PMC:7600245 / 3332-4610 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7600245","sourcedb":"PMC","sourceid":"7600245","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7600245","text":"Considering the current clinical guidelines, remdesivir has been recommended for the treatment of COVID-19 in hospitalized patients with severe disease [9]. Furthermore, favipiravir has been approved for the treatment of COVID-19 in the hospital settings in few countries [10]. Moreover, dexamethasone as an anti-inflammatory drug has also been recommended in patients with COVID-19 who require mechanical ventilation or supplemental oxygen [11]. Despite the above recommendations and/or approvals, the need for effective treatment remains largely unmet. Therefore, a large number of potential therapeutics continue to be developed and others are being advanced into clinical trials. We recently reviewed the chemical and mechanistic aspects of antiviral drugs that block the early phase of the virus life cycle [12]. In this article, we review the chemical structures and the mechanisms of action of potential antiviral therapeutics that block/inhibit the post-entry stages of the virus life cycle. We only include those therapeutics that are listed in clinicatrials.gov. They include both old drugs and new molecular entities. Many of the potential therapeutics are small molecules and few are macromolecules. Some of these therapeutics also possess anti-inflammatory 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