PMC:7594251 / 109327-110244 JSONTXT

{"project":"LitCovid-PD-CLO","denotations":[{"id":"T114","span":{"begin":180,"end":185},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"},{"id":"T115","span":{"begin":209,"end":210},"obj":"http://purl.obolibrary.org/obo/CLO_0001020"},{"id":"T116","span":{"begin":246,"end":251},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"},{"id":"T117","span":{"begin":447,"end":452},"obj":"http://purl.obolibrary.org/obo/UBERON_0007688"},{"id":"T118","span":{"begin":473,"end":476},"obj":"http://purl.obolibrary.org/obo/CLO_0051582"},{"id":"T119","span":{"begin":593,"end":604},"obj":"http://purl.obolibrary.org/obo/OBI_0000968"},{"id":"T120","span":{"begin":749,"end":755},"obj":"http://purl.obolibrary.org/obo/SO_0000418"}],"text":"While always important in drug design, sensitivity and resolution of NMR are two major factors that need special consideration. Since both factors improve with increasing magnetic field strength, we have seen a spike in the demand for ultra-high-field NMR spectrometers. Recently, 28.2 T (i.e., 1.2 GHz for 1H) magnets have become commercially available, and with recent advances in magnet technology, such as liquid helium recycling and magnetic field shielding [91], NMR has begun to offer far better resolution and higher sensitivity while reducing the substantial costs of maintaining the instruments compared to past decades. Other steps have been taken to enhance the sensitivity of NMR including: the development of cryoprobes increasing the signal to noise ratio 3 to 4 times, and micro-coil probes that not only increased sensitivity but also reduced the amount of sample required for the measurements [445]."}

{"project":"LitCovid-PD-CHEBI","denotations":[{"id":"T31918","span":{"begin":26,"end":30},"obj":"Chemical"},{"id":"T99336","span":{"begin":307,"end":309},"obj":"Chemical"},{"id":"T52045","span":{"begin":417,"end":423},"obj":"Chemical"}],"attributes":[{"id":"A81379","pred":"chebi_id","subj":"T31918","obj":"http://purl.obolibrary.org/obo/CHEBI_23888"},{"id":"A26208","pred":"chebi_id","subj":"T99336","obj":"http://purl.obolibrary.org/obo/CHEBI_49637"},{"id":"A46185","pred":"chebi_id","subj":"T52045","obj":"http://purl.obolibrary.org/obo/CHEBI_30217"},{"id":"A50808","pred":"chebi_id","subj":"T52045","obj":"http://purl.obolibrary.org/obo/CHEBI_33681"}],"text":"While always important in drug design, sensitivity and resolution of NMR are two major factors that need special consideration. Since both factors improve with increasing magnetic field strength, we have seen a spike in the demand for ultra-high-field NMR spectrometers. Recently, 28.2 T (i.e., 1.2 GHz for 1H) magnets have become commercially available, and with recent advances in magnet technology, such as liquid helium recycling and magnetic field shielding [91], NMR has begun to offer far better resolution and higher sensitivity while reducing the substantial costs of maintaining the instruments compared to past decades. Other steps have been taken to enhance the sensitivity of NMR including: the development of cryoprobes increasing the signal to noise ratio 3 to 4 times, and micro-coil probes that not only increased sensitivity but also reduced the amount of sample required for the measurements [445]."}

{"project":"LitCovid-PubTator","denotations":[{"id":"1145","span":{"begin":241,"end":245},"obj":"Gene"},{"id":"1146","span":{"begin":307,"end":309},"obj":"Chemical"},{"id":"1147","span":{"begin":417,"end":423},"obj":"Chemical"}],"attributes":[{"id":"A1145","pred":"tao:has_database_id","subj":"1145","obj":"Gene:104137"},{"id":"A1147","pred":"tao:has_database_id","subj":"1147","obj":"MESH:D006371"}],"namespaces":[{"prefix":"Tax","uri":"https://www.ncbi.nlm.nih.gov/taxonomy/"},{"prefix":"MESH","uri":"https://id.nlm.nih.gov/mesh/"},{"prefix":"Gene","uri":"https://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"CVCL","uri":"https://web.expasy.org/cellosaurus/CVCL_"}],"text":"While always important in drug design, sensitivity and resolution of NMR are two major factors that need special consideration. Since both factors improve with increasing magnetic field strength, we have seen a spike in the demand for ultra-high-field NMR spectrometers. Recently, 28.2 T (i.e., 1.2 GHz for 1H) magnets have become commercially available, and with recent advances in magnet technology, such as liquid helium recycling and magnetic field shielding [91], NMR has begun to offer far better resolution and higher sensitivity while reducing the substantial costs of maintaining the instruments compared to past decades. Other steps have been taken to enhance the sensitivity of NMR including: the development of cryoprobes increasing the signal to noise ratio 3 to 4 times, and micro-coil probes that not only increased sensitivity but also reduced the amount of sample required for the measurements [445]."}

{"project":"LitCovid-sentences","denotations":[{"id":"T733","span":{"begin":0,"end":127},"obj":"Sentence"},{"id":"T734","span":{"begin":128,"end":270},"obj":"Sentence"},{"id":"T735","span":{"begin":271,"end":630},"obj":"Sentence"},{"id":"T736","span":{"begin":631,"end":917},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"While always important in drug design, sensitivity and resolution of NMR are two major factors that need special consideration. Since both factors improve with increasing magnetic field strength, we have seen a spike in the demand for ultra-high-field NMR spectrometers. Recently, 28.2 T (i.e., 1.2 GHz for 1H) magnets have become commercially available, and with recent advances in magnet technology, such as liquid helium recycling and magnetic field shielding [91], NMR has begun to offer far better resolution and higher sensitivity while reducing the substantial costs of maintaining the instruments compared to past decades. Other steps have been taken to enhance the sensitivity of NMR including: the development of cryoprobes increasing the signal to noise ratio 3 to 4 times, and micro-coil probes that not only increased sensitivity but also reduced the amount of sample required for the measurements [445]."}