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LitCovid-PD-FMA-UBERON

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T65570","span":{"begin":150,"end":155},"obj":"Body_part"},{"id":"T64417","span":{"begin":259,"end":264},"obj":"Body_part"},{"id":"T30907","span":{"begin":478,"end":483},"obj":"Body_part"},{"id":"T71500","span":{"begin":550,"end":555},"obj":"Body_part"},{"id":"T7498","span":{"begin":611,"end":616},"obj":"Body_part"},{"id":"T49050","span":{"begin":694,"end":699},"obj":"Body_part"},{"id":"T73203","span":{"begin":741,"end":746},"obj":"Body_part"},{"id":"T75762","span":{"begin":912,"end":917},"obj":"Body_part"}],"attributes":[{"id":"A99729","pred":"fma_id","subj":"T65570","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A17284","pred":"fma_id","subj":"T64417","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A12800","pred":"fma_id","subj":"T30907","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A28917","pred":"fma_id","subj":"T71500","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A60200","pred":"fma_id","subj":"T7498","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A72215","pred":"fma_id","subj":"T49050","obj":"http://purl.org/sig/ont/fma/fma67264"},{"id":"A55959","pred":"fma_id","subj":"T73203","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A95490","pred":"fma_id","subj":"T75762","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"For example, De Castro et al. [145] studied Ptac2S and its related cytotoxicity to the cisplatin-resistant epithelial ovarian carcinoma (EOC), Skov-3 cells. In the study, they used NMR spectroscopy and multi-variate statistical analysis to observe how Skov-3 cells reacted to treatment with Ptac2S. In particular, they used 1H,13C-HSQC along with 1H-COSY and Heteronuclear Multiple Bond Correlation (HMBC), and the Human Metabolome Database to assign the chemical shifts of the lipid metabolites present in the studied samples. Interestingly, Skov-3 cells treated with Ptac2S produced more pyruvate than Skov-3 cells treated with cisplatin. The authors also noticed an unexpected difference in lipid metabolite expression levels between the cells treated with Ptac2S and those treated with cisplatin. These results provide a possible explanation for how Ptac2S is able to overcome cisplatin resistance in Skov-3 cells [145]."}

LitCovid-PD-MONDO

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T16","span":{"begin":118,"end":135},"obj":"Disease"},{"id":"T17","span":{"begin":126,"end":135},"obj":"Disease"}],"attributes":[{"id":"A16","pred":"mondo_id","subj":"T16","obj":"http://purl.obolibrary.org/obo/MONDO_0005140"},{"id":"A17","pred":"mondo_id","subj":"T17","obj":"http://purl.obolibrary.org/obo/MONDO_0004993"}],"text":"For example, De Castro et al. [145] studied Ptac2S and its related cytotoxicity to the cisplatin-resistant epithelial ovarian carcinoma (EOC), Skov-3 cells. In the study, they used NMR spectroscopy and multi-variate statistical analysis to observe how Skov-3 cells reacted to treatment with Ptac2S. In particular, they used 1H,13C-HSQC along with 1H-COSY and Heteronuclear Multiple Bond Correlation (HMBC), and the Human Metabolome Database to assign the chemical shifts of the lipid metabolites present in the studied samples. Interestingly, Skov-3 cells treated with Ptac2S produced more pyruvate than Skov-3 cells treated with cisplatin. The authors also noticed an unexpected difference in lipid metabolite expression levels between the cells treated with Ptac2S and those treated with cisplatin. These results provide a possible explanation for how Ptac2S is able to overcome cisplatin resistance in Skov-3 cells [145]."}

LitCovid-PD-CLO

LitCovid-PD-CHEBI

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T263","span":{"begin":87,"end":96},"obj":"Chemical"},{"id":"T264","span":{"begin":324,"end":326},"obj":"Chemical"},{"id":"T265","span":{"begin":347,"end":349},"obj":"Chemical"},{"id":"T266","span":{"begin":478,"end":483},"obj":"Chemical"},{"id":"T267","span":{"begin":484,"end":495},"obj":"Chemical"},{"id":"T268","span":{"begin":590,"end":598},"obj":"Chemical"},{"id":"T269","span":{"begin":630,"end":639},"obj":"Chemical"},{"id":"T270","span":{"begin":694,"end":699},"obj":"Chemical"},{"id":"T271","span":{"begin":700,"end":710},"obj":"Chemical"},{"id":"T272","span":{"begin":790,"end":799},"obj":"Chemical"},{"id":"T273","span":{"begin":881,"end":890},"obj":"Chemical"}],"attributes":[{"id":"A263","pred":"chebi_id","subj":"T263","obj":"http://purl.obolibrary.org/obo/CHEBI_27899"},{"id":"A264","pred":"chebi_id","subj":"T264","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A265","pred":"chebi_id","subj":"T265","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A266","pred":"chebi_id","subj":"T266","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A267","pred":"chebi_id","subj":"T267","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A268","pred":"chebi_id","subj":"T268","obj":"http://purl.obolibrary.org/obo/CHEBI_15361"},{"id":"A269","pred":"chebi_id","subj":"T269","obj":"http://purl.obolibrary.org/obo/CHEBI_27899"},{"id":"A270","pred":"chebi_id","subj":"T270","obj":"http://purl.obolibrary.org/obo/CHEBI_18059"},{"id":"A271","pred":"chebi_id","subj":"T271","obj":"http://purl.obolibrary.org/obo/CHEBI_25212"},{"id":"A272","pred":"chebi_id","subj":"T272","obj":"http://purl.obolibrary.org/obo/CHEBI_27899"},{"id":"A273","pred":"chebi_id","subj":"T273","obj":"http://purl.obolibrary.org/obo/CHEBI_27899"}],"text":"For example, De Castro et al. [145] studied Ptac2S and its related cytotoxicity to the cisplatin-resistant epithelial ovarian carcinoma (EOC), Skov-3 cells. In the study, they used NMR spectroscopy and multi-variate statistical analysis to observe how Skov-3 cells reacted to treatment with Ptac2S. In particular, they used 1H,13C-HSQC along with 1H-COSY and Heteronuclear Multiple Bond Correlation (HMBC), and the Human Metabolome Database to assign the chemical shifts of the lipid metabolites present in the studied samples. Interestingly, Skov-3 cells treated with Ptac2S produced more pyruvate than Skov-3 cells treated with cisplatin. The authors also noticed an unexpected difference in lipid metabolite expression levels between the cells treated with Ptac2S and those treated with cisplatin. These results provide a possible explanation for how Ptac2S is able to overcome cisplatin resistance in Skov-3 cells [145]."}

LitCovid-PubTator

{"project":"LitCovid-PubTator","denotations":[{"id":"425","span":{"begin":415,"end":420},"obj":"Species"},{"id":"426","span":{"begin":87,"end":96},"obj":"Chemical"},{"id":"427","span":{"begin":291,"end":297},"obj":"Chemical"},{"id":"428","span":{"begin":324,"end":326},"obj":"Chemical"},{"id":"429","span":{"begin":327,"end":330},"obj":"Chemical"},{"id":"430","span":{"begin":347,"end":349},"obj":"Chemical"},{"id":"431","span":{"begin":478,"end":483},"obj":"Chemical"},{"id":"432","span":{"begin":569,"end":575},"obj":"Chemical"},{"id":"433","span":{"begin":590,"end":598},"obj":"Chemical"},{"id":"434","span":{"begin":630,"end":639},"obj":"Chemical"},{"id":"435","span":{"begin":694,"end":699},"obj":"Chemical"},{"id":"436","span":{"begin":760,"end":766},"obj":"Chemical"},{"id":"437","span":{"begin":790,"end":799},"obj":"Chemical"},{"id":"438","span":{"begin":854,"end":860},"obj":"Chemical"},{"id":"439","span":{"begin":881,"end":890},"obj":"Chemical"},{"id":"440","span":{"begin":67,"end":79},"obj":"Disease"},{"id":"441","span":{"begin":107,"end":135},"obj":"Disease"}],"attributes":[{"id":"A425","pred":"tao:has_database_id","subj":"425","obj":"Tax:9606"},{"id":"A426","pred":"tao:has_database_id","subj":"426","obj":"MESH:D002945"},{"id":"A429","pred":"tao:has_database_id","subj":"429","obj":"MESH:C000615229"},{"id":"A431","pred":"tao:has_database_id","subj":"431","obj":"MESH:D008055"},{"id":"A433","pred":"tao:has_database_id","subj":"433","obj":"MESH:D019289"},{"id":"A434","pred":"tao:has_database_id","subj":"434","obj":"MESH:D002945"},{"id":"A435","pred":"tao:has_database_id","subj":"435","obj":"MESH:D008055"},{"id":"A437","pred":"tao:has_database_id","subj":"437","obj":"MESH:D002945"},{"id":"A439","pred":"tao:has_database_id","subj":"439","obj":"MESH:D002945"},{"id":"A440","pred":"tao:has_database_id","subj":"440","obj":"MESH:D064420"},{"id":"A441","pred":"tao:has_database_id","subj":"441","obj":"MESH:D010051"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"For example, De Castro et al. [145] studied Ptac2S and its related cytotoxicity to the cisplatin-resistant epithelial ovarian carcinoma (EOC), Skov-3 cells. In the study, they used NMR spectroscopy and multi-variate statistical analysis to observe how Skov-3 cells reacted to treatment with Ptac2S. In particular, they used 1H,13C-HSQC along with 1H-COSY and Heteronuclear Multiple Bond Correlation (HMBC), and the Human Metabolome Database to assign the chemical shifts of the lipid metabolites present in the studied samples. Interestingly, Skov-3 cells treated with Ptac2S produced more pyruvate than Skov-3 cells treated with cisplatin. The authors also noticed an unexpected difference in lipid metabolite expression levels between the cells treated with Ptac2S and those treated with cisplatin. These results provide a possible explanation for how Ptac2S is able to overcome cisplatin resistance in Skov-3 cells [145]."}

LitCovid-PD-HP

{"project":"LitCovid-PD-HP","denotations":[{"id":"T7","span":{"begin":118,"end":135},"obj":"Phenotype"}],"attributes":[{"id":"A7","pred":"hp_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/HP_0025318"}],"text":"For example, De Castro et al. [145] studied Ptac2S and its related cytotoxicity to the cisplatin-resistant epithelial ovarian carcinoma (EOC), Skov-3 cells. In the study, they used NMR spectroscopy and multi-variate statistical analysis to observe how Skov-3 cells reacted to treatment with Ptac2S. In particular, they used 1H,13C-HSQC along with 1H-COSY and Heteronuclear Multiple Bond Correlation (HMBC), and the Human Metabolome Database to assign the chemical shifts of the lipid metabolites present in the studied samples. Interestingly, Skov-3 cells treated with Ptac2S produced more pyruvate than Skov-3 cells treated with cisplatin. The authors also noticed an unexpected difference in lipid metabolite expression levels between the cells treated with Ptac2S and those treated with cisplatin. These results provide a possible explanation for how Ptac2S is able to overcome cisplatin resistance in Skov-3 cells [145]."}

LitCovid-sentences

{"project":"LitCovid-sentences","denotations":[{"id":"T196","span":{"begin":0,"end":156},"obj":"Sentence"},{"id":"T197","span":{"begin":157,"end":298},"obj":"Sentence"},{"id":"T198","span":{"begin":299,"end":527},"obj":"Sentence"},{"id":"T199","span":{"begin":528,"end":640},"obj":"Sentence"},{"id":"T200","span":{"begin":641,"end":800},"obj":"Sentence"},{"id":"T201","span":{"begin":801,"end":924},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"For example, De Castro et al. [145] studied Ptac2S and its related cytotoxicity to the cisplatin-resistant epithelial ovarian carcinoma (EOC), Skov-3 cells. In the study, they used NMR spectroscopy and multi-variate statistical analysis to observe how Skov-3 cells reacted to treatment with Ptac2S. In particular, they used 1H,13C-HSQC along with 1H-COSY and Heteronuclear Multiple Bond Correlation (HMBC), and the Human Metabolome Database to assign the chemical shifts of the lipid metabolites present in the studied samples. Interestingly, Skov-3 cells treated with Ptac2S produced more pyruvate than Skov-3 cells treated with cisplatin. The authors also noticed an unexpected difference in lipid metabolite expression levels between the cells treated with Ptac2S and those treated with cisplatin. These results provide a possible explanation for how Ptac2S is able to overcome cisplatin resistance in Skov-3 cells [145]."}