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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T159 268-275 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T160 1035-1044 Body_part denotes histidine http://purl.org/sig/ont/fma/fma82755
T161 1094-1104 Body_part denotes histidines http://purl.org/sig/ont/fma/fma82755

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T81 158-165 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T82 315-322 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065
T83 467-474 Disease denotes amyloid http://purl.obolibrary.org/obo/MONDO_0019065

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T593 134-135 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T594 550-557 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T595 887-888 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T596 889-892 http://purl.obolibrary.org/obo/CLO_0053733 denotes 1:1
T597 903-910 http://purl.obolibrary.org/obo/PR_000018263 denotes peptide
T598 1134-1135 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T363 29-40 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T3032 145-149 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T26284 158-172 Chemical denotes amyloid fibril http://purl.obolibrary.org/obo/CHEBI_60425
T367 188-193 Chemical denotes ester http://purl.obolibrary.org/obo/CHEBI_35701
T45869 213-217 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T22041 226-230 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T18081 268-275 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T372 457-462 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888
T24146 533-535 Chemical denotes Ac http://purl.obolibrary.org/obo/CHEBI_33337|http://purl.obolibrary.org/obo/CHEBI_40574
T78081 550-557 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T62710 571-574 Chemical denotes HHQ http://purl.obolibrary.org/obo/CHEBI_75306
T29394 605-608 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T73677 610-613 Chemical denotes HHQ http://purl.obolibrary.org/obo/CHEBI_75306
T93881 652-655 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T21514 663-666 Chemical denotes HHQ http://purl.obolibrary.org/obo/CHEBI_75306
T81340 776-779 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T13193 845-848 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T72066 873-876 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T34901 899-902 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T47363 903-910 Chemical denotes peptide http://purl.obolibrary.org/obo/CHEBI_16670
T21736 1001-1009 Chemical denotes zinc ion http://purl.obolibrary.org/obo/CHEBI_27365
T1487 1001-1005 Chemical denotes zinc http://purl.obolibrary.org/obo/CHEBI_27363|http://purl.obolibrary.org/obo/CHEBI_30185
T21535 1006-1009 Chemical denotes ion http://purl.obolibrary.org/obo/CHEBI_24870
T390 1035-1044 Chemical denotes histidine http://purl.obolibrary.org/obo/CHEBI_27570
T68900 1116-1119 Chemical denotes Zn2 http://purl.obolibrary.org/obo/CHEBI_37256
T5849 1121-1125 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
808 188-193 Chemical denotes ester MESH:D004952
809 533-557 Chemical denotes Ac-IHVHLQI-CONH2 peptide
810 605-609 Chemical denotes Zn2+
811 610-613 Chemical denotes HHQ
812 652-656 Chemical denotes Zn2+
813 744-747 Chemical denotes His MESH:D006639
814 776-780 Chemical denotes Zn2+
815 808-811 Chemical denotes His MESH:D006639
816 845-849 Chemical denotes Zn2+
817 873-877 Chemical denotes Zn2+
818 893-898 Chemical denotes metal MESH:D008670
819 1035-1054 Chemical denotes histidine nitrogens
820 1094-1104 Chemical denotes histidines MESH:D006639
821 1116-1120 Chemical denotes Zn2+
822 1136-1141 Chemical denotes metal MESH:D008670
823 1142-1153 Chemical denotes imidazolate

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T533 0-205 Sentence denotes Another example of practical application of ssNMR is the work of Lee and colleagues [363] in which they investigated the structure of a designed zinc-binding amyloid fibril that catalyzed ester hydrolysis.
T534 206-339 Sentence denotes Metals ions such as zinc where found to affect the process of protein aggregation which resulted in arise of amyloid like structures.
T535 340-498 Sentence denotes Therefore, understanding the processes of aggregation and the factors related to them is crucial for creation of new drugs for amyloid related diseases [364].
T536 499-627 Sentence denotes In the experiment Lee et al. used Ac-IHVHLQI-CONH2 peptide (referred as HHQ) to form fibrils with varying Zn2+:HHQ molar ratios.
T537 628-858 Sentence denotes The results showed that Zn2+-bound HHQ fibrils form parallel-in-register form of packing β-strand in each sheet and His residues are coordinated to Zn2+ via Nδ1, while half of the His residues are also coordinated to Zn2+ via Nε2.
T538 859-917 Sentence denotes Additionally, Zn2+ binds in a 1:1 metal ion/peptide ratio.
T539 918-1081 Sentence denotes After further analysis using structural bioinformatics, it was concluded that each zinc ion was coordinated by three histidine nitrogens from two adjacent strands.
T540 1082-1166 Sentence denotes Half of all histidines bridged to Zn2+ ions forming a metal–imidazolate chain [363].