PMC:7594251 / 122343-122659 JSONTXT

{"project":"LitCovid-PD-FMA-UBERON","denotations":[{"id":"T97","span":{"begin":29,"end":33},"obj":"Body_part"},{"id":"T98","span":{"begin":132,"end":146},"obj":"Body_part"},{"id":"T99","span":{"begin":132,"end":136},"obj":"Body_part"}],"attributes":[{"id":"A97","pred":"fma_id","subj":"T97","obj":"http://purl.org/sig/ont/fma/fma68646"},{"id":"A98","pred":"fma_id","subj":"T98","obj":"http://purl.org/sig/ont/fma/fma63841"},{"id":"A99","pred":"fma_id","subj":"T99","obj":"http://purl.org/sig/ont/fma/fma68646"}],"text":"Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h). Additionally, Ptac2S may inhibit lactate dehydrogenase. 1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]"}

{"project":"LitCovid-PD-MONDO","denotations":[{"id":"T127","span":{"begin":22,"end":28},"obj":"Disease"}],"attributes":[{"id":"A127","pred":"mondo_id","subj":"T127","obj":"http://purl.obolibrary.org/obo/MONDO_0004992"}],"text":"Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h). Additionally, Ptac2S may inhibit lactate dehydrogenase. 1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]"}

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T191","span":{"begin":29,"end":33},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T192","span":{"begin":35,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0009063"},{"id":"T193","span":{"begin":35,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0052004"},{"id":"T194","span":{"begin":35,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0052005"},{"id":"T195","span":{"begin":35,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0052006"},{"id":"T196","span":{"begin":35,"end":41},"obj":"http://purl.obolibrary.org/obo/CLO_0052007"},{"id":"T197","span":{"begin":132,"end":136},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T198","span":{"begin":137,"end":146},"obj":"http://purl.obolibrary.org/obo/UBERON_0000158"},{"id":"T199","span":{"begin":150,"end":151},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"}],"text":"Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h). Additionally, Ptac2S may inhibit lactate dehydrogenase. 1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]"}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T7971","span":{"begin":91,"end":102},"obj":"Chemical"},{"id":"T48239","span":{"begin":98,"end":102},"obj":"Chemical"},{"id":"T66521","span":{"begin":192,"end":201},"obj":"Chemical"},{"id":"T82218","span":{"begin":242,"end":249},"obj":"Chemical"},{"id":"T68362","span":{"begin":266,"end":268},"obj":"Chemical"},{"id":"T57321","span":{"begin":280,"end":282},"obj":"Chemical"}],"attributes":[{"id":"A23639","pred":"chebi_id","subj":"T7971","obj":"http://purl.obolibrary.org/obo/CHEBI_30769"},{"id":"A43710","pred":"chebi_id","subj":"T48239","obj":"http://purl.obolibrary.org/obo/CHEBI_37527"},{"id":"A28292","pred":"chebi_id","subj":"T66521","obj":"http://purl.obolibrary.org/obo/CHEBI_27899"},{"id":"A60125","pred":"chebi_id","subj":"T82218","obj":"http://purl.obolibrary.org/obo/CHEBI_24996"},{"id":"A85645","pred":"chebi_id","subj":"T68362","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A72739","pred":"chebi_id","subj":"T57321","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"}],"text":"Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h). Additionally, Ptac2S may inhibit lactate dehydrogenase. 1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]"}

{"project":"LitCovid-PubTator","denotations":[{"id":"2234","span":{"begin":91,"end":102},"obj":"Chemical"},{"id":"2235","span":{"begin":192,"end":201},"obj":"Chemical"},{"id":"2236","span":{"begin":223,"end":229},"obj":"Chemical"},{"id":"2237","span":{"begin":266,"end":268},"obj":"Chemical"},{"id":"2238","span":{"begin":290,"end":293},"obj":"Chemical"},{"id":"2239","span":{"begin":301,"end":309},"obj":"Chemical"},{"id":"2353","span":{"begin":22,"end":28},"obj":"Disease"},{"id":"2375","span":{"begin":281,"end":289},"obj":"CellLine"}],"attributes":[{"id":"A2234","pred":"tao:has_database_id","subj":"2234","obj":"MESH:D019343"},{"id":"A2235","pred":"tao:has_database_id","subj":"2235","obj":"MESH:D002945"},{"id":"A2238","pred":"tao:has_database_id","subj":"2238","obj":"MESH:C000615229"},{"id":"A2353","pred":"tao:has_database_id","subj":"2353","obj":"MESH:D009369"},{"id":"A2375","pred":"tao:has_database_id","subj":"2375","obj":"CVCL:Z499"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h). Additionally, Ptac2S may inhibit lactate dehydrogenase. 1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]"}

{"project":"LitCovid-PD-GO-BP","denotations":[{"id":"T22","span":{"begin":91,"end":108},"obj":"http://purl.obolibrary.org/obo/GO_0006099"}],"text":"Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h). Additionally, Ptac2S may inhibit lactate dehydrogenase. 1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]"}

{"project":"LitCovid-PD-HP","denotations":[{"id":"T24","span":{"begin":22,"end":28},"obj":"Phenotype"}],"attributes":[{"id":"A24","pred":"hp_id","subj":"T24","obj":"http://purl.obolibrary.org/obo/HP_0002664"}],"text":"Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h). Additionally, Ptac2S may inhibit lactate dehydrogenase. 1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]"}

{"project":"LitCovid-sentences","denotations":[{"id":"T842","span":{"begin":0,"end":208},"obj":"Sentence"},{"id":"T843","span":{"begin":209,"end":264},"obj":"Sentence"},{"id":"T844","span":{"begin":266,"end":316},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Ptac2S Ptac2S limits cancer cell (Skov-3) proliferation by reducing the efficiency of the citric acid cycle and induces changes in cell membranes in a shorter period of time (6h) compared to cisplatin (24h). Additionally, Ptac2S may inhibit lactate dehydrogenase. 1H-NMR CPMG1H,1H-COSY1H,13C-HSQC1H,13C-HMBC [145]"}