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PMC:7600245 / 42005-44838 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T177 448-451 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T178 575-578 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T179 583-586 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T180 829-832 Body_part denotes HIV http://purl.org/sig/ont/fma/fma278683
T181 949-953 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T182 1745-1752 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T183 1777-1789 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T184 2016-2021 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T185 2181-2186 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T186 2221-2228 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T187 2467-2476 Body_part denotes cytokines http://purl.org/sig/ont/fma/fma84050
T188 2480-2514 Body_part denotes peripheral blood mononuclear cells http://purl.org/sig/ont/fma/fma86713
T189 2509-2514 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T190 2543-2577 Body_part denotes peripheral blood mononuclear cells http://purl.org/sig/ont/fma/fma86713
T191 2572-2577 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T192 2665-2676 Body_part denotes fibroblasts http://purl.org/sig/ont/fma/fma63877

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T9 2491-2496 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T10 2554-2559 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T158 208-224 Disease denotes viral infections http://purl.obolibrary.org/obo/MONDO_0005108
T159 305-313 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T160 350-357 Disease denotes Giardia http://purl.obolibrary.org/obo/MONDO_0001103
T161 407-424 Disease denotes cryptosporidiosis http://purl.obolibrary.org/obo/MONDO_0015474
T162 436-444 Disease denotes diarrhea http://purl.obolibrary.org/obo/MONDO_0001673
T163 648-657 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T164 720-729 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T165 805-811 Disease denotes dengue http://purl.obolibrary.org/obo/MONDO_0005502
T166 834-855 Disease denotes Japanese encephalitis http://purl.obolibrary.org/obo/MONDO_0019209
T167 843-855 Disease denotes encephalitis http://purl.obolibrary.org/obo/MONDO_0019956
T168 933-945 Disease denotes yellow fever http://purl.obolibrary.org/obo/MONDO_0020502
T169 1277-1285 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096
T170 1602-1611 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812
T171 2009-2015 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T172 2589-2598 Disease denotes influenza http://purl.obolibrary.org/obo/MONDO_0005812

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T382 33-34 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T383 91-92 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T384 122-130 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T385 392-397 http://purl.obolibrary.org/obo/CLO_0007225 denotes label
T386 480-483 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T387 501-502 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T388 587-594 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T389 623-626 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T390 658-659 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T391 664-665 http://purl.obolibrary.org/obo/CLO_0001021 denotes B
T392 666-673 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T393 730-737 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T394 742-745 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T395 812-817 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T396 856-861 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T397 922-927 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T398 949-953 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T399 988-996 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T400 1035-1041 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T401 1424-1432 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T402 2016-2021 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T403 2181-2186 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T404 2270-2271 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T405 2369-2377 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T406 2480-2514 http://purl.obolibrary.org/obo/CL_0000842 denotes peripheral blood mononuclear cells
T407 2480-2514 http://purl.obolibrary.org/obo/CL_2000001 denotes peripheral blood mononuclear cells
T408 2519-2525 http://purl.obolibrary.org/obo/NCBITaxon_33208 denotes animal
T409 2543-2577 http://purl.obolibrary.org/obo/CL_0000842 denotes peripheral blood mononuclear cells
T410 2543-2577 http://purl.obolibrary.org/obo/CL_2000001 denotes peripheral blood mononuclear cells
T411 2599-2604 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes virus
T412 2665-2676 http://purl.obolibrary.org/obo/CL_0000057 denotes fibroblasts
T413 2733-2734 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T414 2753-2760 http://purl.obolibrary.org/obo/UBERON_0000473 denotes testing
T415 2792-2801 http://purl.obolibrary.org/obo/CLO_0001658 denotes activated

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T609 35-40 Chemical denotes nitro http://purl.obolibrary.org/obo/CHEBI_29785
T610 51-63 Chemical denotes salicylamide http://purl.obolibrary.org/obo/CHEBI_32114
T611 108-121 Chemical denotes antimicrobial http://purl.obolibrary.org/obo/CHEBI_33281
T612 136-140 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T613 392-397 Chemical denotes label http://purl.obolibrary.org/obo/CHEBI_35209
T614 475-479 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T615 518-533 Chemical denotes antiviral agent http://purl.obolibrary.org/obo/CHEBI_22587
T616 583-586 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T617 685-709 Chemical denotes neuraminidase inhibitors http://purl.obolibrary.org/obo/CHEBI_52425
T618 699-709 Chemical denotes inhibitors http://purl.obolibrary.org/obo/CHEBI_35222
T619 1042-1052 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T620 1167-1185 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T621 1187-1197 Chemical denotes ivermectin http://purl.obolibrary.org/obo/CHEBI_6078
T622 1199-1208 Chemical denotes ribavirin http://purl.obolibrary.org/obo/CHEBI_63580
T623 1209-1219 Chemical denotes ivermectin http://purl.obolibrary.org/obo/CHEBI_6078
T624 1224-1234 Chemical denotes atazanavir http://purl.obolibrary.org/obo/CHEBI_37924
T625 1235-1244 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T626 1361-1365 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T627 1454-1458 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T628 1544-1552 Chemical denotes electron http://purl.obolibrary.org/obo/CHEBI_10545
T629 1634-1644 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T630 1742-1744 Chemical denotes M2 http://purl.obolibrary.org/obo/CHEBI_34827|http://purl.obolibrary.org/obo/CHEBI_51112
T632 1745-1752 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T633 1777-1789 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T634 1879-1888 Chemical denotes glutamate http://purl.obolibrary.org/obo/CHEBI_14321|http://purl.obolibrary.org/obo/CHEBI_29987
T636 1895-1903 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996
T637 1904-1907 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T638 1921-1932 Chemical denotes glutathione http://purl.obolibrary.org/obo/CHEBI_16856|http://purl.obolibrary.org/obo/CHEBI_57925
T640 2221-2228 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T641 2244-2248 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T642 2288-2297 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T643 2301-2306 Chemical denotes thiol http://purl.obolibrary.org/obo/CHEBI_29256|http://purl.obolibrary.org/obo/CHEBI_29917
T645 2646-2649 Chemical denotes INF http://purl.obolibrary.org/obo/CHEBI_52999
T646 2656-2659 Chemical denotes INF http://purl.obolibrary.org/obo/CHEBI_52999
T647 2735-2749 Chemical denotes bronchodilator http://purl.obolibrary.org/obo/CHEBI_35523
T648 2784-2791 Chemical denotes calcium http://purl.obolibrary.org/obo/CHEBI_22984|http://purl.obolibrary.org/obo/CHEBI_29320
T650 2802-2810 Chemical denotes chloride http://purl.obolibrary.org/obo/CHEBI_17996

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T68 208-224 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infections
T69 1544-1561 http://purl.obolibrary.org/obo/GO_0022904 denotes electron transfer
T70 1700-1713 http://purl.obolibrary.org/obo/GO_0006412 denotes translational
T71 1904-1916 http://purl.obolibrary.org/obo/GO_0022831 denotes ion channels
T72 1961-1972 http://purl.obolibrary.org/obo/GO_0045333 denotes respiration
T73 1961-1972 http://purl.obolibrary.org/obo/GO_0007585 denotes respiration
T74 2042-2065 http://purl.obolibrary.org/obo/GO_0000981 denotes transcriptional factors
T75 2042-2057 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T27 305-313 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T28 436-444 Phenotype denotes diarrhea http://purl.obolibrary.org/obo/HP_0002014
T29 843-855 Phenotype denotes encephalitis http://purl.obolibrary.org/obo/HP_0002383
T30 940-945 Phenotype denotes fever http://purl.obolibrary.org/obo/HP_0001945
T31 2009-2015 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T313 0-4 Sentence denotes 4.2.
T314 5-26 Sentence denotes Nitazoxanide (Alinia)
T315 27-131 Sentence denotes It is a nitro-thiazolyl-salicylamide derivative (Figure 7) with a broad-spectrum antimicrobial activity.
T316 132-225 Sentence denotes The drug is effective against various helminthic, protozoal, bacterial, and viral infections.
T317 226-253 Sentence denotes It was approved by the U.S.
T318 254-376 Sentence denotes FDA in 2002 to be used orally for the treatment of diarrhea caused by Cryptosporidium parvum or Giardia lamblia [133,134].
T319 377-470 Sentence denotes It is also off-label used for cryptosporidiosis-associated diarrhea in HIV-infected patients.
T320 471-595 Sentence denotes The drug has been reported as a broad-spectrum antiviral agent that inhibits the replication of several RNA and DNA viruses.
T321 596-738 Sentence denotes Specifically, nitazoxanide has been found to affect influenza A and B viruses as well as neuraminidase inhibitors-resistant influenza viruses.
T322 739-975 Sentence denotes It has also been found to inhibit the replication of coronavirus, dengue virus, HBV, HCV, HIV, Japanese encephalitis virus, norovirus, parainfluenza, rotavirus, respiratory syncytial virus, and yellow fever in cell culture assays [135].
T323 976-1096 Sentence denotes Some of its activity is also potentially attributed to its active metabolite (tizoxanide), desacetyl-nitazoxanide [136].
T324 1097-1356 Sentence denotes Currently, nitazoxanide is being studied alone or in combination with hydroxychloroquine, ivermectin, ribavirin/ivermectin, or atazanavir/ritonavir for the prevention/treatment of COVID-19 in about 17 clinical trials (for details refer to clinicaltrials.gov).
T325 1357-1404 Sentence denotes The drug is associated with several mechanisms.
T326 1405-1577 Sentence denotes The anti-protozoal activity demonstrated by this drug is promoted by the inhibition of pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction [137].
T327 1578-1796 Sentence denotes However, in the case of influenza, nitazoxanide and its metabolite inhibit the viral hemagglutinin maturation at the post-translational phase with no effect on the M2 protein or on the neuraminidase glycoprotein [138].
T328 1797-2072 Sentence denotes Furthermore, nitazoxanide modulates other targets and pathways in vitro including glutamate-gated chloride ion channels and glutathione-S-transferase in nematodes, respiration and other pathways in bacterial and cancer cells, and viral and host transcriptional factors [134].
T329 2073-2239 Sentence denotes In fact, nitazoxanide was shown to in vitro inhibit the replication of coronaviruses, including MERS-CoV in cells and the expression of the viral N protein [136,139].
T330 2240-2384 Sentence denotes The drug was also reported as a non-competitive inhibitor of thiol oxidoreductase ERp57 and thus demonstrated anti-paramyxovirus activity [140].
T331 2385-2539 Sentence denotes Moreover, nitazoxanide was reported to inhibit the production of pro-inflammatory cytokines in peripheral blood mononuclear cells and animal models [136].
T332 2540-2683 Sentence denotes In peripheral blood mononuclear cells exposed to influenza virus, nitazoxanide potentiated the release of INF-α and INF-β by fibroblasts [135].
T333 2684-2833 Sentence denotes In addition, nitazoxanide appears also to act as a bronchodilator in testing models by blocking the calcium-activated chloride channel TMEM16A [141].

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1262 5-17 Chemical denotes Nitazoxanide MESH:C041747
1263 19-25 Chemical denotes Alinia MESH:C041747
1291 685-698 Gene denotes neuraminidase Gene:4758
1292 648-665 Gene denotes influenza A and B
1293 324-346 Species denotes Cryptosporidium parvum Tax:5807
1294 350-365 Species denotes Giardia lamblia Tax:5741
1295 461-469 Species denotes patients Tax:9606
1296 583-594 Species denotes DNA viruses Tax:2080735
1297 720-737 Species denotes influenza viruses Tax:11308
1298 792-803 Species denotes coronavirus Tax:11118
1299 805-817 Species denotes dengue virus Tax:12637
1300 834-861 Species denotes Japanese encephalitis virus Tax:11072
1301 900-927 Species denotes respiratory syncytial virus Tax:12814
1302 819-822 Species denotes HBV Tax:10407
1303 35-63 Chemical denotes nitro-thiazolyl-salicylamide
1304 610-622 Chemical denotes nitazoxanide MESH:C041747
1305 1054-1064 Chemical denotes tizoxanide MESH:C104067
1306 1067-1089 Chemical denotes desacetyl-nitazoxanide MESH:C104067
1307 1108-1120 Chemical denotes nitazoxanide MESH:C041747
1308 1167-1185 Chemical denotes hydroxychloroquine MESH:D006886
1309 1187-1197 Chemical denotes ivermectin MESH:D007559
1310 1199-1208 Chemical denotes ribavirin MESH:D012254
1311 1224-1234 Chemical denotes atazanavir MESH:D000069446
1312 1235-1244 Chemical denotes ritonavir MESH:D019438
1313 208-224 Disease denotes viral infections MESH:D001102
1314 305-313 Disease denotes diarrhea MESH:D003967
1315 407-460 Disease denotes cryptosporidiosis-associated diarrhea in HIV-infected MESH:D003457
1316 940-945 Disease denotes fever MESH:D005334
1317 1277-1285 Disease denotes COVID-19 MESH:C000657245
1334 2646-2651 Gene denotes INF-α Gene:3451
1335 2819-2826 Gene denotes TMEM16A Gene:55107
1336 2144-2157 Species denotes coronaviruses Tax:11118
1337 2169-2177 Species denotes MERS-CoV Tax:1335626
1338 2589-2604 Species denotes influenza virus Tax:11308
1339 1602-1611 Species denotes influenza Tax:11520
1340 1492-1500 Chemical denotes pyruvate MESH:D019289
1341 1613-1625 Chemical denotes nitazoxanide MESH:C041747
1342 1810-1822 Chemical denotes nitazoxanide MESH:C041747
1343 1879-1888 Chemical denotes glutamate MESH:D018698
1344 2082-2094 Chemical denotes nitazoxanide MESH:C041747
1345 2301-2306 Chemical denotes thiol MESH:D013438
1346 2395-2407 Chemical denotes nitazoxanide MESH:C041747
1347 2606-2618 Chemical denotes nitazoxanide MESH:C041747
1348 2697-2709 Chemical denotes nitazoxanide MESH:C041747
1349 2009-2015 Disease denotes cancer MESH:D009369