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PMC:7600245 / 32956-33998 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T129 190-195 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T130 401-413 Body_part denotes glycoprotein http://purl.org/sig/ont/fma/fma62925
T131 575-580 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T120 74-82 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T121 85-94 Disease denotes infection http://purl.obolibrary.org/obo/MONDO_0005550
T122 168-176 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T123 345-353 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T124 516-524 Disease denotes SARS-CoV http://purl.obolibrary.org/obo/MONDO_0005091
T125 720-728 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T298 182-195 http://purl.obolibrary.org/obo/CLO_0051719 denotes Vero E6 cells
T299 499-507 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T300 568-574 http://purl.obolibrary.org/obo/CLO_0002172 denotes Caco-2
T301 568-574 http://purl.obolibrary.org/obo/CLO_0051943 denotes Caco-2
T302 568-574 http://purl.obolibrary.org/obo/CLO_0051958 denotes Caco-2
T303 568-574 http://purl.obolibrary.org/obo/CLO_0051960 denotes Caco-2
T304 575-580 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T305 618-619 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T491 0-9 Chemical denotes Darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T492 10-20 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T493 130-139 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T494 291-300 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T495 401-413 Chemical denotes glycoprotein http://purl.obolibrary.org/obo/CHEBI_17089
T496 462-471 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T497 472-482 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T498 669-678 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T499 679-689 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T500 757-766 Chemical denotes darunavir http://purl.obolibrary.org/obo/CHEBI_367163
T501 824-834 Chemical denotes cobicistat http://purl.obolibrary.org/obo/CHEBI_72291
T502 858-867 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T503 868-886 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T504 910-919 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T505 920-931 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T506 933-942 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T507 943-954 Chemical denotes oseltamivir http://purl.obolibrary.org/obo/CHEBI_7798
T508 955-973 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801
T509 978-987 Chemical denotes ritonavir http://purl.obolibrary.org/obo/CHEBI_45409
T510 988-999 Chemical denotes favipiravir http://purl.obolibrary.org/obo/CHEBI_134722
T511 1000-1018 Chemical denotes hydroxychloroquine http://purl.obolibrary.org/obo/CHEBI_5801

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T240 0-95 Sentence denotes Darunavir/cobicistat is under clinical investigation for the treatment of SARS-CoV-2 infection.
T241 96-251 Sentence denotes This is potentially attributed to darunavir ability to in vitro inhibit SARS-CoV-2 in Vero E6 cells, albeit at high concentrations (EC50 = 46.41 µM) [104].
T242 252-356 Sentence denotes Mechanistically, this could be because darunavir potentially inhibits 3CLpro and/or PLpro of SARS-CoV-2.
T243 357-425 Sentence denotes The two enzymes are important for the viral glycoprotein processing.
T244 426-587 Sentence denotes However, in another in vitro study, darunavir/cobicistat demonstrated no activity against SARS-CoV-2 at clinically relevant concentrations in Caco-2 cells [105].
T245 588-744 Sentence denotes Furthermore, the results from a randomized controlled trial in China showed that darunavir/cobicistat was not effective in treating COVID-19 patients [106].
T246 745-1042 Sentence denotes Regardless, darunavir is being tried in about three trials in combination with cobicistat (NCT04252274; n = 30), ritonavir/hydroxychloroquine (NCT04435587; n = 80), ritonavir/oseltamivir, ritonavir/oseltamivir/hydroxychloroquine, or ritonavir/favipiravir/hydroxychloroquine (NCT04303299; n = 320).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
965 336-341 Gene denotes PLpro Gene:43740578
966 168-178 Species denotes SARS-CoV-2 Tax:2697049
967 345-355 Species denotes SARS-CoV-2 Tax:2697049
968 516-526 Species denotes SARS-CoV-2 Tax:2697049
969 729-737 Species denotes patients Tax:9606
970 0-20 Chemical denotes Darunavir/cobicistat
971 130-139 Chemical denotes darunavir MESH:D000069454
972 291-300 Chemical denotes darunavir MESH:D000069454
973 462-472 Chemical denotes darunavir/ MESH:D000069454
974 472-482 Chemical denotes cobicistat MESH:D000069547
975 669-689 Chemical denotes darunavir/cobicistat
976 757-766 Chemical denotes darunavir MESH:D000069454
977 824-834 Chemical denotes cobicistat MESH:D000069547
978 858-886 Chemical denotes ritonavir/hydroxychloroquine
979 910-931 Chemical denotes ritonavir/oseltamivir
980 933-942 Chemical denotes ritonavir MESH:D019438
981 943-954 Chemical denotes oseltamivir MESH:D053139
982 955-973 Chemical denotes hydroxychloroquine MESH:D006886
983 978-1018 Chemical denotes ritonavir/favipiravir/hydroxychloroquine
984 74-94 Disease denotes SARS-CoV-2 infection MESH:C000657245
985 720-728 Disease denotes COVID-19 MESH:C000657245
986 187-189 CellLine denotes E6 CVCL:4582
987 568-574 CellLine denotes Caco-2 CVCL:0025