PMC:7594251 / 78093-79395 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7594251","sourcedb":"PMC","sourceid":"7594251","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7594251","text":"ssNMR differs from liquid state NMR by the presence of anisotropic interactions. In liquids NMR these effects are averaged to zero as a consequence of rapid molecular tumbling. In solid state however, the molecules are not tumbling rapidly and the residual effects of anisotropic (orientation depended) interactions such as anisotropic chemical shift, magnetic dipolar coupling, and quadrupolar coupling could be observed in the form of broad peaks, with could be much wider than the chemical shift range of the nucleus [355,358,359]. As a results, there has been a constant effort to improve the sensitivity and resolution of solid state NMR spectra, which increased the potential of ssNMR in future applications [360]. One of the methods that works for nuclei with spin value of I = 1/2 is called magic-angle spinning (MAS). It increases the resolution by rapidly rotating the sample around a fixed (or so-called magic) angle of 54.736° [360]. This method can be combined with decoupling, to remove the dipolar couplings between spins. This is done by applying radiofrequency pulses or cross-polarization (CP) transfer of magnetization from abundant and sensitive nuclei such as 1H to less sensitive such as 13C [328,333]. A broader comparison between ssNMR and liquid state NMR is provided in [361].","tracks":[{"project":"LitCovid-PD-CLO","denotations":[{"id":"T552","span":{"begin":134,"end":135},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T553","span":{"begin":538,"end":539},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T554","span":{"begin":555,"end":558},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T555","span":{"begin":564,"end":565},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T556","span":{"begin":893,"end":894},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T557","span":{"begin":1108,"end":1110},"obj":"http://purl.obolibrary.org/obo/PR_000005794"},{"id":"T558","span":{"begin":1225,"end":1226},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"attributes":[{"subj":"T552","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T553","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T554","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T555","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T556","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T557","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T558","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T66289","span":{"begin":205,"end":214},"obj":"Chemical"},{"id":"T19025","span":{"begin":512,"end":519},"obj":"Chemical"},{"id":"T38899","span":{"begin":755,"end":761},"obj":"Chemical"},{"id":"T96153","span":{"begin":1108,"end":1110},"obj":"Chemical"},{"id":"T74616","span":{"begin":1166,"end":1172},"obj":"Chemical"},{"id":"T82226","span":{"begin":1181,"end":1183},"obj":"Chemical"}],"attributes":[{"id":"A3443","pred":"chebi_id","subj":"T66289","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A92464","pred":"chebi_id","subj":"T19025","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A66256","pred":"chebi_id","subj":"T38899","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A52134","pred":"chebi_id","subj":"T96153","obj":"http://purl.obolibrary.org/obo/CHEBI_3380"},{"id":"A50096","pred":"chebi_id","subj":"T96153","obj":"http://purl.obolibrary.org/obo/CHEBI_73461"},{"id":"A9916","pred":"chebi_id","subj":"T74616","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A78367","pred":"chebi_id","subj":"T82226","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"subj":"T66289","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T19025","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T38899","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T96153","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T74616","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T82226","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"773","span":{"begin":767,"end":771},"obj":"Gene"},{"id":"774","span":{"begin":1181,"end":1183},"obj":"Chemical"},{"id":"775","span":{"begin":1210,"end":1213},"obj":"Chemical"}],"attributes":[{"id":"A773","pred":"tao:has_database_id","subj":"773","obj":"Gene:10927"},{"id":"A775","pred":"tao:has_database_id","subj":"775","obj":"MESH:C000615229"},{"subj":"773","pred":"source","obj":"LitCovid-PubTator"},{"subj":"774","pred":"source","obj":"LitCovid-PubTator"},{"subj":"775","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T512","span":{"begin":0,"end":80},"obj":"Sentence"},{"id":"T513","span":{"begin":81,"end":176},"obj":"Sentence"},{"id":"T514","span":{"begin":177,"end":534},"obj":"Sentence"},{"id":"T515","span":{"begin":535,"end":720},"obj":"Sentence"},{"id":"T516","span":{"begin":721,"end":826},"obj":"Sentence"},{"id":"T517","span":{"begin":827,"end":945},"obj":"Sentence"},{"id":"T518","span":{"begin":946,"end":1037},"obj":"Sentence"},{"id":"T519","span":{"begin":1038,"end":1224},"obj":"Sentence"},{"id":"T520","span":{"begin":1225,"end":1302},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T512","pred":"source","obj":"LitCovid-sentences"},{"subj":"T513","pred":"source","obj":"LitCovid-sentences"},{"subj":"T514","pred":"source","obj":"LitCovid-sentences"},{"subj":"T515","pred":"source","obj":"LitCovid-sentences"},{"subj":"T516","pred":"source","obj":"LitCovid-sentences"},{"subj":"T517","pred":"source","obj":"LitCovid-sentences"},{"subj":"T518","pred":"source","obj":"LitCovid-sentences"},{"subj":"T519","pred":"source","obj":"LitCovid-sentences"},{"subj":"T520","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-CLO","color":"#c693ec","default":true},{"id":"LitCovid-PD-CHEBI","color":"#93ecac"},{"id":"LitCovid-PubTator","color":"#ec9393"},{"id":"LitCovid-sentences","color":"#93adec"}]}]}}