| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T29 |
0-185 |
Sentence |
denotes |
Compared to mass spectrometry and high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) is another powerful technique with several unique advantages [5,6,7,8]. |
| T30 |
186-386 |
Sentence |
denotes |
NMR is intrinsically quantitative, and it provides several different approaches that are routinely utilized to identify and structurally elucidate molecules of interest [9,10,11,12,13,14,15,16,17,18]. |
| T31 |
387-700 |
Sentence |
denotes |
In contrast to mass spectrometry, NMR is non-destructive, non-invasive, has extremely high reproducibility permitting researchers to acquire measurements under different experimental conditions (e.g., temperature, time points, and concentrations) often while the same sample is inside the magnet [19,20,21,22,23]. |
| T32 |
701-884 |
Sentence |
denotes |
NMR can be used in reaction kinetic studies while several consecutive measurements are taken, and while spectral changes (function of the reaction time) are analyzed [24,25,26,27,28]. |
| T33 |
885-948 |
Sentence |
denotes |
Moreover, molecules are studied at the atomic level [29,30,31]. |
| T34 |
949-1159 |
Sentence |
denotes |
Unlike other analytical tools, NMR provides dynamic information, and NMR experiments can be carried out under physiological conditions (e.g., atmospheric pressure, temperature, and different pH values) [32,33]. |
| T35 |
1160-1303 |
Sentence |
denotes |
This is especially important in medical drug design since one must understand the interactions between an enzyme of interest and the ligand(s). |
| T36 |
1304-1474 |
Sentence |
denotes |
NMR provides information on the binding affinity of such ligands, details/location of the binding site, and associated structural changes following binding [32,33,34,35]. |
| T37 |
1475-1604 |
Sentence |
denotes |
These biophysical details are essential when evaluating the potential efficacy of a drug, and during any subsequent optimization. |
| T38 |
1605-1702 |
Sentence |
denotes |
The available literature [32,33,34,36] highlights the practicality of NMR in drug design studies. |
| T39 |
1703-1918 |
Sentence |
denotes |
For these reasons, NMR spectroscopy is highly sought after in drug development [37,38,39,40,41], for both molecule identification [11,13,14,18,42,43,44,45,46] and structural elucidation [15,16,17,45,47,48,49,50,51]. |
| T40 |
1919-2134 |
Sentence |
denotes |
NMR has been successfully applied in stereochemistry [52,53,54,55,56] and isomer determination [57,58,59,60,61], in drug-protein interactions studies [62,63,64], and in the evaluation of drug toxicity [65,66,67,68]. |
