> top > docs > PMC:7594251 > spans > 62794-64111 > annotations

PMC:7594251 / 62794-64111 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T35535 376-384 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T456 33-36 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T457 467-475 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeling
T458 588-595 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeled
T459 649-650 http://purl.obolibrary.org/obo/CLO_0001020 denotes A
T460 744-751 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T461 820-827 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T462 933-934 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T463 1212-1218 http://purl.obolibrary.org/obo/SO_0000418 denotes signal

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T134 51-57 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T58958 85-89 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T49808 206-212 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T13572 220-228 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T138 359-368 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T93907 376-384 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T95011 429-433 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T91115 735-743 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T6507 1098-1107 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T432 0-100 Sentence denotes Diffusion-based NMR spectroscopy has advantages in ligand based screening applied to drug discovery.
T433 101-235 Sentence denotes For example, Diffusion Ordered Spectroscopy (DOSY) does not require prior separation/purification of the ligand/target solution [298].
T434 236-648 Sentence denotes Diffusion based NMR allows simultaneous determination of diffusion coefficients in multicomponent systems containing large molecules (i.e., proteins) and possible binding partners (i.e., small drug compounds) [285], and no special labeling or contrasting agents are required, though their use is not exclusively inhibited (for an example of the use of labeled compounds in diffusion NMR spectroscopy, see [299]).
T435 649-767 Sentence denotes A problem occurs when there is significant chemical shift overlap between the binding molecule signals and the target.
T436 768-942 Sentence denotes This situation makes it hard to distinguish the NMR signals [300], and the calculations typically assign an intermediate value to the diffusion rate (i.e., one gets a smear).
T437 943-1075 Sentence denotes Multidimensional diffusion NMR pulse sequences are available [301], which may help resolve spectral overlap in 1D experiments [300].
T438 1076-1174 Sentence denotes Another issue is that molecules in chemical databases may have generally low solubility [302,303].
T439 1175-1317 Sentence denotes Low solubility decreases the overall signal intensity and therefore makes accurately measuring diffusion experiments far more difficult [304].