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PMC:7594251 / 80404-81587 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T153 759-764 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T154 769-773 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T155 792-798 Body_part denotes breast http://purl.org/sig/ont/fma/fma9601
T156 817-821 Body_part denotes lung http://purl.org/sig/ont/fma/fma7195
T157 1144-1149 Body_part denotes sugar http://purl.org/sig/ont/fma/fma82737
T158 1167-1171 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T31 792-798 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T32 817-821 Body_part denotes lung http://purl.obolibrary.org/obo/UBERON_0002048

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T76 752-758 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T77 792-805 Disease denotes breast cancer http://purl.obolibrary.org/obo/MONDO_0007254
T78 799-805 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T79 817-828 Disease denotes lung cancer http://purl.obolibrary.org/obo/MONDO_0008903
T80 822-828 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T569 292-293 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T570 364-365 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T571 386-387 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T572 419-420 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T573 452-453 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T574 571-572 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T575 681-682 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T576 759-764 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T577 769-779 http://purl.obolibrary.org/obo/CLO_0000031 denotes cell lines
T578 780-790 http://purl.obolibrary.org/obo/CLO_0007634 denotes MDA-MB-231
T579 780-790 http://purl.obolibrary.org/obo/CLO_0037291 denotes MDA-MB-231
T580 792-798 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T581 811-815 http://purl.obolibrary.org/obo/CLO_0001601 denotes A549
T582 811-815 http://purl.obolibrary.org/obo/CLO_0050025 denotes A549
T583 811-815 http://purl.obolibrary.org/obo/CLO_0054264 denotes A549
T584 811-815 http://purl.obolibrary.org/obo/CLO_0054265 denotes A549
T585 811-815 http://purl.obolibrary.org/obo/CLO_0054266 denotes A549
T586 811-815 http://purl.obolibrary.org/obo/CLO_0054267 denotes A549
T587 811-815 http://purl.obolibrary.org/obo/CLO_0054268 denotes A549
T588 811-815 http://purl.obolibrary.org/obo/CLO_0054269 denotes A549
T589 817-821 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T590 817-821 http://www.ebi.ac.uk/efo/EFO_0000934 denotes lung
T591 853-854 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T592 1167-1171 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T56301 20-31 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T341 43-47 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T84891 114-118 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T79986 164-171 Chemical denotes Polymer http://purl.obolibrary.org/obo/CHEBI_60027
T82842 217-221 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T14373 258-262 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T346 294-298 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T66493 299-306 Chemical denotes carrier http://purl.obolibrary.org/obo/CHEBI_78059
T348 388-396 Chemical denotes fructose http://purl.obolibrary.org/obo/CHEBI_28757
T3609 421-425 Chemical denotes PMAA http://purl.obolibrary.org/obo/CHEBI_53429
T350 474-482 Chemical denotes platinum http://purl.obolibrary.org/obo/CHEBI_33364|http://purl.obolibrary.org/obo/CHEBI_33400
T352 590-598 Chemical denotes platinum http://purl.obolibrary.org/obo/CHEBI_33364|http://purl.obolibrary.org/obo/CHEBI_33400
T61798 695-697 Chemical denotes LL http://purl.obolibrary.org/obo/CHEBI_73531
T51558 702-710 Chemical denotes platinum http://purl.obolibrary.org/obo/CHEBI_33364|http://purl.obolibrary.org/obo/CHEBI_33400
T28706 780-783 Chemical denotes MDA http://purl.obolibrary.org/obo/CHEBI_566274
T28722 868-870 Chemical denotes HL http://purl.obolibrary.org/obo/CHEBI_5729
T59735 879-887 Chemical denotes platinum http://purl.obolibrary.org/obo/CHEBI_33364|http://purl.obolibrary.org/obo/CHEBI_33400
T76399 987-989 Chemical denotes LL http://purl.obolibrary.org/obo/CHEBI_73531
T77435 1018-1020 Chemical denotes HL http://purl.obolibrary.org/obo/CHEBI_5729

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
784 421-425 Chemical denotes PMAA MESH:C030613
785 474-482 Chemical denotes platinum MESH:D010984
786 590-598 Chemical denotes platinum MESH:D010984
787 702-710 Chemical denotes platinum MESH:D010984
788 879-887 Chemical denotes platinum MESH:D010984
789 1144-1149 Chemical denotes sugar MESH:D000073893
790 388-414 Disease denotes fructose hydrophilic block MESH:D006327
791 649-661 Disease denotes cytotoxicity MESH:D064420

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T51549 628-634 http://purl.obolibrary.org/obo/GO_0098739 denotes uptake
T68041 628-634 http://purl.obolibrary.org/obo/GO_0098657 denotes uptake

LitCovid-PD-HP

Id Subject Object Predicate Lexical cue hp_id
T12 752-758 Phenotype denotes cancer http://purl.obolibrary.org/obo/HP_0002664
T13 792-805 Phenotype denotes breast cancer http://purl.obolibrary.org/obo/HP_0003002
T14 817-828 Phenotype denotes lung cancer http://purl.obolibrary.org/obo/HP_0100526

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T526 0-163 Sentence denotes An example of ssNMR application related to drug design is the work of Callari et al., who monitored the effect of drug loading on the properties of micelles [362].
T527 164-350 Sentence denotes Polymer micelles are widely used as nano-carries for drug delivery, but so far the effects of drug loading on the morphology of a drug carrier had not been thoroughly investigated [362].
T528 351-504 Sentence denotes They created a model consisting of a fructose hydrophilic block and a PMAA block (micelle), to which a different amount of platinum complex was anchored.
T529 505-662 Sentence denotes The results from this experiment showed that micelles loaded with a higher amount of platinum complex had reduced cellular uptake, release, and cytotoxicity.
T530 663-896 Sentence denotes The micelles with a lower load (LL) of platinum complex were more effective at targeting cancer cells (of cell lines MDA-MB-231 (breast cancer) and A549 (lung cancer) than the micelles with a higher load (HL) of the platinum complex.
T531 897-1030 Sentence denotes This is evidenced by the lower IC50 (half maximal inhibitory concentration) values of the LL micelles as compared to the HL micelles.
T532 1031-1183 Sentence denotes Both of those results could be related to the micellar structure and their potential for interaction between the sugar moieties and the cell wall [362].