PMC:7600245 / 25797-26103 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T107","span":{"begin":87,"end":94},"obj":"Body_part"}],"attributes":[{"id":"A107","pred":"fma_id","subj":"T107","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Then, the monophosphate is transformed to guanosine analog by adenosine deaminase like protein 1 (ADALP1) and further phosphorylated by guanylate kinase 1 (GUK1) and nucleoside diphosphate kinase (NDPK) to the pharmacologically active form of AT-527 diphosphate (also reported as AT-9010) (Figure S3) [78]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T238","span":{"begin":228,"end":234},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"}],"text":"Then, the monophosphate is transformed to guanosine analog by adenosine deaminase like protein 1 (ADALP1) and further phosphorylated by guanylate kinase 1 (GUK1) and nucleoside diphosphate kinase (NDPK) to the pharmacologically active form of AT-527 diphosphate (also reported as AT-9010) (Figure S3) [78]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T358","span":{"begin":42,"end":51},"obj":"Chemical"},{"id":"T359","span":{"begin":62,"end":71},"obj":"Chemical"},{"id":"T360","span":{"begin":87,"end":94},"obj":"Chemical"},{"id":"T361","span":{"begin":166,"end":188},"obj":"Chemical"},{"id":"T362","span":{"begin":166,"end":176},"obj":"Chemical"},{"id":"T363","span":{"begin":177,"end":188},"obj":"Chemical"},{"id":"T365","span":{"begin":250,"end":261},"obj":"Chemical"},{"id":"T367","span":{"begin":297,"end":299},"obj":"Chemical"}],"attributes":[{"id":"A358","pred":"chebi_id","subj":"T358","obj":"http://purl.obolibrary.org/obo/CHEBI_16750"},{"id":"A359","pred":"chebi_id","subj":"T359","obj":"http://purl.obolibrary.org/obo/CHEBI_16335"},{"id":"A360","pred":"chebi_id","subj":"T360","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A361","pred":"chebi_id","subj":"T361","obj":"http://purl.obolibrary.org/obo/CHEBI_16862"},{"id":"A362","pred":"chebi_id","subj":"T362","obj":"http://purl.obolibrary.org/obo/CHEBI_33838"},{"id":"A363","pred":"chebi_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/CHEBI_18361"},{"id":"A364","pred":"chebi_id","subj":"T363","obj":"http://purl.obolibrary.org/obo/CHEBI_33019"},{"id":"A365","pred":"chebi_id","subj":"T365","obj":"http://purl.obolibrary.org/obo/CHEBI_18361"},{"id":"A366","pred":"chebi_id","subj":"T365","obj":"http://purl.obolibrary.org/obo/CHEBI_33019"},{"id":"A367","pred":"chebi_id","subj":"T367","obj":"http://purl.obolibrary.org/obo/CHEBI_29388"}],"text":"Then, the monophosphate is transformed to guanosine analog by adenosine deaminase like protein 1 (ADALP1) and further phosphorylated by guanylate kinase 1 (GUK1) and nucleoside diphosphate kinase (NDPK) to the pharmacologically active form of AT-527 diphosphate (also reported as AT-9010) (Figure S3) [78]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T188","span":{"begin":0,"end":306},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Then, the monophosphate is transformed to guanosine analog by adenosine deaminase like protein 1 (ADALP1) and further phosphorylated by guanylate kinase 1 (GUK1) and nucleoside diphosphate kinase (NDPK) to the pharmacologically active form of AT-527 diphosphate (also reported as AT-9010) (Figure S3) [78]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"714","span":{"begin":136,"end":154},"obj":"Gene"},{"id":"715","span":{"begin":156,"end":160},"obj":"Gene"},{"id":"716","span":{"begin":166,"end":195},"obj":"Gene"},{"id":"717","span":{"begin":197,"end":201},"obj":"Gene"},{"id":"727","span":{"begin":10,"end":23},"obj":"Chemical"},{"id":"728","span":{"begin":42,"end":51},"obj":"Chemical"},{"id":"729","span":{"begin":62,"end":71},"obj":"Chemical"},{"id":"730","span":{"begin":250,"end":261},"obj":"Chemical"}],"attributes":[{"id":"A714","pred":"tao:has_database_id","subj":"714","obj":"Gene:2987"},{"id":"A715","pred":"tao:has_database_id","subj":"715","obj":"Gene:2987"},{"id":"A716","pred":"tao:has_database_id","subj":"716","obj":"Gene:129607"},{"id":"A717","pred":"tao:has_database_id","subj":"717","obj":"Gene:129607"},{"id":"A728","pred":"tao:has_database_id","subj":"728","obj":"MESH:D006151"},{"id":"A729","pred":"tao:has_database_id","subj":"729","obj":"MESH:D000241"},{"id":"A730","pred":"tao:has_database_id","subj":"730","obj":"MESH:D011756"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Then, the monophosphate is transformed to guanosine analog by adenosine deaminase like protein 1 (ADALP1) and further phosphorylated by guanylate kinase 1 (GUK1) and nucleoside diphosphate kinase (NDPK) to the pharmacologically active form of AT-527 diphosphate (also reported as AT-9010) (Figure S3) [78]."}