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PMC:7594251 / 18846-20827 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T48591 440-452 Body_part denotes phospholipid http://purl.org/sig/ont/fma/fma82779
T16532 515-518 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T27437 672-675 Body_part denotes DNA http://purl.org/sig/ont/fma/fma74412
T23683 1760-1765 Body_part denotes cells http://purl.org/sig/ont/fma/fma68646
T17125 1802-1806 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T92599 23-24 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T87879 55-56 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T52531 350-351 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T49797 697-705 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T79755 707-709 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T36380 808-809 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78941 858-860 http://purl.obolibrary.org/obo/PR_000005794 denotes CP
T26738 962-963 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T50950 1010-1018 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T83068 1061-1069 http://purl.obolibrary.org/obo/NCBITaxon_2 denotes bacteria
T72911 1115-1121 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T66455 1161-1162 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T71611 1280-1282 http://purl.obolibrary.org/obo/CLO_0001527 denotes 94
T15967 1382-1390 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeling
T47909 1676-1679 http://purl.obolibrary.org/obo/CLO_0001053 denotes 121
T76054 1760-1765 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T47371 1802-1806 http://purl.obolibrary.org/obo/GO_0005623 denotes cell

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T153 108-110 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T154 131-141 Chemical denotes phosphorus http://purl.obolibrary.org/obo/CHEBI_28659|http://purl.obolibrary.org/obo/CHEBI_35895
T156 198-202 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T157 243-254 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T158 306-315 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T159 352-367 Chemical denotes phosphorus atom http://purl.obolibrary.org/obo/CHEBI_28659|http://purl.obolibrary.org/obo/CHEBI_30207
T161 352-362 Chemical denotes phosphorus http://purl.obolibrary.org/obo/CHEBI_35895
T162 363-367 Chemical denotes atom http://purl.obolibrary.org/obo/CHEBI_33250
T163 440-452 Chemical denotes phospholipid http://purl.obolibrary.org/obo/CHEBI_16247
T164 465-468 Chemical denotes ATP http://purl.obolibrary.org/obo/CHEBI_15422|http://purl.obolibrary.org/obo/CHEBI_30616
T166 470-474 Chemical denotes NADP http://purl.obolibrary.org/obo/CHEBI_18009|http://purl.obolibrary.org/obo/CHEBI_25523
T168 515-518 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T169 672-675 Chemical denotes DNA http://purl.obolibrary.org/obo/CHEBI_16991
T170 824-826 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T171 858-860 Chemical denotes CP http://purl.obolibrary.org/obo/CHEBI_3380|http://purl.obolibrary.org/obo/CHEBI_73461
T173 921-931 Chemical denotes ampicillin http://purl.obolibrary.org/obo/CHEBI_28971
T174 1249-1259 Chemical denotes phosphorus http://purl.obolibrary.org/obo/CHEBI_28659|http://purl.obolibrary.org/obo/CHEBI_35895
T176 1265-1278 Chemical denotes nucleic acids http://purl.obolibrary.org/obo/CHEBI_33696
T177 1273-1278 Chemical denotes acids http://purl.obolibrary.org/obo/CHEBI_37527
T178 1492-1498 Chemical denotes chloro http://purl.obolibrary.org/obo/CHEBI_47853
T179 1567-1573 Chemical denotes lipids http://purl.obolibrary.org/obo/CHEBI_18059
T180 1585-1593 Chemical denotes hydroxyl http://purl.obolibrary.org/obo/CHEBI_29191|http://purl.obolibrary.org/obo/CHEBI_43176
T182 1595-1603 Chemical denotes aldehyde http://purl.obolibrary.org/obo/CHEBI_17478
T183 1975-1980 Chemical denotes drugs http://purl.obolibrary.org/obo/CHEBI_23888

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
219 7-13 Chemical denotes 1D 31P
232 775-782 Species denotes E. coli Tax:562
233 900-907 Species denotes E. coli Tax:562
234 108-110 Chemical denotes 1H
235 131-141 Chemical denotes phosphorus MESH:D010758
236 258-261 Chemical denotes 31P
237 352-362 Chemical denotes phosphorus MESH:D010758
238 379-382 Chemical denotes 31P
239 440-452 Chemical denotes phospholipid MESH:D010743
240 465-468 Chemical denotes ATP MESH:D000255
241 470-474 Chemical denotes NADP MESH:D009249
242 921-931 Chemical denotes ampicillin MESH:D000667
243 1249-1259 Chemical denotes phosphorus MESH:D010758
251 1370-1373 Chemical denotes 13C MESH:C000615229
252 1378-1381 Chemical denotes 15N
253 1490-1534 Chemical denotes 2-chloro-4,4,5,5-tetramethyldioxaphospholane MESH:C548759
254 1536-1541 Chemical denotes CTMDP MESH:C548759
255 1567-1573 Chemical denotes lipids MESH:D008055
256 1595-1603 Chemical denotes aldehyde MESH:D000447
257 1609-1617 Chemical denotes carboxyl

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T20318 440-463 http://purl.obolibrary.org/obo/GO_0006644 denotes phospholipid metabolism
T95169 453-463 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T97670 1890-1900 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T133 0-6 Sentence denotes 2.1.4.
T134 7-17 Sentence denotes 1D 31P-NMR
T135 18-229 Sentence denotes With a natural abundance of 100% and a gyromagnetic ratio of about 2.5 times smaller than 1H, one may think that phosphorus could be broadly used for NMR experiments regarding the drug discovery and development.
T136 230-368 Sentence denotes However, the application of 31P is limited due to the fact that most of the molecules of interest simply do not contain a phosphorus atom.
T137 369-532 Sentence denotes Therefore 31P-NMR is usually applicable for studies related to energy, phospholipid metabolism (ATP, NADP), and/or characterization of changes in DNA [94,119,120].
T138 533-711 Sentence denotes For example, Overall et al. conducted an experiment in which they showed that 31P solid-state NMR can be used for quantitative analysis of DNA dynamics within live bacteria [94].
T139 712-873 Sentence denotes For that, the researchers first prepared untreated cultures of E. coli, and measured them using a Hartmann-Hahn 1H to 31P cross-polarization (31P CP) experiment.
T140 874-979 Sentence denotes Afterwards, they measured E. coli treated with ampicillin and maculatin 1.1 (Mac1.1) in a similar manner.
T141 980-1284 Sentence denotes Spectra obtained from treated bacteria compared to those obtained from untreated bacteria showed alterations in the lineshape, reduced signal intensity at the spectrum’s edges, and a shift in spectral density towards 0 ppm which indicated the increased dynamics of the phosphorus from nucleic acids [94].
T142 1285-1361 Sentence denotes Over time, several innovations have been applied to expand the usage of 31P.
T143 1362-1463 Sentence denotes Like in 13C and 15N labeling of specific biological compounds, incorporation of 31P can also be used.
T144 1464-1681 Sentence denotes In order to achieve that, 2-chloro-4,4,5,5-tetramethyldioxaphospholane (CTMDP) can be used for tagging lipids containing hydroxyl, aldehyde, and carboxyl groups that can later be detected with better resolution [121].
T145 1682-1823 Sentence denotes Another fairly recent method enables toxicological screening of 31P in living cells for several hours without affecting cell viability [122].
T146 1824-1981 Sentence denotes This specific method can be used to observe the changes in energy metabolism in real-time while enabling the evaluation of the effects of administered drugs.