PMC:7594251 / 47967-49360
Annnotations
LitCovid-PD-FMA-UBERON
| Id | Subject | Object | Predicate | Lexical cue | fma_id |
|---|---|---|---|---|---|
| T62167 | 785-792 | Body_part | denotes | protein | http://purl.org/sig/ont/fma/fma67257 |
| T15931 | 915-923 | Body_part | denotes | proteins | http://purl.org/sig/ont/fma/fma67257 |
LitCovid-PD-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T46 | 219-222 | Disease | denotes | STD | http://purl.obolibrary.org/obo/MONDO_0021681 |
| T47 | 568-571 | Disease | denotes | STD | http://purl.obolibrary.org/obo/MONDO_0021681 |
| T48 | 607-610 | Disease | denotes | STD | http://purl.obolibrary.org/obo/MONDO_0021681 |
| T49 | 1173-1176 | Disease | denotes | STD | http://purl.obolibrary.org/obo/MONDO_0021681 |
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T332 | 112-115 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T333 | 347-352 | http://purl.obolibrary.org/obo/NCBITaxon_9606 | denotes | human |
| T334 | 487-494 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T335 | 500-501 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T336 | 769-777 | http://purl.obolibrary.org/obo/CLO_0001658 | denotes | activity |
| T337 | 803-806 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T338 | 949-954 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T339 | 1051-1056 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T340 | 1112-1119 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | viruses |
| T341 | 1220-1225 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
| T342 | 1338-1343 | http://purl.obolibrary.org/obo/NCBITaxon_10239 | denotes | virus |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T467 | 33-48 | Chemical | denotes | antiviral drugs | http://purl.obolibrary.org/obo/CHEBI_36044 |
| T468 | 33-42 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T469 | 43-48 | Chemical | denotes | drugs | http://purl.obolibrary.org/obo/CHEBI_23888 |
| T470 | 318-327 | Chemical | denotes | antiviral | http://purl.obolibrary.org/obo/CHEBI_22587 |
| T471 | 785-792 | Chemical | denotes | protein | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T472 | 889-896 | Chemical | denotes | ligands | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T473 | 915-923 | Chemical | denotes | proteins | http://purl.obolibrary.org/obo/CHEBI_36080 |
| T474 | 955-961 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
| T475 | 1158-1166 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
| T476 | 1344-1350 | Chemical | denotes | ligand | http://purl.obolibrary.org/obo/CHEBI_52214 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 591 | 347-363 | Species | denotes | human rhinovirus | Tax:169066 |
| 592 | 376-380 | Species | denotes | HRV2 | Tax:12130 |
| 593 | 514-518 | Species | denotes | HRV2 | Tax:12130 |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T334 | 0-146 | Sentence | denotes | With the pressing search for new antiviral drugs, any techniques for identifying and characterizing novel leads has become increasingly important. |
| T335 | 147-382 | Sentence | denotes | Benie et al. [265] described the use of saturation transfer difference (STD) NMR spectroscopy [262,266,267,268,269,270,271] to identify and characterize the binding of an antiviral compound to native human rhinovirus serotype 2 (HRV2). |
| T336 | 383-588 | Sentence | denotes | The experiments demonstrated that it is possible to subject targets of the size and complexity of whole viruses (for a model of an HRV2 particle cut open, cf. the table of contents) to STD NMR experiments. |
| T337 | 589-831 | Sentence | denotes | The principles of STD NMR have been known for many years [267,268] but it was only recently that the potential of this technique for screening libraries for compounds with binding activity toward protein receptors has been realized [262,266]. |
| T338 | 832-924 | Sentence | denotes | The technique also permitted the analysis of epitopes of ligands bound to receptor proteins. |
| T339 | 925-1057 | Sentence | denotes | Previous NMR studies of virus-ligand interactions used chemical shift titrations, which required very large quantities of the virus. |
| T340 | 1058-1120 | Sentence | denotes | This approach was unworkable when studying pathogenic viruses. |
| T341 | 1121-1393 | Sentence | denotes | Benie et al. [265] demonstrated that solution state STD methodology not only reduces the amount of virus required by approximately 2 orders of magnitude, but also allows for the identification and characterization of virus-ligand interactions with atomic resolution [272]. |