PMC:7600245 / 22021-22754
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T97 | 205-208 | Body_part | denotes | RNA | http://purl.org/sig/ont/fma/fma67095 |
| T98 | 293-298 | Body_part | denotes | cells | http://purl.org/sig/ont/fma/fma68646 |
| T99 | 456-463 | Body_part | denotes | guanine | http://purl.org/sig/ont/fma/fma82775 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T202 | 69-70 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T203 | 119-120 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T204 | 146-154 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T205 | 209-216 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T206 | 238-239 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T207 | 293-298 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T208 | 304-310 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T209 | 394-400 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T210 | 434-442 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | by human |
| T211 | 721-727 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T297 | 49-54 | Chemical | denotes | group | http://purl.obolibrary.org/obo/CHEBI_24433 |
| T298 | 71-79 | Chemical | denotes | pyrazine | http://purl.obolibrary.org/obo/CHEBI_30953 |
| T299 | 80-91 | Chemical | denotes | carboxamide | http://purl.obolibrary.org/obo/CHEBI_23004|http://purl.obolibrary.org/obo/CHEBI_37622 |
| T301 | 136-145 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T302 | 240-247 | Chemical | denotes | prodrug | http://purl.obolibrary.org/obo/CHEBI_50266 |
| T303 | 319-330 | Chemical | denotes | favipiravir | http://purl.obolibrary.org/obo/CHEBI_134722 |
| T304 | 331-337 | Chemical | denotes | ribose | http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013 |
| T306 | 341-353 | Chemical | denotes | triphosphate | http://purl.obolibrary.org/obo/CHEBI_18036 |
| T307 | 443-455 | Chemical | denotes | hypoxanthine | http://purl.obolibrary.org/obo/CHEBI_17368 |
| T308 | 456-463 | Chemical | denotes | guanine | http://purl.obolibrary.org/obo/CHEBI_16235 |
| T309 | 512-523 | Chemical | denotes | favipiravir | http://purl.obolibrary.org/obo/CHEBI_134722 |
| T310 | 529-535 | Chemical | denotes | ribose | http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013 |
| T312 | 698-704 | Chemical | denotes | ribose | http://purl.obolibrary.org/obo/CHEBI_33942|http://purl.obolibrary.org/obo/CHEBI_47013 |
| T314 | 708-720 | Chemical | denotes | triphosphate | http://purl.obolibrary.org/obo/CHEBI_18036 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T41 | 377-386 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
| T42 | 605-620 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T43 | 681-690 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | formation |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T162 | 0-62 | Sentence | denotes | Favipiravir was originally developed by Fujifilm group, Japan. |
| T163 | 63-155 | Sentence | denotes | It is a pyrazine-carboxamide derivative (Figure 4) with a broad-spectrum antiviral activity. |
| T164 | 156-222 | Sentence | denotes | It selectively and potently inhibits the RdRp of RNA viruses [69]. |
| T165 | 223-299 | Sentence | denotes | Favipiravir is a prodrug that requires bioactivation in host-infected cells. |
| T166 | 300-354 | Sentence | denotes | Its active form is favipiravir-ribose-5′-triphosphate. |
| T167 | 355-566 | Sentence | denotes | The first step in the formation of the active species is potentially catalyzed by human hypoxanthine guanine phosphoribosyl-transferase [70], which converts favipiravir into ribose-5′-monophosphate intermediate. |
| T168 | 567-733 | Sentence | denotes | The latter intermediate undergoes two phosphorylation steps mediated by the action of host kinases leading to the formation of the ribose-5′-triphosphate active form. |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 597 | 197-201 | Gene | denotes | RdRp | Gene:43740578 |
| 598 | 437-442 | Species | denotes | human | Tax:9606 |
| 599 | 0-11 | Chemical | denotes | Favipiravir | MESH:C462182 |
| 600 | 71-91 | Chemical | denotes | pyrazine-carboxamide | MESH:D011718 |
| 601 | 223-234 | Chemical | denotes | Favipiravir | MESH:C462182 |
| 602 | 319-353 | Chemical | denotes | favipiravir-ribose-5′-triphosphate | |
| 603 | 443-455 | Chemical | denotes | hypoxanthine | MESH:D019271 |
| 604 | 512-523 | Chemical | denotes | favipiravir | MESH:C462182 |
| 605 | 529-552 | Chemical | denotes | ribose-5′-monophosphate | MESH:C031626 |
| 606 | 698-720 | Chemical | denotes | ribose-5′-triphosphate | MESH:C025202 |
| 607 | 284-292 | Disease | denotes | infected | MESH:D007239 |