PMC:7594251 / 49361-50340 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T23445","span":{"begin":311,"end":318},"obj":"Body_part"}],"attributes":[{"id":"A77649","pred":"fma_id","subj":"T23445","obj":"http://purl.org/sig/ont/fma/fma67257"}],"text":"The very large size of viruses makes them particularly attractive for studies by STD NMR, as they inherently yield large line widths allowing for easy irradiation of the virus without affecting the ligand protons. Furthermore, because of the larger correlation time of a virus in comparison to an average-sized protein, spin diffusion, and thus saturation transfer, is very efficient. The large line width has additional benefits not just for STD-based NMR methods but also for transfer NOESY spectra, as protons from the virus capsid are invisible in the NMR spectra (for an example of a transfer NOESY spectrum, see [265]). Moreover, competitive STD titration experiments can be used to determine the Kd value of a ligand [271]. Analysis of the STD spectra using the group epitope mapping method [271] allows for the determination of the binding epitope. STD NMR methods can considerably speed up the determination of the binding epitope for potential antiviral lead compounds."}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T50","span":{"begin":81,"end":84},"obj":"Disease"},{"id":"T51","span":{"begin":443,"end":446},"obj":"Disease"},{"id":"T52","span":{"begin":648,"end":651},"obj":"Disease"},{"id":"T53","span":{"begin":747,"end":750},"obj":"Disease"},{"id":"T54","span":{"begin":857,"end":860},"obj":"Disease"}],"attributes":[{"id":"A50","pred":"mondo_id","subj":"T50","obj":"http://purl.obolibrary.org/obo/MONDO_0021681"},{"id":"A51","pred":"mondo_id","subj":"T51","obj":"http://purl.obolibrary.org/obo/MONDO_0021681"},{"id":"A52","pred":"mondo_id","subj":"T52","obj":"http://purl.obolibrary.org/obo/MONDO_0021681"},{"id":"A53","pred":"mondo_id","subj":"T53","obj":"http://purl.obolibrary.org/obo/MONDO_0021681"},{"id":"A54","pred":"mondo_id","subj":"T54","obj":"http://purl.obolibrary.org/obo/MONDO_0021681"}],"text":"The very large size of viruses makes them particularly attractive for studies by STD NMR, as they inherently yield large line widths allowing for easy irradiation of the virus without affecting the ligand protons. Furthermore, because of the larger correlation time of a virus in comparison to an average-sized protein, spin diffusion, and thus saturation transfer, is very efficient. The large line width has additional benefits not just for STD-based NMR methods but also for transfer NOESY spectra, as protons from the virus capsid are invisible in the NMR spectra (for an example of a transfer NOESY spectrum, see [265]). Moreover, competitive STD titration experiments can be used to determine the Kd value of a ligand [271]. Analysis of the STD spectra using the group epitope mapping method [271] allows for the determination of the binding epitope. STD NMR methods can considerably speed up the determination of the binding epitope for potential antiviral lead compounds."}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T343","span":{"begin":23,"end":30},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T344","span":{"begin":170,"end":175},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T345","span":{"begin":269,"end":270},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T346","span":{"begin":271,"end":276},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T347","span":{"begin":406,"end":409},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T348","span":{"begin":522,"end":527},"obj":"http://purl.obolibrary.org/obo/NCBITaxon_10239"},{"id":"T349","span":{"begin":587,"end":588},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T350","span":{"begin":715,"end":716},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"The very large size of viruses makes them particularly attractive for studies by STD NMR, as they inherently yield large line widths allowing for easy irradiation of the virus without affecting the ligand protons. Furthermore, because of the larger correlation time of a virus in comparison to an average-sized protein, spin diffusion, and thus saturation transfer, is very efficient. The large line width has additional benefits not just for STD-based NMR methods but also for transfer NOESY spectra, as protons from the virus capsid are invisible in the NMR spectra (for an example of a transfer NOESY spectrum, see [265]). Moreover, competitive STD titration experiments can be used to determine the Kd value of a ligand [271]. Analysis of the STD spectra using the group epitope mapping method [271] allows for the determination of the binding epitope. STD NMR methods can considerably speed up the determination of the binding epitope for potential antiviral lead compounds."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T37641","span":{"begin":198,"end":204},"obj":"Chemical"},{"id":"T34551","span":{"begin":311,"end":318},"obj":"Chemical"},{"id":"T65684","span":{"begin":717,"end":723},"obj":"Chemical"},{"id":"T791","span":{"begin":769,"end":774},"obj":"Chemical"},{"id":"T2014","span":{"begin":775,"end":782},"obj":"Chemical"},{"id":"T61404","span":{"begin":848,"end":855},"obj":"Chemical"},{"id":"T69224","span":{"begin":932,"end":939},"obj":"Chemical"},{"id":"T31144","span":{"begin":954,"end":963},"obj":"Chemical"},{"id":"T9","span":{"begin":964,"end":978},"obj":"Chemical"}],"attributes":[{"id":"A70815","pred":"chebi_id","subj":"T37641","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A95587","pred":"chebi_id","subj":"T34551","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A62448","pred":"chebi_id","subj":"T65684","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A81704","pred":"chebi_id","subj":"T791","obj":"http://purl.obolibrary.org/obo/CHEBI_24433"},{"id":"A46055","pred":"chebi_id","subj":"T2014","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A89326","pred":"chebi_id","subj":"T61404","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A50361","pred":"chebi_id","subj":"T69224","obj":"http://purl.obolibrary.org/obo/CHEBI_53000"},{"id":"A26305","pred":"chebi_id","subj":"T31144","obj":"http://purl.obolibrary.org/obo/CHEBI_22587"},{"id":"A49684","pred":"chebi_id","subj":"T9","obj":"http://purl.obolibrary.org/obo/CHEBI_33585"}],"text":"The very large size of viruses makes them particularly attractive for studies by STD NMR, as they inherently yield large line widths allowing for easy irradiation of the virus without affecting the ligand protons. Furthermore, because of the larger correlation time of a virus in comparison to an average-sized protein, spin diffusion, and thus saturation transfer, is very efficient. The large line width has additional benefits not just for STD-based NMR methods but also for transfer NOESY spectra, as protons from the virus capsid are invisible in the NMR spectra (for an example of a transfer NOESY spectrum, see [265]). Moreover, competitive STD titration experiments can be used to determine the Kd value of a ligand [271]. Analysis of the STD spectra using the group epitope mapping method [271] allows for the determination of the binding epitope. STD NMR methods can considerably speed up the determination of the binding epitope for potential antiviral lead compounds."}

{"project":"LitCovid-PubTator","denotations":[{"id":"595","span":{"begin":320,"end":324},"obj":"Gene"}],"attributes":[{"id":"A595","pred":"tao:has_database_id","subj":"595","obj":"Gene:10927"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"The very large size of viruses makes them particularly attractive for studies by STD NMR, as they inherently yield large line widths allowing for easy irradiation of the virus without affecting the ligand protons. Furthermore, because of the larger correlation time of a virus in comparison to an average-sized protein, spin diffusion, and thus saturation transfer, is very efficient. The large line width has additional benefits not just for STD-based NMR methods but also for transfer NOESY spectra, as protons from the virus capsid are invisible in the NMR spectra (for an example of a transfer NOESY spectrum, see [265]). Moreover, competitive STD titration experiments can be used to determine the Kd value of a ligand [271]. Analysis of the STD spectra using the group epitope mapping method [271] allows for the determination of the binding epitope. STD NMR methods can considerably speed up the determination of the binding epitope for potential antiviral lead compounds."}

{"project":"LitCovid-sentences","denotations":[{"id":"T342","span":{"begin":0,"end":213},"obj":"Sentence"},{"id":"T343","span":{"begin":214,"end":384},"obj":"Sentence"},{"id":"T344","span":{"begin":385,"end":625},"obj":"Sentence"},{"id":"T345","span":{"begin":626,"end":730},"obj":"Sentence"},{"id":"T346","span":{"begin":731,"end":856},"obj":"Sentence"},{"id":"T347","span":{"begin":857,"end":979},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The very large size of viruses makes them particularly attractive for studies by STD NMR, as they inherently yield large line widths allowing for easy irradiation of the virus without affecting the ligand protons. Furthermore, because of the larger correlation time of a virus in comparison to an average-sized protein, spin diffusion, and thus saturation transfer, is very efficient. The large line width has additional benefits not just for STD-based NMR methods but also for transfer NOESY spectra, as protons from the virus capsid are invisible in the NMR spectra (for an example of a transfer NOESY spectrum, see [265]). Moreover, competitive STD titration experiments can be used to determine the Kd value of a ligand [271]. Analysis of the STD spectra using the group epitope mapping method [271] allows for the determination of the binding epitope. STD NMR methods can considerably speed up the determination of the binding epitope for potential antiviral lead compounds."}