PMC:7598148 / 10400-11271 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/7598148","sourcedb":"PMC","sourceid":"7598148","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7598148","text":"Conclusions\nWe presented the case of a 31-year-old mother with mild symptoms of COVID-19 pneumonia who was positive for SARS-CoV-2 infection and who gave birth to a baby girl who was also positive for SARS-CoV-2. This case supports the possibility of trans-placental transmission of SARS-CoV-2. SARS-CoV-2 can likely overcome the placental barrier though its high affinity for ACE-2 expressed in the placenta and fetal organs. This is supported by the detection of SARS-CoV-2 in placental tissue and fetal IgM titers. However, there are few cases suspicious for transplacental SARS-COV-2 transmission, suggesting that the placenta can protect the fetus of an infected mother in most cases. Despite limited evidence, when a strict infection control protocol is followed during delivery, a positive SARS-CoV-2 test in a neonate is likely due to transplacental transmission.","divisions":[{"label":"title","span":{"begin":0,"end":11}}],"tracks":[{"project":"LitCovid-PubTator","denotations":[{"id":"198","span":{"begin":377,"end":382},"obj":"Gene"},{"id":"199","span":{"begin":170,"end":174},"obj":"Species"},{"id":"200","span":{"begin":201,"end":211},"obj":"Species"},{"id":"201","span":{"begin":283,"end":293},"obj":"Species"},{"id":"202","span":{"begin":295,"end":305},"obj":"Species"},{"id":"203","span":{"begin":465,"end":475},"obj":"Species"},{"id":"204","span":{"begin":577,"end":587},"obj":"Species"},{"id":"205","span":{"begin":797,"end":807},"obj":"Species"},{"id":"206","span":{"begin":80,"end":98},"obj":"Disease"},{"id":"207","span":{"begin":120,"end":140},"obj":"Disease"},{"id":"208","span":{"begin":659,"end":667},"obj":"Disease"},{"id":"209","span":{"begin":730,"end":739},"obj":"Disease"}],"attributes":[{"id":"A198","pred":"tao:has_database_id","subj":"198","obj":"Gene:59272"},{"id":"A199","pred":"tao:has_database_id","subj":"199","obj":"Tax:9606"},{"id":"A200","pred":"tao:has_database_id","subj":"200","obj":"Tax:2697049"},{"id":"A201","pred":"tao:has_database_id","subj":"201","obj":"Tax:2697049"},{"id":"A202","pred":"tao:has_database_id","subj":"202","obj":"Tax:2697049"},{"id":"A203","pred":"tao:has_database_id","subj":"203","obj":"Tax:2697049"},{"id":"A204","pred":"tao:has_database_id","subj":"204","obj":"Tax:2697049"},{"id":"A205","pred":"tao:has_database_id","subj":"205","obj":"Tax:2697049"},{"id":"A206","pred":"tao:has_database_id","subj":"206","obj":"MESH:C000657245"},{"id":"A207","pred":"tao:has_database_id","subj":"207","obj":"MESH:C000657245"},{"id":"A208","pred":"tao:has_database_id","subj":"208","obj":"MESH:D007239"},{"id":"A209","pred":"tao:has_database_id","subj":"209","obj":"MESH:D007239"},{"subj":"198","pred":"source","obj":"LitCovid-PubTator"},{"subj":"199","pred":"source","obj":"LitCovid-PubTator"},{"subj":"200","pred":"source","obj":"LitCovid-PubTator"},{"subj":"201","pred":"source","obj":"LitCovid-PubTator"},{"subj":"202","pred":"source","obj":"LitCovid-PubTator"},{"subj":"203","pred":"source","obj":"LitCovid-PubTator"},{"subj":"204","pred":"source","obj":"LitCovid-PubTator"},{"subj":"205","pred":"source","obj":"LitCovid-PubTator"},{"subj":"206","pred":"source","obj":"LitCovid-PubTator"},{"subj":"207","pred":"source","obj":"LitCovid-PubTator"},{"subj":"208","pred":"source","obj":"LitCovid-PubTator"},{"subj":"209","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-PD-HP","denotations":[{"id":"T16","span":{"begin":89,"end":98},"obj":"Phenotype"}],"attributes":[{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0002090"},{"subj":"T16","pred":"source","obj":"LitCovid-PD-HP"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T90","span":{"begin":0,"end":11},"obj":"Sentence"},{"id":"T91","span":{"begin":12,"end":212},"obj":"Sentence"},{"id":"T92","span":{"begin":213,"end":294},"obj":"Sentence"},{"id":"T93","span":{"begin":295,"end":426},"obj":"Sentence"},{"id":"T94","span":{"begin":427,"end":517},"obj":"Sentence"},{"id":"T95","span":{"begin":518,"end":689},"obj":"Sentence"},{"id":"T96","span":{"begin":690,"end":871},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T90","pred":"source","obj":"LitCovid-sentences"},{"subj":"T91","pred":"source","obj":"LitCovid-sentences"},{"subj":"T92","pred":"source","obj":"LitCovid-sentences"},{"subj":"T93","pred":"source","obj":"LitCovid-sentences"},{"subj":"T94","pred":"source","obj":"LitCovid-sentences"},{"subj":"T95","pred":"source","obj":"LitCovid-sentences"},{"subj":"T96","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PubTator","color":"#e393ec","default":true},{"id":"LitCovid-PD-HP","color":"#93ecc9"},{"id":"LitCovid-sentences","color":"#ecaf93"}]}]}}