those effective in influenza [153].
T368 1013-1174 Sentence denotes Lastly, similar to indomethacin, the anti-inflammatory effects of naproxen may also translate into beneficial effects in treating the cytokine storm of COVID-19.

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1527 173-177 Gene denotes CRM1 Gene:7514
1528 580-583 Gene denotes AXL Gene:558
1529 217-234 Gene denotes influenza A and B
1530 65-82 Gene denotes influenza A and B
1531 785-797 Gene denotes nucleocapsid Gene:43740575
1532 293-297 Species denotes mice Tax:10090
1533 312-329 Species denotes influenza B virus Tax:11520
1534 357-365 Species denotes patients Tax:9606
1535 539-549 Species denotes Zika virus Tax:64320
1536 607-617 Species denotes Zika virus Tax:64320
1537 663-673 Species denotes SARS-CoV-2 Tax:2697049
1538 923-928 Species denotes human Tax:9606
1539 371-380 Species denotes influenza Tax:11520
1540 996-1005 Species denotes influenza Tax:11520
1541 152-160 Chemical denotes naproxen MESH:D009288
1542 244-252 Chemical denotes Naproxen MESH:D009288
1543 407-421 Chemical denotes clarithromycin MESH:D017291
1544 426-434 Chemical denotes naproxen MESH:D009288
1545 438-449 Chemical denotes oseltamivir MESH:D053139
1546 496-504 Chemical denotes Naproxen MESH:D009288
1547 846-854 Chemical denotes naproxen MESH:D009288
1548 1032-1044 Chemical denotes indomethacin MESH:D007213
1549 1079-1087 Chemical denotes naproxen MESH:D009288
1550 298-306 Disease denotes infected MESH:D007239
1551 864-884 Disease denotes SARS-CoV-2 infection MESH:C000657245
1552 1165-1173 Disease denotes COVID-19 MESH:C000657245
1553 888-895 CellLine denotes Vero E6 CVCL:0574