PMC:7600245 / 32291-32955
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7600245","sourcedb":"PMC","sourceid":"7600245","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7600245","text":"Darunavir (Figure 6) is another antiretroviral drug that competitively inhibits the HIV-1 aspartate protease [101,102]. In addition to the active site, it has been reported that the flexible darunavir binds to another site on the surface of the enzyme, which accounts for its resilience against potential mutations in the targeted protease [103]. Darunavir was approved in 2015 by the U.S. FDA and usually prescribed in combination with the pharmacokinetic booster cobicistat. Although structurally similar to ritonavir, cobicistat lacks antiviral activity due to the lack of the central phenyl-propanol moiety, a key structural feature of HIV protease inhibitors.","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T127","span":{"begin":84,"end":87},"obj":"Body_part"},{"id":"T128","span":{"begin":640,"end":643},"obj":"Body_part"}],"attributes":[{"id":"A127","pred":"fma_id","subj":"T127","obj":"http://purl.org/sig/ont/fma/fma278683"},{"id":"A128","pred":"fma_id","subj":"T128","obj":"http://purl.org/sig/ont/fma/fma278683"},{"subj":"T127","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T128","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T294","span":{"begin":139,"end":145},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T295","span":{"begin":155,"end":158},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T296","span":{"begin":548,"end":556},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T297","span":{"begin":612,"end":613},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T294","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T295","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T296","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T297","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T475","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"T476","span":{"begin":47,"end":51},"obj":"Chemical"},{"id":"T477","span":{"begin":90,"end":99},"obj":"Chemical"},{"id":"T480","span":{"begin":191,"end":200},"obj":"Chemical"},{"id":"T481","span":{"begin":347,"end":356},"obj":"Chemical"},{"id":"T482","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"T483","span":{"begin":510,"end":519},"obj":"Chemical"},{"id":"T484","span":{"begin":521,"end":531},"obj":"Chemical"},{"id":"T485","span":{"begin":538,"end":547},"obj":"Chemical"},{"id":"T486","span":{"begin":588,"end":594},"obj":"Chemical"},{"id":"T487","span":{"begin":640,"end":663},"obj":"Chemical"},{"id":"T488","span":{"begin":644,"end":663},"obj":"Chemical"},{"id":"T490","span":{"begin":653,"end":663},"obj":"Chemical"}],"attributes":[{"id":"A475","pred":"chebi_id","subj":"T475","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A476","pred":"chebi_id","subj":"T476","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A477","pred":"chebi_id","subj":"T477","obj":"http://purl.obolibrary.org/obo/CHEBI_132943"},{"id":"A478","pred":"chebi_id","subj":"T477","obj":"http://purl.obolibrary.org/obo/CHEBI_29995"},{"id":"A479","pred":"chebi_id","subj":"T477","obj":"http://purl.obolibrary.org/obo/CHEBI_72314"},{"id":"A480","pred":"chebi_id","subj":"T480","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A481","pred":"chebi_id","subj":"T481","obj":"http://purl.obolibrary.org/obo/CHEBI_367163"},{"id":"A482","pred":"chebi_id","subj":"T482","obj":"http://purl.obolibrary.org/obo/CHEBI_72291"},{"id":"A483","pred":"chebi_id","subj":"T483","obj":"http://purl.obolibrary.org/obo/CHEBI_45409"},{"id":"A484","pred":"chebi_id","subj":"T484","obj":"http://purl.obolibrary.org/obo/CHEBI_72291"},{"id":"A485","pred":"chebi_id","subj":"T485","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A486","pred":"chebi_id","subj":"T486","obj":"http://purl.obolibrary.org/obo/CHEBI_30396"},{"id":"A487","pred":"chebi_id","subj":"T487","obj":"http://purl.obolibrary.org/obo/CHEBI_35660"},{"id":"A488","pred":"chebi_id","subj":"T488","obj":"http://purl.obolibrary.org/obo/CHEBI_37670"},{"id":"A489","pred":"chebi_id","subj":"T488","obj":"http://purl.obolibrary.org/obo/CHEBI_60258"},{"id":"A490","pred":"chebi_id","subj":"T490","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"subj":"T475","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T476","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T477","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T480","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T481","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T482","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T483","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T484","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T485","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T486","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T487","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T488","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T490","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T235","span":{"begin":0,"end":119},"obj":"Sentence"},{"id":"T236","span":{"begin":120,"end":346},"obj":"Sentence"},{"id":"T237","span":{"begin":347,"end":389},"obj":"Sentence"},{"id":"T238","span":{"begin":390,"end":476},"obj":"Sentence"},{"id":"T239","span":{"begin":477,"end":664},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T235","pred":"source","obj":"LitCovid-sentences"},{"subj":"T236","pred":"source","obj":"LitCovid-sentences"},{"subj":"T237","pred":"source","obj":"LitCovid-sentences"},{"subj":"T238","pred":"source","obj":"LitCovid-sentences"},{"subj":"T239","pred":"source","obj":"LitCovid-sentences"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"934","span":{"begin":84,"end":89},"obj":"Species"},{"id":"935","span":{"begin":0,"end":9},"obj":"Chemical"},{"id":"936","span":{"begin":191,"end":200},"obj":"Chemical"},{"id":"937","span":{"begin":347,"end":356},"obj":"Chemical"},{"id":"938","span":{"begin":465,"end":475},"obj":"Chemical"},{"id":"939","span":{"begin":510,"end":519},"obj":"Chemical"},{"id":"940","span":{"begin":521,"end":531},"obj":"Chemical"},{"id":"941","span":{"begin":588,"end":603},"obj":"Chemical"}],"attributes":[{"id":"A934","pred":"tao:has_database_id","subj":"934","obj":"Tax:11676"},{"id":"A935","pred":"tao:has_database_id","subj":"935","obj":"MESH:D000069454"},{"id":"A936","pred":"tao:has_database_id","subj":"936","obj":"MESH:D000069454"},{"id":"A937","pred":"tao:has_database_id","subj":"937","obj":"MESH:D000069454"},{"id":"A938","pred":"tao:has_database_id","subj":"938","obj":"MESH:D000069547"},{"id":"A939","pred":"tao:has_database_id","subj":"939","obj":"MESH:D019438"},{"id":"A940","pred":"tao:has_database_id","subj":"940","obj":"MESH:D000069547"},{"id":"A941","pred":"tao:has_database_id","subj":"941","obj":"MESH:C439395"},{"subj":"934","pred":"source","obj":"LitCovid-PubTator"},{"subj":"935","pred":"source","obj":"LitCovid-PubTator"},{"subj":"936","pred":"source","obj":"LitCovid-PubTator"},{"subj":"937","pred":"source","obj":"LitCovid-PubTator"},{"subj":"938","pred":"source","obj":"LitCovid-PubTator"},{"subj":"939","pred":"source","obj":"LitCovid-PubTator"},{"subj":"940","pred":"source","obj":"LitCovid-PubTator"},{"subj":"941","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#ba93ec","default":true},{"id":"LitCovid-PD-CLO","color":"#93eca0"},{"id":"LitCovid-PD-CHEBI","color":"#ec939f"},{"id":"LitCovid-sentences","color":"#93b9ec"},{"id":"LitCovid-PubTator","color":"#d3ec93"}]}]}}