PMC:7594251 / 129329-132613 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T136 1294-1296 Body_part denotes CS http://purl.org/sig/ont/fma/fma284995
T137 2001-2008 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T138 2239-2243 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T139 2301-2311 Body_part denotes cell parts http://purl.org/sig/ont/fma/fma78563
T140 2301-2305 Body_part denotes cell http://purl.org/sig/ont/fma/fma68646
T141 2432-2439 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T142 2508-2515 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T143 2593-2601 Body_part denotes proteins http://purl.org/sig/ont/fma/fma67257
T144 2864-2871 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257

LitCovid-PD-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T49 2301-2311 Body_part denotes cell parts http://purl.obolibrary.org/obo/UBERON_0000470

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T144 1077-1080 Disease denotes MDD http://purl.obolibrary.org/obo/MONDO_0012048|http://purl.obolibrary.org/obo/MONDO_0016217
T146 2010-2013 Disease denotes STD http://purl.obolibrary.org/obo/MONDO_0021681
T147 2809-2812 Disease denotes HTS http://purl.obolibrary.org/obo/MONDO_0011549

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T261 450-458 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeling
T262 697-698 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T263 1594-1595 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T264 2029-2030 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T265 2239-2243 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T266 2283-2288 http://purl.obolibrary.org/obo/CLO_0009985 denotes focus
T267 2301-2305 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T268 2322-2330 http://purl.obolibrary.org/obo/CLO_0007225 denotes labeling
T269 2847-2852 http://purl.obolibrary.org/obo/NCBITaxon_9606 denotes human
T270 2912-2913 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T271 2935-2936 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T272 2962-2963 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T273 3025-3026 http://purl.obolibrary.org/obo/CLO_0001020 denotes a

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T49784 370-376 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T78546 388-390 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T55022 521-530 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T52980 578-584 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T56383 1077-1080 Chemical denotes MDD http://purl.obolibrary.org/obo/CHEBI_566274
T21913 1294-1296 Chemical denotes CS http://purl.obolibrary.org/obo/CHEBI_73462
T84653 1670-1677 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T60113 1850-1856 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T79064 1991-1997 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T3417 2001-2008 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T86859 2104-2110 Chemical denotes ligand http://purl.obolibrary.org/obo/CHEBI_52214
T53221 2136-2143 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214
T59728 2432-2439 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89255 2440-2444 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T90308 2493-2497 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T26569 2508-2515 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T60248 2593-2601 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T69582 2625-2629 Chemical denotes ions http://purl.obolibrary.org/obo/CHEBI_24870
T8333 2712-2717 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T65120 2853-2855 Chemical denotes La http://purl.obolibrary.org/obo/CHEBI_33336
T78430 2856-2863 Chemical denotes antigen http://purl.obolibrary.org/obo/CHEBI_59132
T1428 2864-2871 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T14147 2914-2931 Chemical denotes chemical compound http://purl.obolibrary.org/obo/CHEBI_37577
T89705 3206-3213 Chemical denotes ligands http://purl.obolibrary.org/obo/CHEBI_52214

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
2421 1294-1296 Gene denotes CS Gene:1431
2422 3107-3111 Gene denotes spin Gene:10927
2423 630-634 Gene denotes spin Gene:10927
2424 2971-2975 Gene denotes pill Gene:8319132
2425 186-190 Gene denotes High Gene:104137
2426 1805-1808 Species denotes SAR Tax:2698737
2427 2847-2852 Species denotes human Tax:9606
2428 282-284 Chemical denotes 2D
2429 303-305 Chemical denotes 2D
2430 388-390 Chemical denotes 1H
2431 1635-1639 Chemical denotes FBDD
2432 2619-2624 Chemical denotes metal MESH:D008670
2433 1077-1080 Disease denotes MDD MESH:D003865

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T61 2185-2193 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange
T62 2834-2843 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T906 0-90 Sentence denotes Table 3 Advantages and limitations of different NMR techniques developed in recent years.
T907 91-131 Sentence denotes NMR Technique Advantages Disadvantages
T908 132-289 Sentence denotes 1D-NMR Ability to identify simple chemical compounds.High quality resolution and sensitivity for many 1D experiments.Less time consuming compared to 2D NMR.
T909 291-484 Sentence denotes Compared to 2D NMR less details can be obtained for more complex molecules.For nuclei other than 1H and 19F, relative sensitivity is fairly low—requires extra labeling to obtain better spectra.
T910 485-665 Sentence denotes 2D NMR Ability to identify complex molecules and observe different interactions between the nuclei, e.g., correlations between all spins in one spin system using TOCSY experiment.
T911 667-727 Sentence denotes Requires long times to obtain a proper spectra (up to days).
T912 728-788 Sentence denotes Ultrafast 2D NMR Greatly reduces time to obtain 2D spectra.
T913 790-810 Sentence denotes Reduced sensitivity.
T914 811-866 Sentence denotes SOFAST Significantly reduces acquisition time of HMQC.
T915 868-893 Sentence denotes Relatively low resolution
T916 894-973 Sentence denotes NUS Lowers the time of measurement while keeping the same level of resolution.
T917 975-1076 Sentence denotes Requires use of reconstruction algorithms since missing data points can lead to artifacts in spectra.
T918 1077-1207 Sentence denotes MDD Multidimensional data are “broken” to one dimensional, which are easier to analyze.Ability to resolve overlapping resonances.
T919 1210-1293 Sentence denotes Data must be (approximately) symmetrical (Lorentzian shape) to obtain good spectra.
T920 1294-1334 Sentence denotes CS Good reconstruction of weaker peaks.
T921 1336-1393 Sentence denotes Large computational costs, low performance on noisy data.
T922 1394-1445 Sentence denotes MAX ENT Significant reduction in acquisition time.
T923 1447-1534 Sentence denotes Nominally Lorentzian peak shapes may be distorted, and peak intensities may be altered.
T924 1535-1583 Sentence denotes IST Greatly reduced time to obtain NMR spectra.
T925 1585-1634 Sentence denotes Requires a grid of uniformly sampled data points.
T926 1635-1741 Sentence denotes FBDD Often makes stronger binding ligands from weakly binding fragments.Less time and resource intensive.
T927 1743-1804 Sentence denotes Can be used only for small fragments of compound of interest.
T928 1805-1857 Sentence denotes SAR Direct observation of target binding to ligand.
T929 1858-1904 Sentence denotes Several types of NMR experiments are possible.
T930 1906-2009 Sentence denotes Inability to distinguish binding modes, difficult to gage the “true” binding site of ligand to protein.
T931 2010-2119 Sentence denotes STD Only requires a small amount of sample.Highly reproducible.Allows direct observations of ligand binding.
T932 2121-2195 Sentence denotes Only works for ligands with low binding affinity (fast chemical exchange).
T933 2196-2235 Sentence denotes Inability to distinguish binding modes.
T934 2236-2312 Sentence denotes In cell NMR In vivo studies are possible, can focus on specific cell parts.
T935 2314-2358 Sentence denotes Special labeling techniques may be required.
T936 2359-2404 Sentence denotes Spectra may be more challenging to interpret.
T937 2405-2574 Sentence denotes In silico + NMR Can model protein drug interactions, helps speed up and reduce cost of drug delivery Protein models need to be validated through experimental approach.
T938 2575-2718 Sentence denotes PNMR Can observe proteins interacting with metal ions, long observation distance (10-25 angstroms) between paramagnetic left and nearby atoms.
T939 2720-2761 Sentence denotes Paramagnetic left required in the system.
T940 2762-2872 Sentence denotes ALARM NMR Elimination of false positives from HTS methods It requires synthesis of human La antigen protein.
T941 2873-3036 Sentence denotes ssNMR Enables the characterization of a chemical compound in a solid-state form such as a tablet/pill.Provides insight into the physical properties of a compound.
T942 3038-3125 Sentence denotes Significant broadening of the spectral lineshapes due to anisotropic spin interactions.
T943 3126-3214 Sentence denotes Relaxation editing Noticeable difference in spectra of binding and non-binding ligands.
T944 3216-3284 Sentence denotes Sets the lower limit of time for which experiments can be performed.