PMC:7594251 / 17397-18519
Annnotations
LitCovid-PD-CLO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T45804 | 43-46 | http://purl.obolibrary.org/obo/CLO_0051582 | denotes | has |
| T42617 | 47-48 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T69056 | 225-226 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T13009 | 358-359 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T53392 | 491-492 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T47108 | 538-539 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T33086 | 612-619 | http://purl.obolibrary.org/obo/CLO_0009985 | denotes | focuses |
| T45570 | 709-715 | http://purl.obolibrary.org/obo/SO_0000418 | denotes | signal |
| T41073 | 722-723 | http://purl.obolibrary.org/obo/CLO_0001020 | denotes | a |
| T98684 | 826-834 | http://purl.obolibrary.org/obo/CLO_0007225 | denotes | labeling |
| T86896 | 857-860 | http://purl.obolibrary.org/obo/CLO_0053001 | denotes | 114 |
LitCovid-PD-CHEBI
| Id | Subject | Object | Predicate | Lexical cue | chebi_id |
|---|---|---|---|---|---|
| T145 | 116-118 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T146 | 269-271 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T147 | 351-353 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T148 | 409-411 | Chemical | denotes | 1H | http://purl.obolibrary.org/obo/CHEBI_49637 |
| T149 | 631-640 | Chemical | denotes | molecules | http://purl.obolibrary.org/obo/CHEBI_25367 |
| T150 | 672-684 | Chemical | denotes | ethanolamine | http://purl.obolibrary.org/obo/CHEBI_16000|http://purl.obolibrary.org/obo/CHEBI_23981|http://purl.obolibrary.org/obo/CHEBI_57603 |
LitCovid-PubTator
| Id | Subject | Object | Predicate | Lexical cue | tao:has_database_id |
|---|---|---|---|---|---|
| 206 | 722-726 | Gene | denotes | a 2D | Gene:11273 |
| 207 | 39-42 | Chemical | denotes | 15N | |
| 208 | 87-90 | Chemical | denotes | 13C | MESH:C000615229 |
| 209 | 116-118 | Chemical | denotes | 1H | |
| 210 | 269-271 | Chemical | denotes | 1H | |
| 211 | 289-292 | Chemical | denotes | 15N | |
| 212 | 351-353 | Chemical | denotes | 1H | |
| 213 | 391-394 | Chemical | denotes | 15N | |
| 214 | 409-411 | Chemical | denotes | 1H | |
| 215 | 509-512 | Chemical | denotes | 15N | |
| 216 | 533-536 | Chemical | denotes | 13C | MESH:C000615229 |
| 217 | 668-684 | Chemical | denotes | 15N-ethanolamine |
LitCovid-sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T123 | 0-119 | Sentence | denotes | In comparison to the previous example, 15N has a lower shift dispersion (~100ppm) than 13C, but higher than that of 1H. |
| T124 | 120-272 | Sentence | denotes | Here, the situation is unfortunately severely limited due to an even lower natural abundance (0.37%) and a gyromagnetic ratio ~10 times smaller than 1H. |
| T125 | 273-354 | Sentence | denotes | This means that 15N’s combined sensitivity is around 260,000 times lower than 1H. |
| T126 | 355-521 | Sentence | denotes | As a result, isotopic enrichment of 15N combined with 1H-mediated enhancement via indirect detection is often needed in order to obtain a satisfactory 1D 15N spectra. |
| T127 | 522-599 | Sentence | denotes | Similar to 13C, a few methods are available to overcome such low sensitivity. |
| T128 | 600-774 | Sentence | denotes | One of them focuses on tagging molecules with carboxyl groups using 15N-ethanolamine and later detecting the signal using a 2D heteronuclear correlation NMR experiment [113]. |
| T129 | 775-862 | Sentence | denotes | Currently, novel approaches such as “smart isotope labeling” have been developed [114]. |
| T130 | 863-1122 | Sentence | denotes | Also, the SOFAST (Band-Selective Optimized Flip Angle Short Transient) technique can help but results in substantial hardware considerations/drawbacks and often increased concentrations, and/or dramatically longer experiments are still required [115,116,117]. |