PMC:7594251 / 102107-103373 JSONTXT

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LitCovid-PD-FMA-UBERON

Id Subject Object Predicate Lexical cue fma_id
T15 89-96 Body_part denotes Protein http://purl.org/sig/ont/fma/fma67257
T16 177-195 Body_part denotes proteins complexes http://purl.org/sig/ont/fma/fma67906
T17 238-245 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T18 328-335 Body_part denotes protein http://purl.org/sig/ont/fma/fma67257
T19 616-622 Body_part denotes serine http://purl.org/sig/ont/fma/fma82764

LitCovid-PD-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T118 48-51 Disease denotes CSP http://purl.obolibrary.org/obo/MONDO_0005078

LitCovid-PD-CLO

Id Subject Object Predicate Lexical cue
T21 109-117 http://www.ebi.ac.uk/efo/EFO_0000876 denotes Extremes
T22 177-195 http://purl.obolibrary.org/obo/GO_0043234 denotes proteins complexes
T23 326-327 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T24 376-377 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T25 421-422 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T26 472-473 http://purl.obolibrary.org/obo/CLO_0001020 denotes a
T27 557-563 http://purl.obolibrary.org/obo/UBERON_0000473 denotes tested
T28 1040-1043 http://purl.obolibrary.org/obo/CLO_0001195 denotes 219

LitCovid-PD-CHEBI

Id Subject Object Predicate Lexical cue chebi_id
T79552 89-96 Chemical denotes Protein http://purl.obolibrary.org/obo/CHEBI_16541
T41635 177-185 Chemical denotes proteins http://purl.obolibrary.org/obo/CHEBI_36080
T4092 238-245 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T35786 328-335 Chemical denotes protein http://purl.obolibrary.org/obo/CHEBI_36080
T89568 616-622 Chemical denotes serine http://purl.obolibrary.org/obo/CHEBI_17822
T81502 652-661 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T93491 662-684 Chemical denotes chymotrypsin inhibitor http://purl.obolibrary.org/obo/CHEBI_64943
T66488 675-684 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222
T88221 745-767 Chemical denotes chymotrypsin inhibitor http://purl.obolibrary.org/obo/CHEBI_64943
T34199 758-767 Chemical denotes inhibitor http://purl.obolibrary.org/obo/CHEBI_35222

LitCovid-PubTator

Id Subject Object Predicate Lexical cue tao:has_database_id
1111 616-622 Chemical denotes serine MESH:D012694

LitCovid-sentences

Id Subject Object Predicate Lexical cue
T674 0-6 Sentence denotes 3.6.9.
T675 7-14 Sentence denotes SAMPLEX
T676 15-196 Sentence denotes Another program that can utilize CSP called Smoothed Automatic Mapping of Protein from Listed Extremes (SAMPLEX) can help to determine the interaction surface of proteins complexes.
T677 197-354 Sentence denotes SAMPLEX takes the chemical shifts of the protein of interests in both the free and bound state and corresponding 3D structure of a protein in the free state.
T678 355-538 Sentence denotes The programs returns a confidence value for each residue to be in a perturbed or unperturbed state (0.05 as being in a perturbed state, −0.05 as remaining in their unperturbed state).
T679 539-687 Sentence denotes This approach was tested on five examples, one of which was Subtilisin BPN’ (serine protease) complexed with its inhibitor–chymotrypsin inhibitor 2.
T680 688-826 Sentence denotes The results showed that residue 2, and residues 56–62 of chymotrypsin inhibitor-2 were perturbed and residue 63 was in an ambiguous state.
T681 827-933 Sentence denotes To compare, the X-ray crystallography data showed residues 50 and 54–61 to be involved in the interaction.
T682 934-1110 Sentence denotes For subtilisin BPN’ the program predicted residues 33, 97, 99–109, 126-128, 141, 154–156, 167–171 and 218–219 to perturbed and residues 65, 98 and 220 to be in ambiguous state.
T683 1111-1266 Sentence denotes That information was also confronted with the X-ray crystallography data which shown residues 99–104, 125–128, 154–157, 167, 218–221 to be perturbed [408].