PMC:7594251 / 87878-88183 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T173","span":{"begin":196,"end":203},"obj":"Body_part"},{"id":"T174","span":{"begin":204,"end":211},"obj":"Body_part"}],"attributes":[{"id":"A173","pred":"fma_id","subj":"T173","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A174","pred":"fma_id","subj":"T174","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"An example of the combination of NMR with SPR and X-ray crystallography can be found in the work of Fry et al., where the authors sought to understand how the nutlin molecule inhibits MDM2-p53, a protein-protein interaction that has been an important cancer therapy target for several years [381,382,383]."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T100","span":{"begin":251,"end":257},"obj":"Disease"}],"attributes":[{"id":"A100","pred":"mondo_id","subj":"T100","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"}],"text":"An example of the combination of NMR with SPR and X-ray crystallography can be found in the work of Fry et al., where the authors sought to understand how the nutlin molecule inhibits MDM2-p53, a protein-protein interaction that has been an important cancer therapy target for several years [381,382,383]."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T632","span":{"begin":194,"end":195},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T633","span":{"begin":229,"end":232},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"}],"text":"An example of the combination of NMR with SPR and X-ray crystallography can be found in the work of Fry et al., where the authors sought to understand how the nutlin molecule inhibits MDM2-p53, a protein-protein interaction that has been an important cancer therapy target for several years [381,382,383]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T496","span":{"begin":166,"end":174},"obj":"Chemical"},{"id":"T497","span":{"begin":196,"end":203},"obj":"Chemical"},{"id":"T498","span":{"begin":204,"end":211},"obj":"Chemical"}],"attributes":[{"id":"A496","pred":"chebi_id","subj":"T496","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A497","pred":"chebi_id","subj":"T497","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A498","pred":"chebi_id","subj":"T498","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"}],"text":"An example of the combination of NMR with SPR and X-ray crystallography can be found in the work of Fry et al., where the authors sought to understand how the nutlin molecule inhibits MDM2-p53, a protein-protein interaction that has been an important cancer therapy target for several years [381,382,383]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"903","span":{"begin":184,"end":188},"obj":"Gene"},{"id":"904","span":{"begin":189,"end":192},"obj":"Gene"},{"id":"925","span":{"begin":251,"end":257},"obj":"Disease"}],"attributes":[{"id":"A903","pred":"tao:has_database_id","subj":"903","obj":"Gene:4193"},{"id":"A904","pred":"tao:has_database_id","subj":"904","obj":"Gene:7157"},{"id":"A925","pred":"tao:has_database_id","subj":"925","obj":"MESH:D009369"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"An example of the combination of NMR with SPR and X-ray crystallography can be found in the work of Fry et al., where the authors sought to understand how the nutlin molecule inhibits MDM2-p53, a protein-protein interaction that has been an important cancer therapy target for several years [381,382,383]."}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T16","span":{"begin":251,"end":257},"obj":"Phenotype"}],"attributes":[{"id":"A16","pred":"hp_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"An example of the combination of NMR with SPR and X-ray crystallography can be found in the work of Fry et al., where the authors sought to understand how the nutlin molecule inhibits MDM2-p53, a protein-protein interaction that has been an important cancer therapy target for several years [381,382,383]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T572","span":{"begin":0,"end":305},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"An example of the combination of NMR with SPR and X-ray crystallography can be found in the work of Fry et al., where the authors sought to understand how the nutlin molecule inhibits MDM2-p53, a protein-protein interaction that has been an important cancer therapy target for several years [381,382,383]."}