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PMC:7600245 / 4612-7674 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T5 219-226 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T6 289-302 Body_part denotes cell membrane http://purl.org/sig/ont/fma/fma63841
T7 289-293 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T8 338-342 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T9 361-368 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T10 437-443 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764
T11 519-523 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T12 560-563 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T13 564-570 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T14 616-623 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T15 731-740 Body_part denotes lysosomes http://purl.org/sig/ont/fma/fma63836
T16 841-847 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T17 880-883 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T18 884-890 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T19 926-937 Body_part denotes nucleotides http://purl.org/sig/ont/fma/fma82740
T20 964-972 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T21 988-996 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T22 1007-1015 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T23 1029-1037 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T24 1041-1049 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T25 1066-1074 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T26 1078-1086 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T27 1112-1120 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T28 1133-1140 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T29 1172-1180 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T30 1233-1240 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T31 1266-1269 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T32 1270-1276 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T33 1548-1551 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T34 1562-1565 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T35 1824-1830 Body_part denotes genome http://purl.org/sig/ont/fma/fma84116
T36 1842-1845 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T37 1867-1874 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T38 1906-1910 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T39 1911-1920 Body_part denotes cytoplasm http://purl.org/sig/ont/fma/fma66835
T40 1953-1961 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T41 2021-2042 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T42 2066-2081 Body_part denotes Golgi apparatus http://purl.org/sig/ont/fma/fma63843
T43 2093-2096 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T44 2123-2131 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T45 2158-2179 Body_part denotes endoplasmic reticulum http://purl.org/sig/ont/fma/fma63842
T46 2199-2210 Body_part denotes compartment http://purl.org/sig/ont/fma/fma76577
T47 2298-2313 Body_part denotes Golgi apparatus http://purl.org/sig/ont/fma/fma63843
T48 2359-2364 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T49 2590-2597 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T22 18-22 Disease denotes SARS http://purl.obolibrary.org/obo/MONDO_0005091
T23 894-902 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T24 2556-2565 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T25 2680-2688 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T16 94-99 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T17 162-163 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T18 190-195 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T19 289-293 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T20 294-302 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T21 316-321 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T22 338-342 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T23 401-410 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T24 462-463 http://purl.obolibrary.org/obo/CLO_0001021 denotes b
T25 508-513 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T26 519-523 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T27 602-607 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T28 652-661 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated
T29 731-740 http://purl.obolibrary.org/obo/GO_0005764 denotes lysosomes
T30 802-811 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membranes
T31 854-855 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T32 905-908 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T33 1159-1167 http://purl.obolibrary.org/obo/UBERON_0000158 denotes membrane
T34 1260-1265 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T35 1309-1314 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T36 1906-1910 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T37 2230-2231 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T38 2239-2244 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T39 2266-2271 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T40 2318-2319 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T41 2359-2364 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T42 2512-2517 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T43 2614-2619 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T44 2652-2653 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T45 2789-2795 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T46 2866-2871 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T28 219-226 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T29 238-249 Chemical denotes angiotensin http://purl.obolibrary.org/obo/CHEBI_48433
T30 361-368 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T31 437-443 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T32 616-623 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T33 926-937 Chemical denotes nucleotides http://purl.obolibrary.org/obo/CHEBI_36976
T34 964-972 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T35 988-996 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T36 1007-1015 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T37 1029-1037 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T38 1041-1049 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T39 1066-1074 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T40 1078-1086 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T41 1112-1120 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T42 1133-1140 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T43 1172-1180 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T44 1233-1240 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T45 1374-1386 Chemical denotes polypeptides http://purl.obolibrary.org/obo/CHEBI_15841
T46 1627-1639 Chemical denotes polypeptides http://purl.obolibrary.org/obo/CHEBI_15841
T47 1867-1874 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T48 1953-1961 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T49 2123-2131 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T50 2431-2440 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T51 2590-2597 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T52 2689-2693 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T53 2747-2763 Chemical denotes antiviral agents http://purl.obolibrary.org/obo/CHEBI_22587
T54 2923-2932 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T6 519-530 http://purl.obolibrary.org/obo/GO_0140253 denotes cell fusion
T7 519-530 http://purl.obolibrary.org/obo/GO_0045026 denotes cell fusion
T8 519-530 http://purl.obolibrary.org/obo/GO_0000768 denotes cell fusion
T9 519-530 http://purl.obolibrary.org/obo/GO_0000747 denotes cell fusion
T10 766-787 http://purl.obolibrary.org/obo/GO_0098997 denotes viral envelope fusion
T11 766-787 http://purl.obolibrary.org/obo/GO_0019064 denotes viral envelope fusion
T12 2047-2058 http://purl.obolibrary.org/obo/GO_0006810 denotes transported
T13 2320-2327 http://purl.obolibrary.org/obo/GO_0007114 denotes budding
T14 2368-2378 http://purl.obolibrary.org/obo/GO_0006887 denotes exocytosis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T36 0-71 Sentence denotes The Life Cycle of SARS-COV-2 and Potential Targets for Drug Development
T37 72-165 Sentence denotes The life cycle of the virus includes early-stage events and later-stage events (Figure 1a,b).
T38 166-311 Sentence denotes In the first stage, the virus utilizes its spike (S) protein to bind to angiotensin converting enzyme 2 (ACE2) on the host cell membrane [13,14].
T39 312-576 Sentence denotes The virus enters the host cell after the spike S protein-ACE2 complex is proteolytically activated by transmembrane protease serine 2 (TMPRSS2) (see (b) in Figure 1), which eventually permits the virus-host cell fusion and the release of the viral RNA genome [15].
T40 577-676 Sentence denotes Alternatively, the bound virus spike S protein can also be proteolytically activated by furin [16].
T41 677-875 Sentence denotes Further processing is promoted by cathepsins in (endo)lysosomes to ultimately aid in the viral envelope fusion with the host membranes and the release of the viral genome (see (a) in Figure 1) [17].
T42 876-1096 Sentence denotes The RNA genome of SARS-CoV-2 has more than 29,800 nucleotides which encode for about 29 proteins: nonstructural proteins (NSPs; 16 proteins), structural proteins (4 proteins), and accessory proteins (9 proteins) [18,19].
T43 1097-1277 Sentence denotes The structural proteins are spike S protein, envelope (E) and membrane (M) proteins which form the viral envelope, and nucleocapsid (N) protein which binds to the virus RNA genome.
T44 1278-1596 Sentence denotes In the post-entry phase of the virus life cycle (Figure 1), the NSPs domain is expressed as two polypeptides which, after processing, produce papain like protease (PLpro) (NSP3), main protease (Mpro) (also known as 3-chymotrypsin-like protease (3CLpro); NSP5) [20], and RNA-dependent RNA polymerase (RdRp; NSP12) [21].
T45 1597-1737 Sentence denotes Initial processing of the two polypeptides is promoted by host proteases, and then, is propagated by the action of the viral PLpro and Mpro.
T46 1738-1831 Sentence denotes The viral RdRp is also responsible for the replication and amplification of the viral genome.
T47 1832-2082 Sentence denotes The viral RNA and the N structural protein are biosynthesized in the host cell cytoplasm, whereas other viral structural proteins including S, M, and E are eventually biosynthesized in the endoplasmic reticulum and transported to the Golgi apparatus.
T48 2083-2254 Sentence denotes The viral RNA–N complex and S, M, and E proteins are then assembled in the endoplasmic reticulum–Golgi intermediate compartment (ERGIC) to produce a mature virus particle.
T49 2255-2404 Sentence denotes The mature virus is then released from the Golgi apparatus via a budding process and next from the host cells by exocytosis (Figure 1) [12,22,23,24].
T50 2405-2566 Sentence denotes Collectively, the goal of antiviral therapeutics is to inhibit one or more events in the life cycle of the virus in order to impede the propagation of infection.
T51 2567-2714 Sentence denotes Along these lines, any protein or event in the virus life cycle can be considered as a molecular target for anti-COVID-19 drug development efforts.
T52 2715-2883 Sentence denotes In this review, we describe the antiviral agents that are currently being tested in clinical trials to block and/or inhibit the advanced events of the virus life cycle.
T53 2884-3062 Sentence denotes Although the majority of the presented antiviral therapeutics target the viral polymerase or the viral proteases, few other therapeutics target other molecular targets (Table 1).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
75 18-28 Species denotes SARS-COV-2 Tax:2697049
83 209-214 Gene denotes spike Gene:43740568
84 238-269 Gene denotes angiotensin converting enzyme 2 Gene:59272
85 271-275 Gene denotes ACE2 Gene:59272
86 369-373 Gene denotes ACE2 Gene:59272
87 414-445 Gene denotes transmembrane protease serine 2 Gene:7113
88 447-454 Gene denotes TMPRSS2 Gene:7113
89 665-670 Gene denotes furin Gene:5045
99 1532-1536 Gene denotes NSP5 Gene:92521
100 1578-1582 Gene denotes RdRp Gene:43740578
101 1748-1752 Gene denotes RdRp Gene:43740578
102 1732-1736 Gene denotes Mpro Gene:8673700
103 1472-1476 Gene denotes Mpro Gene:8673700
104 1722-1727 Gene denotes PLpro Gene:43740578
105 1442-1447 Gene denotes PLpro Gene:43740578
106 894-904 Species denotes SARS-CoV-2 Tax:2697049
107 1216-1228 Gene denotes nucleocapsid Gene:43740575
110 2556-2565 Disease denotes infection MESH:D007239
111 2680-2688 Disease denotes COVID-19 MESH:C000657245