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PMC:7600245 / 25065-26455 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T101 53-59 Body_part denotes purine http://purl.org/sig/ont/fma/fma82772
T102 60-70 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T103 171-174 Body_part denotes RNA http://purl.org/sig/ont/fma/fma67095
T104 601-610 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T105 617-627 Body_part denotes nucleotide http://purl.org/sig/ont/fma/fma82740
T106 636-643 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T107 819-826 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T97 1168-1177 Disease denotes cirrhosis http://purl.obolibrary.org/obo/MONDO_0005155
T98 1349-1357 Disease denotes COVID-19 http://purl.obolibrary.org/obo/MONDO_0100096

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T229 45-51 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T230 98-101 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T231 122-130 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T232 175-182 http://purl.obolibrary.org/obo/NCBITaxon_10239 denotes viruses
T233 194-199 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T234 243-244 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T235 407-417 http://purl.obolibrary.org/obo/CLO_0001658 denotes activation
T236 470-475 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T237 519-520 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T238 960-966 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T239 1083-1091 http://purl.obolibrary.org/obo/CLO_0001658 denotes activity
T240 1225-1226 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T338 53-70 Chemical denotes purine nucleotide http://purl.obolibrary.org/obo/CHEBI_26395
T339 53-59 Chemical denotes purine http://purl.obolibrary.org/obo/CHEBI_35584
T340 60-70 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T341 71-78 Chemical denotes prodrug http://purl.obolibrary.org/obo/CHEBI_50266
T342 87-89 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T343 112-121 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T344 252-261 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T345 320-332 Chemical denotes sulfate salt http://purl.obolibrary.org/obo/CHEBI_35175
T346 320-327 Chemical denotes sulfate http://purl.obolibrary.org/obo/CHEBI_16189
T347 328-332 Chemical denotes salt http://purl.obolibrary.org/obo/CHEBI_24866|http://purl.obolibrary.org/obo/CHEBI_26710
T349 338-342 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T350 543-551 Chemical denotes L-alanyl http://purl.obolibrary.org/obo/CHEBI_32433|http://purl.obolibrary.org/obo/CHEBI_46217
T352 545-551 Chemical denotes alanyl http://purl.obolibrary.org/obo/CHEBI_22280|http://purl.obolibrary.org/obo/CHEBI_32441
T354 601-610 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T355 617-627 Chemical denotes nucleotide http://purl.obolibrary.org/obo/CHEBI_36976
T356 636-643 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T357 720-730 Chemical denotes metabolite http://purl.obolibrary.org/obo/CHEBI_25212
T358 774-783 Chemical denotes guanosine http://purl.obolibrary.org/obo/CHEBI_16750
T359 794-803 Chemical denotes adenosine http://purl.obolibrary.org/obo/CHEBI_16335
T360 819-826 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T361 898-920 Chemical denotes nucleoside diphosphate http://purl.obolibrary.org/obo/CHEBI_16862
T362 898-908 Chemical denotes nucleoside http://purl.obolibrary.org/obo/CHEBI_33838
T363 909-920 Chemical denotes diphosphate http://purl.obolibrary.org/obo/CHEBI_18361|http://purl.obolibrary.org/obo/CHEBI_33019
T365 982-993 Chemical denotes diphosphate http://purl.obolibrary.org/obo/CHEBI_18361|http://purl.obolibrary.org/obo/CHEBI_33019
T367 1029-1031 Chemical denotes S3 http://purl.obolibrary.org/obo/CHEBI_29388
T368 1073-1082 Chemical denotes antiviral http://purl.obolibrary.org/obo/CHEBI_22587
T369 1188-1192 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T45 689-698 http://purl.obolibrary.org/obo/GO_0009058 denotes formation

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T15 1168-1177 Phenotype denotes cirrhosis http://purl.obolibrary.org/obo/HP_0001394

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T181 0-4 Sentence denotes 2.7.
T182 5-11 Sentence denotes AT-527
T183 12-236 Sentence denotes It is an investigational, orally active, purine nucleotide prodrug (Figure S3), which has exhibited antiviral activity against many single-stranded, enveloped RNA viruses, including human flaviviruses and coronaviruses [77].
T184 237-281 Sentence denotes It is a potent inhibitor of viral RdRp [78].
T185 282-424 Sentence denotes Following oral administration as hemi-sulfate salt, the drug gets converted to the monophosphate form via multiple metabolic activation steps.
T186 425-565 Sentence denotes The first step is catalyzed by the action of human carboxylesterase 1 (CES1) and/or cathepsin A (CatA) to produce the L-alanyl intermediate.
T187 566-731 Sentence denotes Spontaneous hydrolysis followed by histidine triad nucleotide-binding protein 1 (HINT1)-mediated hydrolysis results in the formation of the monophosphate metabolite.
T188 732-1038 Sentence denotes Then, the monophosphate is transformed to guanosine analog by adenosine deaminase like protein 1 (ADALP1) and further phosphorylated by guanylate kinase 1 (GUK1) and nucleoside diphosphate kinase (NDPK) to the pharmacologically active form of AT-527 diphosphate (also reported as AT-9010) (Figure S3) [78].
T189 1039-1183 Sentence denotes The safety, pharmacokinetics, and antiviral activity of AT-527 was earlier established in HCV-infected subjects with and without cirrhosis [79].
T190 1184-1390 Sentence denotes The drug is currently being evaluated in a phase 2 double-blind, randomized, placebo-controlled study to determine its efficacy and safety in patients with moderate COVID-19 symptoms (NCT04396106; n = 190).

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
707 271-275 Gene denotes RdRp Gene:43740578
708 476-494 Gene denotes carboxylesterase 1 Gene:1066
709 496-500 Gene denotes CES1 Gene:1066
710 509-520 Gene denotes cathepsin A Gene:5476
711 522-526 Gene denotes CatA Gene:5476
712 601-645 Gene denotes histidine triad nucleotide-binding protein 1 Gene:3094
713 647-652 Gene denotes HINT1 Gene:3094
714 868-886 Gene denotes guanylate kinase 1 Gene:2987
715 888-892 Gene denotes GUK1 Gene:2987
716 898-927 Gene denotes nucleoside diphosphate kinase Gene:129607
717 929-933 Gene denotes NDPK Gene:129607
718 194-199 Species denotes human Tax:9606
719 217-230 Species denotes coronaviruses Tax:11118
720 470-475 Species denotes human Tax:9606
721 1326-1334 Species denotes patients Tax:9606
722 53-70 Chemical denotes purine nucleotide MESH:D011685
723 315-332 Chemical denotes hemi-sulfate salt
724 365-378 Chemical denotes monophosphate
725 543-551 Chemical denotes L-alanyl
726 706-719 Chemical denotes monophosphate
727 742-755 Chemical denotes monophosphate
728 774-783 Chemical denotes guanosine MESH:D006151
729 794-803 Chemical denotes adenosine MESH:D000241
730 982-993 Chemical denotes diphosphate MESH:D011756
731 1129-1141 Disease denotes HCV-infected MESH:D006526
732 1168-1177 Disease denotes cirrhosis MESH:D005355
733 1349-1357 Disease denotes COVID-19 MESH:C000657245