PMC:7594251 / 76003-76518 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T82421","span":{"begin":102,"end":110},"obj":"Body_part"},{"id":"T145","span":{"begin":274,"end":281},"obj":"Body_part"},{"id":"T146","span":{"begin":365,"end":373},"obj":"Body_part"},{"id":"T147","span":{"begin":403,"end":410},"obj":"Body_part"}],"attributes":[{"id":"A60632","pred":"fma_id","subj":"T82421","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A145","pred":"fma_id","subj":"T145","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A146","pred":"fma_id","subj":"T146","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A147","pred":"fma_id","subj":"T147","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"Through a series of extensive experiments, they showed that conformational exchange rates of membrane proteins can be determined from measurements of the metal-enhanced longitudinal relaxation (i.e., PRE) of the 19F nuclei [353], thus yielding additional information (i.e., protein conformation dynamics) that could be utilized in drug discovery projects targeting proteins (i.e., understanding how the protein changes shape based on its environment can be used to find potential binding sites for drug candidates)."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T535","span":{"begin":8,"end":9},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T536","span":{"begin":93,"end":101},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"}],"text":"Through a series of extensive experiments, they showed that conformational exchange rates of membrane proteins can be determined from measurements of the metal-enhanced longitudinal relaxation (i.e., PRE) of the 19F nuclei [353], thus yielding additional information (i.e., protein conformation dynamics) that could be utilized in drug discovery projects targeting proteins (i.e., understanding how the protein changes shape based on its environment can be used to find potential binding sites for drug candidates)."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T58004","span":{"begin":102,"end":110},"obj":"Chemical"},{"id":"T81893","span":{"begin":216,"end":222},"obj":"Chemical"},{"id":"T25408","span":{"begin":274,"end":281},"obj":"Chemical"},{"id":"T47208","span":{"begin":331,"end":335},"obj":"Chemical"},{"id":"T309","span":{"begin":365,"end":373},"obj":"Chemical"},{"id":"T30216","span":{"begin":403,"end":410},"obj":"Chemical"},{"id":"T311","span":{"begin":498,"end":502},"obj":"Chemical"}],"attributes":[{"id":"A62546","pred":"chebi_id","subj":"T58004","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A5193","pred":"chebi_id","subj":"T81893","obj":"http://purl.obolibrary.org/obo/CHEBI_33252"},{"id":"A44217","pred":"chebi_id","subj":"T25408","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A10140","pred":"chebi_id","subj":"T47208","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A17998","pred":"chebi_id","subj":"T309","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A40530","pred":"chebi_id","subj":"T30216","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A55915","pred":"chebi_id","subj":"T311","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"}],"text":"Through a series of extensive experiments, they showed that conformational exchange rates of membrane proteins can be determined from measurements of the metal-enhanced longitudinal relaxation (i.e., PRE) of the 19F nuclei [353], thus yielding additional information (i.e., protein conformation dynamics) that could be utilized in drug discovery projects targeting proteins (i.e., understanding how the protein changes shape based on its environment can be used to find potential binding sites for drug candidates)."}

{"project":"LitCovid-PubTator","denotations":[{"id":"763","span":{"begin":154,"end":159},"obj":"Chemical"}],"attributes":[{"id":"A763","pred":"tao:has_database_id","subj":"763","obj":"MESH:D008670"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Through a series of extensive experiments, they showed that conformational exchange rates of membrane proteins can be determined from measurements of the metal-enhanced longitudinal relaxation (i.e., PRE) of the 19F nuclei [353], thus yielding additional information (i.e., protein conformation dynamics) that could be utilized in drug discovery projects targeting proteins (i.e., understanding how the protein changes shape based on its environment can be used to find potential binding sites for drug candidates)."}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T68138","span":{"begin":75,"end":83},"obj":"http://purl.obolibrary.org/obo/GO_0015297"}],"text":"Through a series of extensive experiments, they showed that conformational exchange rates of membrane proteins can be determined from measurements of the metal-enhanced longitudinal relaxation (i.e., PRE) of the 19F nuclei [353], thus yielding additional information (i.e., protein conformation dynamics) that could be utilized in drug discovery projects targeting proteins (i.e., understanding how the protein changes shape based on its environment can be used to find potential binding sites for drug candidates)."}

{"project":"LitCovid-sentences","denotations":[{"id":"T503","span":{"begin":0,"end":515},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Through a series of extensive experiments, they showed that conformational exchange rates of membrane proteins can be determined from measurements of the metal-enhanced longitudinal relaxation (i.e., PRE) of the 19F nuclei [353], thus yielding additional information (i.e., protein conformation dynamics) that could be utilized in drug discovery projects targeting proteins (i.e., understanding how the protein changes shape based on its environment can be used to find potential binding sites for drug candidates)."}