> top > docs > PMC:7594251 > spans > 12662-15760 > annotations

PMC:7594251 / 12662-15760 JSONTXT

Annnotations TAB JSON ListView MergeView

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T7693 57-60 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T74928 127-133 http://purl.obolibrary.org/obo/CLO_0001658 denotes active
T89386 163-164 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25318 188-198 http://purl.obolibrary.org/obo/UBERON_0003103 denotes in organic
T33905 739-740 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T68532 759-764 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T34126 968-971 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T31583 972-973 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T16829 1007-1014 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T20933 1047-1053 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T99257 1233-1239 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T77549 1424-1430 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T61613 1459-1460 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T96943 1651-1652 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T55349 1738-1739 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T77383 1754-1759 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T73188 1799-1800 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T78366 1852-1857 http://purl.obolibrary.org/obo/UBERON_0007688 denotes field
T25547 2113-2114 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T31964 2182-2183 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T20822 2292-2293 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T63367 2481-2487 http://purl.obolibrary.org/obo/SO_0000418 denotes signal
T91886 2592-2593 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T73157 2734-2737 http://purl.obolibrary.org/obo/CLO_0051582 denotes has
T7374 2887-2894 http://purl.obolibrary.org/obo/SO_0000418 denotes signals
T55495 2902-2903 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T28108 2998-3001 http://purl.obolibrary.org/obo/CLO_0051582 denotes has

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T83 10-12 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T84 21-23 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T85 24-32 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T86 104-111 Chemical denotes tritium http://purl.obolibrary.org/obo/CHEBI_29238
T87 134-140 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252
T88 237-239 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T89 371-373 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T90 463-472 Chemical denotes molecules http://purl.obolibrary.org/obo/CHEBI_25367
T91 505-509 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T92 524-528 Chemical denotes drug http://purl.obolibrary.org/obo/CHEBI_23888
T93 587-592 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T94 609-616 Chemical denotes solvent http://purl.obolibrary.org/obo/CHEBI_46787
T95 794-799 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T96 852-857 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T97 1039-1046 Chemical denotes solvent http://purl.obolibrary.org/obo/CHEBI_46787
T98 1227-1232 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T99 1257-1265 Chemical denotes hydrogen http://purl.obolibrary.org/obo/CHEBI_49637
T100 1271-1274 Chemical denotes H2O http://purl.obolibrary.org/obo/CHEBI_15377
T101 1278-1286 Chemical denotes solution http://purl.obolibrary.org/obo/CHEBI_75958
T102 1305-1310 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T103 1330-1338 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T104 1407-1412 Chemical denotes atoms http://purl.obolibrary.org/obo/CHEBI_33250
T105 1418-1423 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T106 1542-1550 Chemical denotes molecule http://purl.obolibrary.org/obo/CHEBI_25367
T107 1579-1584 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T108 1949-1954 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T109 1976-1981 Chemical denotes WATER http://purl.obolibrary.org/obo/CHEBI_15377
T110 2165-2170 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T111 2274-2279 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T112 2382-2393 Chemical denotes application http://purl.obolibrary.org/obo/CHEBI_33232
T113 2449-2454 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T114 2594-2599 Chemical denotes water http://purl.obolibrary.org/obo/CHEBI_15377
T115 2823-2825 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T116 2848-2855 Chemical denotes nucleus http://purl.obolibrary.org/obo/CHEBI_33252
T117 2952-2954 Chemical denotes 1H http://purl.obolibrary.org/obo/CHEBI_49637
T118 3038-3044 Chemical denotes nuclei http://purl.obolibrary.org/obo/CHEBI_33252

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
89 7-12 Chemical denotes 1D 1H
115 1377-1381 Gene denotes spin Gene:10927
116 21-23 Chemical denotes 1H
117 24-32 Chemical denotes hydrogen MESH:D006859
118 104-111 Chemical denotes tritium MESH:D014316
119 234-236 Chemical denotes 1D
120 237-239 Chemical denotes 1H
121 371-373 Chemical denotes 1H
122 587-592 Chemical denotes water MESH:D014867
123 794-799 Chemical denotes water MESH:D014867
124 852-857 Chemical denotes water MESH:D014867
125 1227-1232 Chemical denotes water MESH:D014867
126 1257-1265 Chemical denotes hydrogen MESH:D006859
127 1271-1274 Chemical denotes H2O
128 1418-1423 Chemical denotes water MESH:D014867
129 1579-1584 Chemical denotes water MESH:D014867
130 1949-1954 Chemical denotes water MESH:D014867
131 1976-1981 Chemical denotes WATER MESH:D014867
132 2165-2170 Chemical denotes water MESH:D014867
133 2274-2279 Chemical denotes water MESH:D014867
134 2449-2454 Chemical denotes water MESH:D014867
135 2594-2599 Chemical denotes water MESH:D014867
136 2823-2825 Chemical denotes 1H
137 2952-2954 Chemical denotes 1H
138 3053-3056 Chemical denotes 13C MESH:C000615229
139 3058-3061 Chemical denotes 15N

LitCovid-PD-GO-BP

Id Subject Object Predicate Lexical cue
T6950 1291-1299 http://purl.obolibrary.org/obo/GO_0015297 denotes exchange

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T88 0-6 Sentence denotes 2.1.1.
T89 7-16 Sentence denotes 1D 1H-NMR
T90 17-218 Sentence denotes The 1H hydrogen isotope is NMR visible, has the highest gyromagnetic ratio (apart from tritium) of all of NMR active nuclei, and is combined with a vast natural abundance in organic chemical compounds.
T91 219-294 Sentence denotes This makes the 1D-1H-NMR experiment the most commonly applied NMR approach.
T92 295-487 Sentence denotes Moreover, many software databases [99,100,101,102] are well established for 1H-NMR spectra therefore assisting with processing, analyzing, and identifying the detected molecules automatically.
T93 488-655 Sentence denotes Since almost all drug discovery and drug development studies are performed on samples dissolved in water, many different solvent suppression methods have been applied.
T94 656-699 Sentence denotes The most common is presaturation [103,104].
T95 700-800 Sentence denotes The key point of this method is to use a low power induced field at the specific frequency of water.
T96 801-868 Sentence denotes This effectively averages out any coherence of the water resonance.
T97 869-1118 Sentence denotes The experiment is simple for common hardware to perform and easy to set up; however, presaturation has a substantial disadvantage in that signals resonating close to the solvent signal will show decreased intensity [103,104] or may be lost entirely.
T98 1119-1240 Sentence denotes This is due to the fact the even selective pulses or very low power pulses also excite some area around the water signal.
T99 1241-1413 Sentence denotes Also suppressed hydrogen from H2O in solution can exchange with atoms of interest in the molecule and effectively bleed the suppressive spin state to any neighboring atoms.
T100 1414-1566 Sentence denotes The water signal itself is usually broad, so a wider area of suppression is not necessarily undesirable but affects more of the molecule(s) of interest.
T101 1567-1700 Sentence denotes More recent water suppression techniques have been developed such as those based on a scheme known as excitation sculpting [105,106].
T102 1701-1874 Sentence denotes The basic pulse sequence consists of a double pulsed field gradient echo (DPFGE) in each of which a selective component pulse is flanked by two pulsed field gradients [107].
T103 1875-1933 Sentence denotes The particular elements differ for different applications.
T104 1934-2246 Sentence denotes In the case of water suppression known as WATER suppression by GrAdient Tailored Excitation (WATERGATE), this involves an initial encoding gradient along with the middle element; a combination of two selective 90° rotations on the water along with a central non-selective 180° excitation of all resonances [108].
T105 2247-2377 Sentence denotes This is predicated in that water experiences a 360° rotation (effectively nothing) while all other spins experience 180° rotation.
T106 2378-2488 Sentence denotes The application of the second refocusing gradient does not rephase the water and therefore removes the signal.
T107 2489-2577 Sentence denotes The reader is referred to the detailed literature [103,104,109] for further information.
T108 2578-2813 Sentence denotes In principle, a water suppression element (or many elements combined) can be incorporated in any existing pulse sequence to enhance the performance, and it has been implemented in various 1D, 2D, and triple resonance 3D/4D experiments.
T109 2814-2992 Sentence denotes Although 1H is the most sensitive nucleus for NMR yielding strong, sharp signals within a few minutes [110], chemical shift dispersion of 1H is quite narrow (only around 10 ppm).
T110 2993-3098 Sentence denotes This has prompted the consideration of other nuclei such as 13C, 15N, or 31P for resolution improvements.