PMC:7600245 / 38469-42003
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T148 | 323-340 | Body_part | denotes | chromosome region | http://purl.org/sig/ont/fma/fma84688 |
| T149 | 323-333 | Body_part | denotes | chromosome | http://purl.org/sig/ont/fma/fma67093 |
| T150 | 362-369 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T151 | 458-466 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T152 | 474-483 | Body_part | denotes | cytoplasm | http://purl.org/sig/ont/fma/fma66835 |
| T153 | 525-530 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T154 | 650-655 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T155 | 815-823 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T156 | 849-857 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T157 | 910-922 | Body_part | denotes | cell nucleus | http://purl.org/sig/ont/fma/fma63840 |
| T158 | 910-914 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T159 | 930-939 | Body_part | denotes | cytoplasm | http://purl.org/sig/ont/fma/fma66835 |
| T160 | 992-1000 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T161 | 1070-1074 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T162 | 1113-1118 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T163 | 1148-1153 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T164 | 1275-1283 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T165 | 1313-1317 | Body_part | denotes | cell | http://purl.org/sig/ont/fma/fma68646 |
| T166 | 1325-1334 | Body_part | denotes | cytoplasm | http://purl.org/sig/ont/fma/fma66835 |
| T167 | 1615-1618 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T168 | 1881-1889 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
| T169 | 2335-2340 | Body_part | denotes | organ | http://purl.org/sig/ont/fma/fma67498 |
| T170 | 2532-2541 | Body_part | denotes | cytokines | http://purl.org/sig/ont/fma/fma84050 |
| T171 | 2709-2717 | Body_part | denotes | cytokine | http://purl.org/sig/ont/fma/fma84050 |
| T172 | 2784-2794 | Body_part | denotes | macrophage | http://purl.org/sig/ont/fma/fma63261 |
| T173 | 2817-2828 | Body_part | denotes | neutrophils | http://purl.org/sig/ont/fma/fma62860 |
| T174 | 2841-2858 | Body_part | denotes | peritoneal cavity | http://purl.org/sig/ont/fma/fma14704 |
| T175 | 2885-2903 | Body_part | denotes | lipopolysaccharide | http://purl.org/sig/ont/fma/fma82785 |
| T176 | 2912-2916 | Body_part | denotes | lung | http://purl.org/sig/ont/fma/fma7195 |
LitCovid-PD-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T6 | 2335-2340 | Body_part | denotes | organ | http://purl.obolibrary.org/obo/UBERON_0000062 |
| T7 | 2841-2858 | Body_part | denotes | peritoneal cavity | http://purl.obolibrary.org/obo/UBERON_0001179 |
| T8 | 2912-2916 | Body_part | denotes | lung | http://purl.obolibrary.org/obo/UBERON_0002048 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T141 | 245-261 | Disease | denotes | multiple myeloma | http://purl.obolibrary.org/obo/MONDO_0009693 |
| T142 | 254-261 | Disease | denotes | myeloma | http://purl.obolibrary.org/obo/MONDO_0005170 |
| T143 | 518-524 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T144 | 596-601 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T145 | 643-649 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T146 | 832-837 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T147 | 975-980 | Disease | denotes | tumor | http://purl.obolibrary.org/obo/MONDO_0005070 |
| T148 | 1106-1112 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T149 | 1667-1676 | Disease | denotes | influenza | http://purl.obolibrary.org/obo/MONDO_0005812 |
| T150 | 1804-1812 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T151 | 1872-1880 | Disease | denotes | SARS-CoV | http://purl.obolibrary.org/obo/MONDO_0005091 |
| T152 | 2917-2923 | Disease | denotes | injury | http://purl.obolibrary.org/obo/MONDO_0021178 |
| T153 | 2943-2978 | Disease | denotes | acute respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0006502 |
| T154 | 2949-2978 | Disease | denotes | respiratory distress syndrome | http://purl.obolibrary.org/obo/MONDO_0009971 |
| T155 | 3083-3091 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T156 | 3243-3251 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
| T157 | 3482-3490 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T349 | 525-530 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T350 | 650-655 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T351 | 910-914 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T352 | 1070-1074 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T353 | 1113-1118 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T354 | 1148-1153 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T355 | 1214-1217 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T356 | 1238-1239 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T357 | 1313-1317 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T358 | 1366-1376 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activities |
| T359 | 1565-1573 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T360 | 1596-1603 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T361 | 1619-1626 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T362 | 1657-1662 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T363 | 1677-1682 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T364 | 1723-1726 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T365 | 1775-1776 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T366 | 1787-1795 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T367 | 2045-2048 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T368 | 2335-2340 | http://purl.obolibrary.org/obo/UBERON_0003103 | denotes | organ |
| T369 | 2447-2455 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T370 | 2475-2485 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activation |
| T371 | 2502-2511 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signaling |
| T372 | 2545-2546 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T373 | 2582-2583 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T374 | 2584-2589 | http://purl.obolibrary.org/obo/CLO_0007836 | denotes | mouse |
| T375 | 2646-2647 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T376 | 2841-2858 | http://purl.obolibrary.org/obo/UBERON_0001179 | denotes | peritoneal cavity |
| T377 | 2912-2916 | http://purl.obolibrary.org/obo/UBERON_0002048 | denotes | lung |
| T378 | 2912-2916 | http://www.ebi.ac.uk/efo/EFO_0000934 | denotes | lung |
| T379 | 2980-2983 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
| T380 | 3125-3133 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T381 | 3307-3315 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T583 | 49-64 | Chemical | denotes | trifluoromethyl | http://purl.obolibrary.org/obo/CHEBI_50127 |
| T584 | 65-71 | Chemical | denotes | phenyl | http://purl.obolibrary.org/obo/CHEBI_30396 |
| T585 | 72-80 | Chemical | denotes | triazole | http://purl.obolibrary.org/obo/CHEBI_38597 |
| T586 | 87-101 | Chemical | denotes | antineoplastic | http://purl.obolibrary.org/obo/CHEBI_35610 |
| T587 | 108-116 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T588 | 204-217 | Chemical | denotes | dexamethasone | http://purl.obolibrary.org/obo/CHEBI_41879 |
| T589 | 310-319 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T590 | 362-369 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T591 | 458-466 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T592 | 815-823 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T593 | 849-857 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T594 | 915-922 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T595 | 992-1000 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T596 | 1008-1015 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T597 | 1275-1283 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T598 | 1293-1300 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T599 | 1435-1444 | Chemical | denotes | inhibitor | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T600 | 1474-1483 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T601 | 1539-1549 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T602 | 1881-1889 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T603 | 1934-1941 | Chemical | denotes | nucleus | http://purl.obolibrary.org/obo/CHEBI_33252 |
| T604 | 2132-2143 | Chemical | denotes | antioxidant | http://purl.obolibrary.org/obo/CHEBI_22586 |
| T605 | 2396-2406 | Chemical | denotes | inhibitors | http://purl.obolibrary.org/obo/CHEBI_35222 |
| T606 | 2731-2733 | Chemical | denotes | IL | http://purl.obolibrary.org/obo/CHEBI_63895|http://purl.obolibrary.org/obo/CHEBI_74072 |
| T608 | 2885-2903 | Chemical | denotes | lipopolysaccharide | http://purl.obolibrary.org/obo/CHEBI_16412 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T51 | 791-805 | http://purl.obolibrary.org/obo/GO_0051168 | denotes | nuclear export |
| T52 | 832-848 | http://purl.obolibrary.org/obo/GO_0051726 | denotes | tumor suppressor |
| T53 | 975-991 | http://purl.obolibrary.org/obo/GO_0051726 | denotes | tumor suppressor |
| T54 | 1070-1087 | http://purl.obolibrary.org/obo/GO_0007050 | denotes | cell cycle arrest |
| T55 | 1070-1080 | http://purl.obolibrary.org/obo/GO_0007049 | denotes | cell cycle |
| T56 | 1093-1102 | http://purl.obolibrary.org/obo/GO_0097194 | denotes | apoptosis |
| T57 | 1093-1102 | http://purl.obolibrary.org/obo/GO_0006915 | denotes | apoptosis |
| T58 | 1397-1418 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factors |
| T59 | 1397-1410 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T60 | 1992-2006 | http://purl.obolibrary.org/obo/GO_0019068 | denotes | viral assembly |
| T61 | 2086-2100 | http://purl.obolibrary.org/obo/GO_0051168 | denotes | nuclear export |
| T62 | 2183-2204 | http://purl.obolibrary.org/obo/GO_0000981 | denotes | transcription factors |
| T63 | 2183-2196 | http://purl.obolibrary.org/obo/GO_0006351 | denotes | transcription |
| T64 | 2294-2316 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | inflammatory responses |
| T65 | 2502-2511 | http://purl.obolibrary.org/obo/GO_0023052 | denotes | signaling |
| T66 | 2709-2727 | http://purl.obolibrary.org/obo/GO_0001816 | denotes | cytokine secretion |
| T67 | 2718-2727 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T18 | 245-261 | Phenotype | denotes | multiple myeloma | http://purl.obolibrary.org/obo/HP_0006775 |
| T19 | 518-524 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T20 | 596-601 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T21 | 643-649 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T22 | 832-837 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T23 | 975-980 | Phenotype | denotes | tumor | http://purl.obolibrary.org/obo/HP_0002664 |
| T24 | 1106-1112 | Phenotype | denotes | cancer | http://purl.obolibrary.org/obo/HP_0002664 |
| T25 | 2599-2605 | Phenotype | denotes | sepsis | http://purl.obolibrary.org/obo/HP_0100806 |
| T26 | 2949-2969 | Phenotype | denotes | respiratory distress | http://purl.obolibrary.org/obo/HP_0002098 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T288 | 0-4 | Sentence | denotes | 4.1. |
| T289 | 5-31 | Sentence | denotes | Selinexor (Xpovio, KPT330) |
| T290 | 32-128 | Sentence | denotes | Selinexor is bis(trifluoromethyl)phenyl-triazole-based antineoplastic small molecule (Figure 7). |
| T291 | 129-170 | Sentence | denotes | It was first approved in 2019 by the U.S. |
| T292 | 171-262 | Sentence | denotes | FDA and is being prescribed with dexamethasone for refractory or relapsed multiple myeloma. |
| T293 | 263-404 | Sentence | denotes | Selinexor is an orally bioavailable, selective inhibitor of chromosome region maintenance 1 (CRM1) protein (also known as exportin 1 (XPO1)). |
| T294 | 405-531 | Sentence | denotes | CRM1 is the main export factor that shuttles nuclear proteins to the cytoplasm and is typically overexpressed in cancer cells. |
| T295 | 532-656 | Sentence | denotes | Its selective inhibition can assist in restoring the endogenous tumor-suppressing processes so as to eliminate cancer cells. |
| T296 | 657-940 | Sentence | denotes | Specifically, selinexor selectively and irreversibly modifies the essential Cys528 residue in CRM1, and thus, it blocks CRM1-mediated nuclear export of cargo proteins such as tumor suppressor proteins (p21, p53, pRB, BRCA1/2, FOXO, and others) from the cell nucleus to the cytoplasm. |
| T297 | 941-1016 | Sentence | denotes | This leads to the accumulation of tumor suppressor proteins in the nucleus. |
| T298 | 1017-1168 | Sentence | denotes | It also results in decreased levels of oncoproteins, cell cycle arrest, and apoptosis of cancer cells without affecting the normal cells [119,120,121]. |
| T299 | 1169-1419 | Sentence | denotes | Considering the current viral pandemic, CRM1 has been put forward as a facilitator of the export of viral proteins from the nucleus of the host cell to the cytoplasm as well as an amplifier of the activities of pro-inflammatory transcription factors. |
| T300 | 1420-1524 | Sentence | denotes | Thus, the CRM1 inhibitor selinexor may exert relevant antiviral and anti-inflammatory effects [122,123]. |
| T301 | 1525-1693 | Sentence | denotes | In fact, CRM1 inhibitors have exhibited activity against >20 different viruses, including RNA viruses such as respiratory syncytial virus and influenza virus [122,123]. |
| T302 | 1694-1821 | Sentence | denotes | Furthermore, CRM1 inhibition has also been identified in in vitro assays to have a potential activity against SARS-CoV-2 [124]. |
| T303 | 1822-1942 | Sentence | denotes | CRM1 was found to contribute to exporting several SARS-CoV proteins, such as S, N, 9b, Orf3 and Orf6 out of the nucleus. |
| T304 | 1943-2029 | Sentence | denotes | Thus, CRM1 inhibition is expected to inhibit the viral assembly [125,126,127,128,129]. |
| T305 | 2030-2211 | Sentence | denotes | Moreover, CRM1 has also been found to contribute to the nuclear export and functional inactivation of antioxidant, anti-inflammatory, and cytoprotective transcription factors [130]. |
| T306 | 2212-2354 | Sentence | denotes | High levels of CRM1 are found in multiple inflammatory conditions and may magnify inflammatory responses leading to severe organ damage [131]. |
| T307 | 2355-2565 | Sentence | denotes | In this direction, selinexor and similar inhibitors have exhibited potent anti-inflammatory activity by suppressing the activation of NFkB and p38 signaling, leading to reduced cytokines in a variety of models. |
| T308 | 2566-2673 | Sentence | denotes | For example, in a mouse model of sepsis, selinexor increased survival following a lethal dose of endotoxin. |
| T309 | 2674-2859 | Sentence | denotes | Selinexor reduced the inflammatory cytokine secretion of IL-6, TNF-α, and HMGB1 while reducing the numbers of macrophage and polymorphonuclear neutrophils in the mice peritoneal cavity. |
| T310 | 2860-2985 | Sentence | denotes | Selinexor also mitigated lipopolysaccharide-induced lung injury that is similar to acute respiratory distress syndrome [132]. |
| T311 | 2986-3101 | Sentence | denotes | Currently, selinexor is being evaluated in at least two phase 2 randomized trials in the U.S. in COVID-19 patients. |
| T312 | 3102-3534 | Sentence | denotes | One is to evaluate the activity, safety and reduction in mortality of two regimens of low-dose selinexor in patients with moderate or severe COVID-19 (NCT04355676, n = 80) and the other is to evaluate the activity of low-dose selinexor and its effect on the clinical recovery, viral load, length of hospitalization, and rate of morbidity and mortality in participants with severe COVID-19 compared to placebo (NCT04349098, n = 230). |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 1164 | 323-354 | Gene | denotes | chromosome region maintenance 1 | Gene:7514 |
| 1165 | 356-360 | Gene | denotes | CRM1 | Gene:7514 |
| 1166 | 385-395 | Gene | denotes | exportin 1 | Gene:7514 |
| 1167 | 397-401 | Gene | denotes | XPO1 | Gene:7514 |
| 1168 | 405-409 | Gene | denotes | CRM1 | Gene:7514 |
| 1169 | 751-755 | Gene | denotes | CRM1 | Gene:7514 |
| 1170 | 777-781 | Gene | denotes | CRM1 | Gene:7514 |
| 1171 | 859-862 | Gene | denotes | p21 | Gene:644914 |
| 1172 | 864-867 | Gene | denotes | p53 | Gene:7157 |
| 1173 | 869-872 | Gene | denotes | pRB | Gene:5925 |
| 1174 | 874-881 | Gene | denotes | BRCA1/2 | Gene:672 |
| 1175 | 45-80 | Chemical | denotes | bis(trifluoromethyl)phenyl-triazole | |
| 1176 | 204-217 | Chemical | denotes | dexamethasone | MESH:D003907 |
| 1177 | 733-739 | Chemical | denotes | Cys528 | |
| 1178 | 245-261 | Disease | denotes | multiple myeloma | MESH:D009101 |
| 1179 | 518-524 | Disease | denotes | cancer | MESH:D009369 |
| 1180 | 596-601 | Disease | denotes | tumor | MESH:D009369 |
| 1181 | 643-649 | Disease | denotes | cancer | MESH:D009369 |
| 1182 | 832-837 | Disease | denotes | tumor | MESH:D009369 |
| 1183 | 975-980 | Disease | denotes | tumor | MESH:D009369 |
| 1184 | 1081-1087 | Disease | denotes | arrest | MESH:D006323 |
| 1185 | 1106-1112 | Disease | denotes | cancer | MESH:D009369 |
| 1213 | 1209-1213 | Gene | denotes | CRM1 | Gene:7514 |
| 1214 | 1430-1434 | Gene | denotes | CRM1 | Gene:7514 |
| 1215 | 1534-1538 | Gene | denotes | CRM1 | Gene:7514 |
| 1216 | 1707-1711 | Gene | denotes | CRM1 | Gene:7514 |
| 1217 | 1822-1826 | Gene | denotes | CRM1 | Gene:7514 |
| 1218 | 1909-1913 | Gene | denotes | Orf3 | Gene:136991 |
| 1219 | 1949-1953 | Gene | denotes | CRM1 | Gene:7514 |
| 1220 | 2040-2044 | Gene | denotes | CRM1 | Gene:7514 |
| 1221 | 2227-2231 | Gene | denotes | CRM1 | Gene:7514 |
| 1222 | 2498-2501 | Gene | denotes | p38 | Gene:1432 |
| 1223 | 2731-2735 | Gene | denotes | IL-6 | Gene:16193 |
| 1224 | 2737-2742 | Gene | denotes | TNF-α | Gene:21926 |
| 1225 | 2748-2753 | Gene | denotes | HMGB1 | Gene:15289 |
| 1226 | 1635-1662 | Species | denotes | respiratory syncytial virus | Tax:12814 |
| 1227 | 1667-1682 | Species | denotes | influenza virus | Tax:11308 |
| 1228 | 1804-1814 | Species | denotes | SARS-CoV-2 | Tax:2697049 |
| 1229 | 1872-1880 | Species | denotes | SARS-CoV | Tax:694009 |
| 1230 | 2584-2589 | Species | denotes | mouse | Tax:10090 |
| 1231 | 2836-2840 | Species | denotes | mice | Tax:10090 |
| 1232 | 1445-1454 | Chemical | denotes | selinexor | MESH:C585161 |
| 1233 | 2374-2383 | Chemical | denotes | selinexor | MESH:C585161 |
| 1234 | 2607-2616 | Chemical | denotes | selinexor | MESH:C585161 |
| 1235 | 2860-2869 | Chemical | denotes | Selinexor | MESH:C585161 |
| 1236 | 2885-2903 | Chemical | denotes | lipopolysaccharide | MESH:D008070 |
| 1237 | 2599-2605 | Disease | denotes | sepsis | MESH:D018805 |
| 1238 | 2912-2923 | Disease | denotes | lung injury | MESH:D055370 |
| 1239 | 2943-2978 | Disease | denotes | acute respiratory distress syndrome | MESH:D012128 |
| 1250 | 3092-3100 | Species | denotes | patients | Tax:9606 |
| 1251 | 3210-3218 | Species | denotes | patients | Tax:9606 |
| 1252 | 3457-3469 | Species | denotes | participants | Tax:9606 |
| 1253 | 3197-3206 | Chemical | denotes | selinexor | MESH:C585161 |
| 1254 | 3328-3337 | Chemical | denotes | selinexor | MESH:C585161 |
| 1255 | 3083-3091 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1256 | 3159-3168 | Disease | denotes | mortality | MESH:D003643 |
| 1257 | 3243-3251 | Disease | denotes | COVID-19 | MESH:C000657245 |
| 1258 | 3444-3453 | Disease | denotes | mortality | MESH:D003643 |
| 1259 | 3482-3490 | Disease | denotes | COVID-19 | MESH:C000657245 |