PMC:7594251 / 21395-23877
Annnotations
LitCovid-PD-FMA-UBERON
Id | Subject | Object | Predicate | Lexical cue | fma_id |
---|---|---|---|---|---|
T47161 | 1808-1813 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
T51661 | 1895-1900 | Body_part | denotes | serum | http://purl.org/sig/ont/fma/fma63083 |
T25681 | 1905-1910 | Body_part | denotes | urine | http://purl.org/sig/ont/fma/fma12274 |
T23891 | 2436-2441 | Body_part | denotes | blood | http://purl.org/sig/ont/fma/fma9670 |
LitCovid-PD-UBERON
Id | Subject | Object | Predicate | Lexical cue | uberon_id |
---|---|---|---|---|---|
T6 | 1808-1813 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
T7 | 1895-1900 | Body_part | denotes | serum | http://purl.obolibrary.org/obo/UBERON_0001977 |
T8 | 1905-1910 | Body_part | denotes | urine | http://purl.obolibrary.org/obo/UBERON_0001088 |
T9 | 2436-2441 | Body_part | denotes | blood | http://purl.obolibrary.org/obo/UBERON_0000178 |
LitCovid-PD-CLO
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T17528 | 210-211 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T92439 | 245-246 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T83859 | 277-278 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T91246 | 305-306 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T69709 | 327-329 | http://purl.obolibrary.org/obo/CLO_0050160 | denotes | t2 |
T91898 | 414-416 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
T92124 | 509-511 | http://purl.obolibrary.org/obo/CLO_0053799 | denotes | 45 |
T26137 | 559-560 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | A |
T63635 | 596-598 | http://purl.obolibrary.org/obo/CLO_0003401 | denotes | FT |
T78725 | 1453-1454 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T76502 | 1465-1468 | http://purl.obolibrary.org/obo/CLO_0054061 | denotes | 132 |
T42866 | 1808-1813 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T98943 | 1808-1813 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
T84919 | 2159-2161 | http://purl.obolibrary.org/obo/CLO_0050510 | denotes | 18 |
T56516 | 2261-2262 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
T86496 | 2436-2441 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
T59085 | 2436-2441 | http://www.ebi.ac.uk/efo/EFO_0000296 | denotes | blood |
LitCovid-PD-CHEBI
Id | Subject | Object | Predicate | Lexical cue | chebi_id |
---|---|---|---|---|---|
T189 | 115-121 | Chemical | denotes | nuclei | http://purl.obolibrary.org/obo/CHEBI_33252 |
T190 | 129-131 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T191 | 132-134 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T192 | 585-594 | Chemical | denotes | Transform | http://purl.obolibrary.org/obo/CHEBI_133305 |
T193 | 596-598 | Chemical | denotes | FT | http://purl.obolibrary.org/obo/CHEBI_73636 |
T194 | 655-661 | Chemical | denotes | proton | http://purl.obolibrary.org/obo/CHEBI_24636 |
T195 | 663-665 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T196 | 670-676 | Chemical | denotes | carbon | http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415 |
T198 | 693-699 | Chemical | denotes | carbon | http://purl.obolibrary.org/obo/CHEBI_27594|http://purl.obolibrary.org/obo/CHEBI_33415 |
T200 | 841-843 | Chemical | denotes | II | http://purl.obolibrary.org/obo/CHEBI_74067 |
T201 | 1067-1073 | Chemical | denotes | nuclei | http://purl.obolibrary.org/obo/CHEBI_33252 |
T202 | 1150-1155 | Chemical | denotes | atoms | http://purl.obolibrary.org/obo/CHEBI_33250 |
T203 | 1227-1236 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T204 | 1249-1258 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
T205 | 1262-1270 | Chemical | denotes | solution | http://purl.obolibrary.org/obo/CHEBI_75958 |
T206 | 1455-1463 | Chemical | denotes | molecule | http://purl.obolibrary.org/obo/CHEBI_25367 |
T207 | 1712-1716 | Chemical | denotes | drug | http://purl.obolibrary.org/obo/CHEBI_23888 |
T208 | 1745-1753 | Chemical | denotes | medicine | http://purl.obolibrary.org/obo/CHEBI_23888 |
T209 | 1950-1952 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T210 | 1963-1965 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T211 | 1982-1984 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T212 | 1985-1987 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T213 | 1998-2000 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
T214 | 2172-2183 | Chemical | denotes | metabolites | http://purl.obolibrary.org/obo/CHEBI_25212 |
T215 | 2193-2200 | Chemical | denotes | lactate | http://purl.obolibrary.org/obo/CHEBI_24996 |
T216 | 2202-2214 | Chemical | denotes | nicotinamide | http://purl.obolibrary.org/obo/CHEBI_17154 |
T217 | 2216-2224 | Chemical | denotes | glycerol | http://purl.obolibrary.org/obo/CHEBI_17754 |
T218 | 2229-2236 | Chemical | denotes | formate | http://purl.obolibrary.org/obo/CHEBI_15740|http://purl.obolibrary.org/obo/CHEBI_52343 |
LitCovid-PubTator
Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
---|---|---|---|---|---|
282 | 1825-1829 | Species | denotes | rats | Tax:10116 |
283 | 2066-2070 | Species | denotes | rats | Tax:10116 |
284 | 129-131 | Chemical | denotes | 1H | |
285 | 132-134 | Chemical | denotes | 1H | |
286 | 663-665 | Chemical | denotes | 1H | |
287 | 670-676 | Chemical | denotes | carbon | MESH:D002244 |
288 | 693-699 | Chemical | denotes | carbon | MESH:D002244 |
289 | 1950-1952 | Chemical | denotes | 1H | |
290 | 1963-1965 | Chemical | denotes | 1H | |
291 | 1982-1984 | Chemical | denotes | 1H | |
292 | 1985-1987 | Chemical | denotes | 1H | |
293 | 1998-2000 | Chemical | denotes | 1H | |
294 | 2001-2004 | Chemical | denotes | 13C | MESH:C000615229 |
295 | 2193-2200 | Chemical | denotes | lactate | MESH:D019344 |
296 | 2202-2214 | Chemical | denotes | nicotinamide | MESH:D009536 |
297 | 2216-2224 | Chemical | denotes | glycerol | MESH:D005990 |
298 | 2229-2236 | Chemical | denotes | formate | MESH:C030544 |
299 | 1808-1824 | Disease | denotes | blood deficiency | MESH:D007022 |
LitCovid-PD-GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T44461 | 2288-2298 | http://purl.obolibrary.org/obo/GO_0008152 | denotes | metabolism |
LitCovid-sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T154 | 0-77 | Sentence | denotes | COSY is one of the simplest and most frequently used 2D NMR experiment [123]. |
T155 | 78-178 | Sentence | denotes | It shows the homonuclear coupling of nuclei (i.e., 1H-1H) separated by up to several covalent bonds. |
T156 | 179-382 | Sentence | denotes | The pulse sequence consists of a 90° excitation pulse followed by a specific evolution time (t1), a second pulse, and finally a measurement period (t2, not to be confused with relaxation rates or times). |
T157 | 383-558 | Sentence | denotes | The second pulse can be 90° or 45° or 135°, depending upon the specific requirements, and respectively yield COSY [124], COSY-45 or COSY-135 functionality (see [125,126,127]). |
T158 | 559-727 | Sentence | denotes | A two-dimensional Fourier Transform (FT) yields the final spectra and shows the frequencies for proton (1H) or carbon (in the case of carbon detection) along both axes. |
T159 | 728-947 | Sentence | denotes | There are two types of peaks; (I) Diagonal peaks, which represent the peaks of the conventional 1D spectra, and (II) cross-peaks, which have different values in the two frequency axes and are therefore off the diagonal. |
T160 | 948-1117 | Sentence | denotes | These off diagonal cross-peaks are the most important pieces of information as they mark correlations between pairs of nuclei due to through bond magnetization transfer. |
T161 | 1118-1277 | Sentence | denotes | This helps in identifying which atoms are connected [128], critical for structural elucidation of both known molecules and unknown molecules in solution [129]. |
T162 | 1278-1470 | Sentence | denotes | By implementing phase-cycling [130,131], it is also possible to distinguish different types of coupling and yields further helpful information about the chemical structure of a molecule [132]. |
T163 | 1471-1564 | Sentence | denotes | As an example, the use of the COSY experiment was presented in the work of Zheng et al. [88]. |
T164 | 1565-1776 | Sentence | denotes | The main goal of their work was to investigate potential biological differences and compare the pharmacological effects between Danggui (an herbal drug used in traditional Chinese medicine) and European Danggui. |
T165 | 1777-1911 | Sentence | denotes | For that, Zheng et al. treated blood deficiency rats with Danggui and European Danggui and collected samples of their serum and urine. |
T166 | 1912-2071 | Sentence | denotes | The samples were later measured using 1H-CPMG-NMR, 1H-NOESYPRESAT-1D, 1H,1H-COSY, and 1H,13C-HSQC, and then compared to equivalent spectra from untreated rats. |
T167 | 2072-2308 | Sentence | denotes | The results showed that exposure to Danggui and European Danggui altered the levels of 18 different metabolites, such as lactate, nicotinamide, glycerol and formate, which were involved in a total of seven different metabolism pathways. |
T168 | 2309-2482 | Sentence | denotes | Additionally, it was proven that Danggui and European Danggui have different chemical compositions, with Danggui having better blood-enriching effects than European Danggui. |