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PMC:7594251 / 12679-15760 JSONTXT

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LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T7693 40-43 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T74928 110-116 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T89386 146-147 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25318 171-181 http://purl.obolibrary.org/obo/UBERON_0003103 denotes in organic
T33905 722-723 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T68532 742-747 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T34126 951-954 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T31583 955-956 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16829 990-997 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T20933 1030-1036 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T99257 1216-1222 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T77549 1407-1413 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T61613 1442-1443 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96943 1634-1635 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55349 1721-1722 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77383 1737-1742 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T73188 1782-1783 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78366 1835-1840 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T25547 2096-2097 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31964 2165-2166 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20822 2275-2276 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63367 2464-2470 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T91886 2575-2576 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73157 2717-2720 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7374 2870-2877 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T55495 2885-2886 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28108 2981-2984 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T84 4-6 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T85 7-15 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T86 87-94 Chemical denotes tritium http://purl.obolibrary.org/obo/CHEBI_29238
T87 117-123 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T88 220-222 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T89 354-356 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T90 446-455 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T91 488-492 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T92 507-511 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T93 570-575 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T94 592-599 Chemical denotes solvent http://purl.obolibrary.org/obo/CHEBI_46787
T95 777-782 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T96 835-840 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T97 1022-1029 Chemical denotes solvent http://purl.obolibrary.org/obo/CHEBI_46787
T98 1210-1215 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T99 1240-1248 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T100 1254-1257 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377
T101 1261-1269 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T102 1288-1293 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T103 1313-1321 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T104 1390-1395 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T105 1401-1406 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T106 1525-1533 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T107 1562-1567 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T108 1932-1937 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T109 1959-1964 Chemical denotes WATER http://purl.obolibrary.org/obo/CHEBI_15377
T110 2148-2153 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T111 2257-2262 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T112 2365-2376 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T113 2432-2437 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T114 2577-2582 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T115 2806-2808 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T116 2831-2838 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T117 2935-2937 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T118 3021-3027 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
115 1360-1364 Gene denotes spin Gene:10927
116 4-6 Chemical denotes 1H
117 7-15 Chemical denotes hydrogen MESH:D006859
118 87-94 Chemical denotes tritium MESH:D014316
119 217-219 Chemical denotes 1D
120 220-222 Chemical denotes 1H
121 354-356 Chemical denotes 1H
122 570-575 Chemical denotes water MESH:D014867
123 777-782 Chemical denotes water MESH:D014867
124 835-840 Chemical denotes water MESH:D014867
125 1210-1215 Chemical denotes water MESH:D014867
126 1240-1248 Chemical denotes hydrogen MESH:D006859
127 1254-1257 Chemical denotes H2O
128 1401-1406 Chemical denotes water MESH:D014867
129 1562-1567 Chemical denotes water MESH:D014867
130 1932-1937 Chemical denotes water MESH:D014867
131 1959-1964 Chemical denotes WATER MESH:D014867
132 2148-2153 Chemical denotes water MESH:D014867
133 2257-2262 Chemical denotes water MESH:D014867
134 2432-2437 Chemical denotes water MESH:D014867
135 2577-2582 Chemical denotes water MESH:D014867
136 2806-2808 Chemical denotes 1H
137 2935-2937 Chemical denotes 1H
138 3036-3039 Chemical denotes 13C MESH:C000615229
139 3041-3044 Chemical denotes 15N

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T6950 1274-1282 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T90 0-201 Sentence denotes The 1H hydrogen isotope is NMR visible, has the highest gyromagnetic ratio (apart from tritium) of all of NMR active nuclei, and is combined with a vast natural abundance in organic chemical compounds.
T91 202-277 Sentence denotes This makes the 1D-1H-NMR experiment the most commonly applied NMR approach.
T92 278-470 Sentence denotes Moreover, many software databases [99,100,101,102] are well established for 1H-NMR spectra therefore assisting with processing, analyzing, and identifying the detected molecules automatically.
T93 471-638 Sentence denotes Since almost all drug discovery and drug development studies are performed on samples dissolved in water, many different solvent suppression methods have been applied.
T94 639-682 Sentence denotes The most common is presaturation [103,104].
T95 683-783 Sentence denotes The key point of this method is to use a low power induced field at the specific frequency of water.
T96 784-851 Sentence denotes This effectively averages out any coherence of the water resonance.
T97 852-1101 Sentence denotes The experiment is simple for common hardware to perform and easy to set up; however, presaturation has a substantial disadvantage in that signals resonating close to the solvent signal will show decreased intensity [103,104] or may be lost entirely.
T98 1102-1223 Sentence denotes This is due to the fact the even selective pulses or very low power pulses also excite some area around the water signal.
T99 1224-1396 Sentence denotes Also suppressed hydrogen from H2O in solution can exchange with atoms of interest in the molecule and effectively bleed the suppressive spin state to any neighboring atoms.
T100 1397-1549 Sentence denotes The water signal itself is usually broad, so a wider area of suppression is not necessarily undesirable but affects more of the molecule(s) of interest.
T101 1550-1683 Sentence denotes More recent water suppression techniques have been developed such as those based on a scheme known as excitation sculpting [105,106].
T102 1684-1857 Sentence denotes The basic pulse sequence consists of a double pulsed field gradient echo (DPFGE) in each of which a selective component pulse is flanked by two pulsed field gradients [107].
T103 1858-1916 Sentence denotes The particular elements differ for different applications.
T104 1917-2229 Sentence denotes In the case of water suppression known as WATER suppression by GrAdient Tailored Excitation (WATERGATE), this involves an initial encoding gradient along with the middle element; a combination of two selective 90° rotations on the water along with a central non-selective 180° excitation of all resonances [108].
T105 2230-2360 Sentence denotes This is predicated in that water experiences a 360° rotation (effectively nothing) while all other spins experience 180° rotation.
T106 2361-2471 Sentence denotes The application of the second refocusing gradient does not rephase the water and therefore removes the signal.
T107 2472-2560 Sentence denotes The reader is referred to the detailed literature [103,104,109] for further information.
T108 2561-2796 Sentence denotes In principle, a water suppression element (or many elements combined) can be incorporated in any existing pulse sequence to enhance the performance, and it has been implemented in various 1D, 2D, and triple resonance 3D/4D experiments.
T109 2797-2975 Sentence denotes Although 1H is the most sensitive nucleus for NMR yielding strong, sharp signals within a few minutes [110], chemical shift dispersion of 1H is quite narrow (only around 10 ppm).
T110 2976-3081 Sentence denotes This has prompted the consideration of other nuclei such as 13C, 15N, or 31P for resolution improvements.