PMC:7594251 / 33385-34261 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/7594251","sourcedb":"PMC","sourceid":"7594251","source_url":"https://www.ncbi.nlm.nih.gov/pmc/7594251","text":"T1 relaxation times can be easily used to screen small molecules as ligands for DNA [165] and serve as a basis for HTS experiments [166]. An experiment related to drug design that utilized 1D and 2D relaxation edited NMR was done by Hajduk et al. [167] in which he and others used 1D and 2D relaxation edited NMR techniques to detect ligands that bind to FK506 binding protein and stromelysin. One year earlier, Liu et al. [157] used relaxation edited one-and two-dimensional 1H-NMR spectroscopy to characterize biological fluids. Tang et al. [168] extended this by applying relaxation edited NMR Spectroscopy to improve the detection of metabolites in blood plasma. More recently, Jaremko et al. commented on available models used to interpret 15N protein relaxation data [169], and even used deficient 15N relaxation data to rapidly calculate the dynamics of proteins [170].","tracks":[{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T39858","span":{"begin":80,"end":83},"obj":"Body_part"},{"id":"T62847","span":{"begin":369,"end":376},"obj":"Body_part"},{"id":"T88379","span":{"begin":653,"end":665},"obj":"Body_part"},{"id":"T40091","span":{"begin":749,"end":756},"obj":"Body_part"},{"id":"T37259","span":{"begin":861,"end":869},"obj":"Body_part"}],"attributes":[{"id":"A32034","pred":"fma_id","subj":"T39858","obj":"http://purl.org/sig/ont/fma/fma74412"},{"id":"A80965","pred":"fma_id","subj":"T62847","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A68817","pred":"fma_id","subj":"T88379","obj":"http://purl.org/sig/ont/fma/fma62970"},{"id":"A2320","pred":"fma_id","subj":"T40091","obj":"http://purl.org/sig/ont/fma/fma67257"},{"id":"A28521","pred":"fma_id","subj":"T37259","obj":"http://purl.org/sig/ont/fma/fma67257"},{"subj":"T39858","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T62847","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T88379","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T40091","pred":"source","obj":"LitCovid-PD-FMA-UBERON"},{"subj":"T37259","pred":"source","obj":"LitCovid-PD-FMA-UBERON"}]},{"project":"LitCovid-PD-UBERON","denotations":[{"id":"T21","span":{"begin":653,"end":665},"obj":"Body_part"},{"id":"T22","span":{"begin":653,"end":658},"obj":"Body_part"}],"attributes":[{"id":"A21","pred":"uberon_id","subj":"T21","obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"A22","pred":"uberon_id","subj":"T22","obj":"http://purl.obolibrary.org/obo/UBERON_0000178"},{"subj":"T21","pred":"source","obj":"LitCovid-PD-UBERON"},{"subj":"T22","pred":"source","obj":"LitCovid-PD-UBERON"}]},{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T19","span":{"begin":115,"end":118},"obj":"Disease"},{"id":"T20","span":{"begin":262,"end":264},"obj":"Disease"}],"attributes":[{"id":"A19","pred":"mondo_id","subj":"T19","obj":"http://purl.obolibrary.org/obo/MONDO_0011549"},{"id":"A20","pred":"mondo_id","subj":"T20","obj":"http://purl.obolibrary.org/obo/MONDO_0017319"},{"subj":"T19","pred":"source","obj":"LitCovid-PD-MONDO"},{"subj":"T20","pred":"source","obj":"LitCovid-PD-MONDO"}]},{"project":"LitCovid-PD-CLO","denotations":[{"id":"T87448","span":{"begin":103,"end":104},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T90168","span":{"begin":653,"end":665},"obj":"http://purl.obolibrary.org/obo/UBERON_0001969"}],"attributes":[{"subj":"T87448","pred":"source","obj":"LitCovid-PD-CLO"},{"subj":"T90168","pred":"source","obj":"LitCovid-PD-CLO"}]},{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T325","span":{"begin":55,"end":64},"obj":"Chemical"},{"id":"T326","span":{"begin":68,"end":75},"obj":"Chemical"},{"id":"T327","span":{"begin":80,"end":83},"obj":"Chemical"},{"id":"T328","span":{"begin":163,"end":167},"obj":"Chemical"},{"id":"T329","span":{"begin":334,"end":341},"obj":"Chemical"},{"id":"T330","span":{"begin":355,"end":360},"obj":"Chemical"},{"id":"T331","span":{"begin":369,"end":376},"obj":"Chemical"},{"id":"T332","span":{"begin":476,"end":478},"obj":"Chemical"},{"id":"T333","span":{"begin":638,"end":649},"obj":"Chemical"},{"id":"T334","span":{"begin":749,"end":756},"obj":"Chemical"},{"id":"T335","span":{"begin":861,"end":869},"obj":"Chemical"}],"attributes":[{"id":"A325","pred":"chebi_id","subj":"T325","obj":"http://purl.obolibrary.org/obo/CHEBI_25367"},{"id":"A326","pred":"chebi_id","subj":"T326","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A327","pred":"chebi_id","subj":"T327","obj":"http://purl.obolibrary.org/obo/CHEBI_16991"},{"id":"A328","pred":"chebi_id","subj":"T328","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A329","pred":"chebi_id","subj":"T329","obj":"http://purl.obolibrary.org/obo/CHEBI_52214"},{"id":"A330","pred":"chebi_id","subj":"T330","obj":"http://purl.obolibrary.org/obo/CHEBI_61049"},{"id":"A331","pred":"chebi_id","subj":"T331","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A332","pred":"chebi_id","subj":"T332","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A333","pred":"chebi_id","subj":"T333","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A334","pred":"chebi_id","subj":"T334","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"id":"A335","pred":"chebi_id","subj":"T335","obj":"http://purl.obolibrary.org/obo/CHEBI_36080"},{"subj":"T325","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T326","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T327","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T328","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T329","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T330","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T331","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T332","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T333","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T334","pred":"source","obj":"LitCovid-PD-CHEBI"},{"subj":"T335","pred":"source","obj":"LitCovid-PD-CHEBI"}]},{"project":"LitCovid-PubTator","denotations":[{"id":"495","span":{"begin":189,"end":191},"obj":"Chemical"},{"id":"496","span":{"begin":196,"end":198},"obj":"Chemical"},{"id":"497","span":{"begin":281,"end":283},"obj":"Chemical"},{"id":"498","span":{"begin":355,"end":360},"obj":"Chemical"},{"id":"499","span":{"begin":476,"end":478},"obj":"Chemical"},{"id":"500","span":{"begin":745,"end":748},"obj":"Chemical"},{"id":"501","span":{"begin":804,"end":807},"obj":"Chemical"}],"attributes":[{"id":"A498","pred":"tao:has_database_id","subj":"498","obj":"MESH:D016559"},{"subj":"495","pred":"source","obj":"LitCovid-PubTator"},{"subj":"496","pred":"source","obj":"LitCovid-PubTator"},{"subj":"497","pred":"source","obj":"LitCovid-PubTator"},{"subj":"498","pred":"source","obj":"LitCovid-PubTator"},{"subj":"499","pred":"source","obj":"LitCovid-PubTator"},{"subj":"500","pred":"source","obj":"LitCovid-PubTator"},{"subj":"501","pred":"source","obj":"LitCovid-PubTator"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}]},{"project":"LitCovid-sentences","denotations":[{"id":"T232","span":{"begin":0,"end":137},"obj":"Sentence"},{"id":"T233","span":{"begin":138,"end":393},"obj":"Sentence"},{"id":"T234","span":{"begin":394,"end":530},"obj":"Sentence"},{"id":"T235","span":{"begin":531,"end":666},"obj":"Sentence"},{"id":"T236","span":{"begin":667,"end":876},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"T232","pred":"source","obj":"LitCovid-sentences"},{"subj":"T233","pred":"source","obj":"LitCovid-sentences"},{"subj":"T234","pred":"source","obj":"LitCovid-sentences"},{"subj":"T235","pred":"source","obj":"LitCovid-sentences"},{"subj":"T236","pred":"source","obj":"LitCovid-sentences"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCovid-PD-FMA-UBERON","color":"#93bcec","default":true},{"id":"LitCovid-PD-UBERON","color":"#d6ec93"},{"id":"LitCovid-PD-MONDO","color":"#e893ec"},{"id":"LitCovid-PD-CLO","color":"#93ecce"},{"id":"LitCovid-PD-CHEBI","color":"#ecb493"},{"id":"LitCovid-PubTator","color":"#9a93ec"},{"id":"LitCovid-sentences","color":"#a5ec93"}]}]}}