PMC:7600245 / 17544-18271
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T78 | 276-286 | Body_part | denotes | nucleotide | http://purl.org/sig/ont/fma/fma82740 |
| T79 | 418-425 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T80 | 438-441 | Body_part | denotes | DNA | http://purl.org/sig/ont/fma/fma74412 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T65 | 129-140 | Disease | denotes | hepatitis B | http://purl.obolibrary.org/obo/MONDO_0005344 |
| T66 | 129-138 | Disease | denotes | hepatitis | http://purl.obolibrary.org/obo/MONDO_0002251 |
| T67 | 153-162 | Disease | denotes | infection | http://purl.obolibrary.org/obo/MONDO_0005550 |
| T68 | 612-620 | Disease | denotes | myopathy | http://purl.obolibrary.org/obo/MONDO_0005336 |
| T69 | 687-695 | Disease | denotes | COVID-19 | http://purl.obolibrary.org/obo/MONDO_0100096 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T159 | 40-41 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T160 | 139-140 | http://purl.obolibrary.org/obo/CLO_0001021 | denotes | B |
| T161 | 141-146 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T162 | 203-204 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T163 | 269-275 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T164 | 340-346 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | active |
| T165 | 497-498 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T166 | 558-559 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T167 | 658-659 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T168 | 671-672 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T186 | 42-51 | Chemical | denotes | thymidine | http://purl.obolibrary.org/obo/CHEBI_17748 |
| T187 | 52-62 | Chemical | denotes | nucleoside | http://purl.obolibrary.org/obo/CHEBI_33838 |
| T188 | 205-212 | Chemical | denotes | prodrug | http://purl.obolibrary.org/obo/CHEBI_50266 |
| T189 | 276-286 | Chemical | denotes | nucleotide | http://purl.obolibrary.org/obo/CHEBI_36976 |
| T190 | 292-304 | Chemical | denotes | triphosphate | http://purl.obolibrary.org/obo/CHEBI_18036 |
| T191 | 327-339 | Chemical | denotes | triphosphate | http://purl.obolibrary.org/obo/CHEBI_18036 |
| T192 | 418-425 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T193 | 438-441 | Chemical | denotes | DNA | http://purl.obolibrary.org/obo/CHEBI_16991 |
| T194 | 480-489 | Chemical | denotes | clevudine | http://purl.obolibrary.org/obo/CHEBI_135964 |
| T195 | 506-515 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T196 | 631-635 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
LitCovid-PD-GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T27 | 227-242 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
| T28 | 404-417 | http://purl.obolibrary.org/obo/GO_0003968 | denotes | transcriptase |
| T29 | 404-417 | http://purl.obolibrary.org/obo/GO_0003899 | denotes | transcriptase |
| T30 | 438-451 | http://purl.obolibrary.org/obo/GO_0071897 | denotes | DNA synthesis |
| T31 | 442-451 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
| T32 | 506-524 | http://purl.obolibrary.org/obo/GO_0051607 | denotes | antiviral response |
LitCovid-PD-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T9 | 129-138 | Phenotype | denotes | hepatitis | http://purl.obolibrary.org/obo/HP_0012115 |
| T10 | 612-620 | Phenotype | denotes | myopathy | http://purl.obolibrary.org/obo/HP_0003198 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T129 | 0-4 | Sentence | denotes | 2.4. |
| T130 | 5-36 | Sentence | denotes | Clevudine (Levovir and Revovir) |
| T131 | 37-168 | Sentence | denotes | It a thymidine nucleoside analog (Figure 3) that was approved in Korea for the treatment of hepatitis B virus (HBV) infection [60]. |
| T132 | 169-305 | Sentence | denotes | Similar to previous agents, it is a prodrug that requires phosphorylation to form the corresponding active nucleotide, the triphosphate. |
| T133 | 306-457 | Sentence | denotes | Mechanistically, the triphosphate active form appears to noncompetitively inhibit the HBV reverse transcriptase protein priming and DNA synthesis [61]. |
| T134 | 458-626 | Sentence | denotes | Importantly, although clevudine showed a potent antiviral response, its long-term use for more than a year led to the development of viral resistance and myopathy [60]. |
| T135 | 627-727 | Sentence | denotes | The drug is being evaluated in a phase 2 as a treatment for COVID-19 in Korea (NCT04347915; n = 60). |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 439 | 5-14 | Chemical | denotes | Clevudine | MESH:C034935 |
| 440 | 16-23 | Chemical | denotes | Levovir | MESH:C034935 |
| 441 | 28-35 | Chemical | denotes | Revovir | MESH:C034935 |
| 450 | 392-395 | Species | denotes | HBV | Tax:10407 |
| 451 | 42-62 | Chemical | denotes | thymidine nucleoside | |
| 452 | 292-304 | Chemical | denotes | triphosphate | MESH:C005692 |
| 453 | 327-339 | Chemical | denotes | triphosphate | MESH:C005692 |
| 454 | 480-489 | Chemical | denotes | clevudine | MESH:C034935 |
| 455 | 129-162 | Disease | denotes | hepatitis B virus (HBV) infection | MESH:D006509 |
| 456 | 612-620 | Disease | denotes | myopathy | MESH:D009135 |
| 457 | 687-695 | Disease | denotes | COVID-19 | MESH:C000657245 |