PMC:7600245 / 19285-19543 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T87","span":{"begin":57,"end":64},"obj":"Body_part"},{"id":"T88","span":{"begin":79,"end":89},"obj":"Body_part"},{"id":"T89","span":{"begin":225,"end":228},"obj":"Body_part"}],"attributes":[{"id":"A87","pred":"fma_id","subj":"T87","obj":"http://purl.org/sig/ont/fma/fma82774"},{"id":"A88","pred":"fma_id","subj":"T88","obj":"http://purl.org/sig/ont/fma/fma82740"},{"id":"A89","pred":"fma_id","subj":"T89","obj":"http://purl.org/sig/ont/fma/fma74412"}],"text":"In particular, tenofovir disoproxil (Viread; 2001) is an adenine-based acyclic nucleotide analog (Figure S1) that, following activation, acts as a competitive inhibitor of reverse transcriptase, and subsequently, it leads to DNA chain elongation termination."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T175","span":{"begin":105,"end":107},"obj":"http://purl.obolibrary.org/obo/CLO_0050050"},{"id":"T176","span":{"begin":125,"end":135},"obj":"http://purl.obolibrary.org/obo/CLO_0001658"},{"id":"T177","span":{"begin":145,"end":146},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"In particular, tenofovir disoproxil (Viread; 2001) is an adenine-based acyclic nucleotide analog (Figure S1) that, following activation, acts as a competitive inhibitor of reverse transcriptase, and subsequently, it leads to DNA chain elongation termination."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T231","span":{"begin":15,"end":35},"obj":"Chemical"},{"id":"T232","span":{"begin":15,"end":24},"obj":"Chemical"},{"id":"T235","span":{"begin":37,"end":43},"obj":"Chemical"},{"id":"T236","span":{"begin":57,"end":64},"obj":"Chemical"},{"id":"T237","span":{"begin":79,"end":89},"obj":"Chemical"},{"id":"T238","span":{"begin":159,"end":168},"obj":"Chemical"},{"id":"T239","span":{"begin":225,"end":228},"obj":"Chemical"}],"attributes":[{"id":"A231","pred":"chebi_id","subj":"T231","obj":"http://purl.obolibrary.org/obo/CHEBI_63717"},{"id":"A232","pred":"chebi_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/CHEBI_134504"},{"id":"A233","pred":"chebi_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/CHEBI_63625"},{"id":"A234","pred":"chebi_id","subj":"T232","obj":"http://purl.obolibrary.org/obo/CHEBI_63716"},{"id":"A235","pred":"chebi_id","subj":"T235","obj":"http://purl.obolibrary.org/obo/CHEBI_63718"},{"id":"A236","pred":"chebi_id","subj":"T236","obj":"http://purl.obolibrary.org/obo/CHEBI_16708"},{"id":"A237","pred":"chebi_id","subj":"T237","obj":"http://purl.obolibrary.org/obo/CHEBI_36976"},{"id":"A238","pred":"chebi_id","subj":"T238","obj":"http://purl.obolibrary.org/obo/CHEBI_35222"},{"id":"A239","pred":"chebi_id","subj":"T239","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"}],"text":"In particular, tenofovir disoproxil (Viread; 2001) is an adenine-based acyclic nucleotide analog (Figure S1) that, following activation, acts as a competitive inhibitor of reverse transcriptase, and subsequently, it leads to DNA chain elongation termination."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T36","span":{"begin":180,"end":193},"obj":"http://purl.obolibrary.org/obo/GO_0003968"},{"id":"T37","span":{"begin":180,"end":193},"obj":"http://purl.obolibrary.org/obo/GO_0003899"}],"text":"In particular, tenofovir disoproxil (Viread; 2001) is an adenine-based acyclic nucleotide analog (Figure S1) that, following activation, acts as a competitive inhibitor of reverse transcriptase, and subsequently, it leads to DNA chain elongation termination."}

{"project":"LitCovid-sentences","denotations":[{"id":"T145","span":{"begin":0,"end":258},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"In particular, tenofovir disoproxil (Viread; 2001) is an adenine-based acyclic nucleotide analog (Figure S1) that, following activation, acts as a competitive inhibitor of reverse transcriptase, and subsequently, it leads to DNA chain elongation termination."}

{"project":"LitCovid-PubTator","denotations":[{"id":"521","span":{"begin":15,"end":35},"obj":"Chemical"},{"id":"522","span":{"begin":57,"end":64},"obj":"Chemical"}],"attributes":[{"id":"A521","pred":"tao:has_database_id","subj":"521","obj":"MESH:D000068698"},{"id":"A522","pred":"tao:has_database_id","subj":"522","obj":"MESH:D000225"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"In particular, tenofovir disoproxil (Viread; 2001) is an adenine-based acyclic nucleotide analog (Figure S1) that, following activation, acts as a competitive inhibitor of reverse transcriptase, and subsequently, it leads to DNA chain elongation termination."}