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PMC:7594251 / 94313-95568 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T197 175-182 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T198 252-262 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T199 347-357 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T200 433-440 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T201 483-490 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T202 748-759 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739
T203 944-955 Body_part denotes amino acids http://purl.org/sig/ont/fma/fma82739

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T107 94-97 Disease denotes SOS http://purl.obolibrary.org/obo/MONDO_0011604
T108 114-117 Disease denotes STD http://purl.obolibrary.org/obo/MONDO_0021681
T109 301-304 Disease denotes SOS http://purl.obolibrary.org/obo/MONDO_0011604
T110 1046-1049 Disease denotes SOS http://purl.obolibrary.org/obo/MONDO_0011604
T111 1148-1151 Disease denotes SOS http://purl.obolibrary.org/obo/MONDO_0011604

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T665 0-1 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T666 84-92 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeling
T667 233-234 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T668 521-524 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T669 772-775 http://purl.obolibrary.org/obo/CLO_0037067 denotes Val
T670 1213-1214 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T570 143-149 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T571 175-182 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T572 252-262 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T573 252-257 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T574 258-262 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T575 332-338 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T576 347-357 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T577 347-352 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T578 353-357 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T579 433-440 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T580 483-490 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T581 491-497 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T582 596-609 Chemical denotes benzimidazole http://purl.obolibrary.org/obo/CHEBI_36622|http://purl.obolibrary.org/obo/CHEBI_41275
T584 632-639 Chemical denotes uridine http://purl.obolibrary.org/obo/CHEBI_16704
T585 672-682 Chemical denotes UDP-GlcNAc http://purl.obolibrary.org/obo/CHEBI_16264
T586 672-675 Chemical denotes UDP http://purl.obolibrary.org/obo/CHEBI_17659|http://purl.obolibrary.org/obo/CHEBI_58223
T588 676-682 Chemical denotes GlcNAc http://purl.obolibrary.org/obo/CHEBI_506227|http://purl.obolibrary.org/obo/CHEBI_73685
T590 748-759 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T591 748-753 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T592 754-759 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T593 767-770 Chemical denotes Ile http://purl.obolibrary.org/obo/CHEBI_17191|http://purl.obolibrary.org/obo/CHEBI_30009
T595 772-775 Chemical denotes Val http://purl.obolibrary.org/obo/CHEBI_16414|http://purl.obolibrary.org/obo/CHEBI_30015
T597 777-780 Chemical denotes Leu http://purl.obolibrary.org/obo/CHEBI_15603|http://purl.obolibrary.org/obo/CHEBI_25017|http://purl.obolibrary.org/obo/CHEBI_30006
T600 782-785 Chemical denotes Met http://purl.obolibrary.org/obo/CHEBI_16044|http://purl.obolibrary.org/obo/CHEBI_16643|http://purl.obolibrary.org/obo/CHEBI_16811
T603 793-796 Chemical denotes Trp http://purl.obolibrary.org/obo/CHEBI_16828|http://purl.obolibrary.org/obo/CHEBI_27897|http://purl.obolibrary.org/obo/CHEBI_29954
T606 798-801 Chemical denotes Phe http://purl.obolibrary.org/obo/CHEBI_17295|http://purl.obolibrary.org/obo/CHEBI_29997
T608 891-897 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T609 944-955 Chemical denotes amino acids http://purl.obolibrary.org/obo/CHEBI_33709
T610 944-949 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T611 950-955 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T612 1001-1007 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T613 1098-1102 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
979 581-609 Chemical denotes 2-(3′-pyridyl)-benzimidazole
980 632-670 Chemical denotes uridine diphosphateN-acetylglucosamine
981 672-682 Chemical denotes UDP-GlcNAc
982 767-770 Chemical denotes Ile MESH:D007532
983 772-775 Chemical denotes Val MESH:D014633
984 777-780 Chemical denotes Leu MESH:D007930
985 793-796 Chemical denotes Trp MESH:D014364
986 798-801 Chemical denotes Phe MESH:D010649
987 803-806 Chemical denotes His MESH:D006639

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T614 0-263 Sentence denotes A third method called structural information using Overhauser effects and selective labeling (SOS-NMR), relies of STD experiments performed on ligand complexes with different protein samples that have been fully deuterated excluding a specific type of amino acid.
T615 264-506 Sentence denotes In other words, the data obtained by SOS-NMR gives insight into the ligand-binding amino acid composition and when taken into consideration the 3D structure of targeted protein can be used to establish the structure of protein-ligand complex.
T616 507-684 Sentence denotes This approach has been demonstrated using two complexes—FKBP complexed to 2-(3′-pyridyl)-benzimidazole and MurA complexed to uridine diphosphateN-acetylglucosamine (UDP-GlcNAc).
T617 685-766 Sentence denotes The results showed that for FKBP and MurA, only four and three amino acids (FKBP:
T618 767-792 Sentence denotes Ile, Val, Leu, Met; MurA:
T619 793-911 Sentence denotes Trp, Phe, His) were needed to be selectively protonated in perdeuterated samples to establish the ligand-binding site.
T620 912-1024 Sentence denotes Additionally, on average only 6 amino acids were required for accurate identification of ligand-binding surface.
T621 1025-1127 Sentence denotes According to authors SOS-NMR can greatly improve the early stages of the drug discovery process [397].
T622 1128-1255 Sentence denotes Moreover, combining SOS-NMR with other methods can even further increase chances for a positive outcome of an experiment [398].