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PMC:7594251 / 28864-30975 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T68385 401-409 Body_part denotes backbone http://purl.org/sig/ont/fma/fma13478
T68513 413-421 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T30146 1489-1494 Body_part denotes serum http://purl.org/sig/ont/fma/fma63083
T11099 1496-1502 Body_part denotes kidney http://purl.org/sig/ont/fma/fma7203
T30625 1508-1513 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197
T37089 1514-1520 Body_part denotes tissue http://purl.org/sig/ont/fma/fma9637
T93967 2007-2017 Body_part denotes amino acid http://purl.org/sig/ont/fma/fma82739
T77772 2034-2039 Body_part denotes lipid http://purl.org/sig/ont/fma/fma67264
T43843 2093-2100 Body_part denotes kidneys http://purl.org/sig/ont/fma/fma7203
T96240 2105-2110 Body_part denotes liver http://purl.org/sig/ont/fma/fma7197

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T16 1489-1494 Body_part denotes serum http://purl.obolibrary.org/obo/UBERON_0001977
T17 1496-1502 Body_part denotes kidney http://purl.obolibrary.org/obo/UBERON_0002113
T18 1508-1513 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T19 1514-1520 Body_part denotes tissue http://purl.obolibrary.org/obo/UBERON_0000479
T20 2105-2110 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T18 1333-1335 Disease denotes HD http://purl.obolibrary.org/obo/MONDO_0007739

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T84214 423-426 http://purl.obolibrary.org/obo/CLO_0001079 denotes 148
T6479 600-601 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20389 943-944 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T21966 1098-1099 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T74078 1294-1296 http://purl.obolibrary.org/obo/CLO_0007622 denotes MD
T25528 1359-1360 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T81398 1496-1502 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
T40369 1496-1502 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidney
T23231 1496-1502 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidney
T2572 1508-1513 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T95714 1508-1513 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver
T49055 1702-1709 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T39599 1946-1947 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T14589 2093-2100 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidneys
T43132 2093-2100 http://www.ebi.ac.uk/efo/EFO_0000927 denotes kidneys
T76931 2093-2100 http://www.ebi.ac.uk/efo/EFO_0000929 denotes kidneys
T29795 2105-2110 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
T14410 2105-2110 http://www.ebi.ac.uk/efo/EFO_0000887 denotes liver

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T274 10-12 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T275 109-115 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T276 123-125 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T277 145-151 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T278 351-357 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T279 413-421 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T280 435-446 Chemical denotes metabolites http://purl.obolibrary.org/obo/CHEBI_25212
T281 484-486 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T282 664-670 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T283 857-866 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T284 870-874 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T285 1120-1128 Chemical denotes medicine http://purl.obolibrary.org/obo/CHEBI_23888
T286 1247-1252 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T287 1254-1256 Chemical denotes LD http://purl.obolibrary.org/obo/CHEBI_74332
T288 1287-1292 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T289 1294-1296 Chemical denotes MD http://purl.obolibrary.org/obo/CHEBI_74699
T290 1326-1331 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T291 1333-1335 Chemical denotes HD http://purl.obolibrary.org/obo/CHEBI_73925
T292 1369-1374 Chemical denotes group http://purl.obolibrary.org/obo/CHEBI_24433
T293 1658-1660 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T294 1722-1731 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T295 1769-1771 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T296 1772-1774 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T297 1781-1783 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T298 1798-1800 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T299 1819-1828 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T300 1912-1923 Chemical denotes metabolites http://purl.obolibrary.org/obo/CHEBI_25212
T301 2007-2017 Chemical denotes amino acid http://purl.obolibrary.org/obo/CHEBI_33709
T302 2007-2012 Chemical denotes amino http://purl.obolibrary.org/obo/CHEBI_46882
T303 2013-2017 Chemical denotes acid http://purl.obolibrary.org/obo/CHEBI_37527
T304 2034-2039 Chemical denotes lipid http://purl.obolibrary.org/obo/CHEBI_18059

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
444 10-12 Chemical denotes 1H
445 14-17 Chemical denotes 13C MESH:C000615229
449 123-125 Chemical denotes 1H
450 159-162 Chemical denotes 13C MESH:C000615229
451 484-486 Chemical denotes 1H
467 1895-1899 Gene denotes pill Gene:8319132
468 1316-1320 Gene denotes high Gene:104137
469 1032-1036 Species denotes rats Tax:10116
470 1149-1153 Species denotes rats Tax:10116
471 1438-1441 Species denotes rat Tax:10116
472 1092-1096 Gene denotes pill Gene:8319132
473 1658-1660 Chemical denotes 1H
474 1769-1771 Chemical denotes 1H
475 1772-1774 Chemical denotes 1H
476 1781-1783 Chemical denotes 1H
477 1784-1787 Chemical denotes 13C MESH:C000615229
478 1798-1800 Chemical denotes 1H
479 1801-1804 Chemical denotes 13C MESH:C000615229
480 2034-2039 Chemical denotes lipid MESH:D008055
481 1333-1335 Disease denotes HD MESH:D006816

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T71924 1995-2005 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T68745 2018-2028 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T3745 2034-2050 http://purl.obolibrary.org/obo/GO_0006629 denotes lipid metabolism
T18679 2040-2050 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T202 0-6 Sentence denotes 2.2.4.
T203 7-22 Sentence denotes 2D 1H, 13C-HMBC
T204 23-240 Sentence denotes Heteronuclear 2D experiments are useful for transferring magnetization from sensitive nuclei (i.e., 1H) to less sensitive nuclei (i.e., 13C) [146] thereby reducing the time needed for the acquisition of spectra [147].
T205 241-358 Sentence denotes Heteronuclear Single Quantum Coherence (HSQC) will only show one cross peak for each coupled pair [92,128] of nuclei.
T206 359-539 Sentence denotes This makes HSQCs useful for assigning the backbone of proteins [148] and in metabolites of complex biofluids [149], whose 1D 1H-NMR spectra can suffer from severe spectral overlap.
T207 540-773 Sentence denotes The HMBC technique, while similar to HSQC, is an example of a heteronuclear 2D experiment that reveals correlations between nuclei separated by two or more chemical bonds while also suppressing one-bond correlations at the same time.
T208 774-910 Sentence denotes This experiment combined with HSQC is often used to assign NMR spectra for studied molecules in drug design experiments [65,66,137,145].
T209 911-1129 Sentence denotes As an example, HMBC was used in a recent study by Xu et al. [66] to investigate the changes in the metabolic profiles of rats treated with different dosages of the “RenqingMangjue” pill, a traditional Tibetan medicine.
T210 1130-1380 Sentence denotes In this study, the rats were divided into four groups based on the amount of “RenqingMangjue” administered: low dose group (LD)-83.33 mg/kg/day, middle dose group (MD)-333.33 mg/kg/day, high dose group (HD)-1333.33 mg/kg/day and a control group (NC).
T211 1381-1625 Sentence denotes After 15 days of consecutive administration, half of the rat population was used to collect samples such as serum, kidney, and liver tissue, while the other half underwent an additional 15 days of recovery before the same samples were acquired.
T212 1626-1840 Sentence denotes The samples were measured using 1H-NMR CPMG (an experiment used to suppress signals from larger molecules, see below) [150,151,152] along with 1H,1H-COSY, 1H,13C-HSQC, and 1H,13C-HMBC used for molecules assignment.
T213 1841-2111 Sentence denotes The obtained spectra showed that the “RenqingMangjue” pill alters many metabolites, which are related to a variety of metabolic pathways including energy metabolism, amino acid metabolism, and lipid metabolism indicating potentially harmful effects on kidneys and liver.